Pharmaceutical composition for treating femoral head necrosis and preparation method thereof

A technology for femoral head necrosis and composition, which is applied in the field of pharmaceutical compositions for treating femoral head necrosis and its preparation, can solve the problems of collapse and deformation of the femoral head, strong unpredictability, influence on quality of life, etc. Good therapeutic effect, good taste effect

Active Publication Date: 2013-08-28
BEIJING ZHENDONG GUANGMING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without effective intervention, 80% of patients will experience progressive aggravation within 1 to 4 years. Normal weight bearing can cause the femoral head to collapse and deform, causing joint pain and dysfunction, seriously affecting the quality of life, and eventually losing the workforce.
Most of the patients had to be treated with artificial joint replacement surgery due to the collapse of the femora

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of embodiment 1 granule

[0054] The bulk drug of the pharmaceutical composition described in the present embodiment consists of:

[0055] Sanqi 150g, Epimedium 500g, Safflower 150g, Salvia miltiorrhiza 600g, Drynaria fortunei 500g, Dipsacus 500g, Corydalis 300g, Achyranthes bidentata 300g.

[0056] In the pharmaceutical composition bulk drug of the present invention listed above, add conventional adjuvant, according to conventional fluidized bed granulation process, make granule, specifically include:

[0057] (1) Take Panax notoginseng, Epimedium, Salvia miltiorrhiza, Dipsacus and Corydalis Corydalis according to the weight selected above and mix them, add 10 times the amount of 70% ethanol, reflux extraction twice, each time for 2 hours, filter and combine Each filtrate is concentrated under reduced pressure below 60°C until it has no alcohol smell, and the alcohol extract is obtained, which is set aside;

[0058] (2) According to the above-mentione...

Embodiment 2

[0061] The preparation of embodiment 2 granules

[0062] The bulk drug of the pharmaceutical composition described in the present embodiment consists of:

[0063] Sanqi 100g, Epimedium 650g, Safflower 300g, Salvia 1400g, Drynaria 900g, Dipsacus 300g, Corydalis 600g, Achyranthes bidentata 100g.

[0064] In the pharmaceutical composition bulk drug of the present invention listed above, add conventional adjuvant, according to conventional wet granulation process, make granule, specifically include:

[0065] (1) Take Panax notoginseng, Epimedium, Salvia miltiorrhiza, Dipsacus and Corydalis Corydalis according to the weight selected above, mix them, add 10 times the amount of 80% ethanol, reflux extraction twice, each time for 1.5 hours, filter and combine Each filtrate is concentrated under reduced pressure below 60°C until it has no alcohol smell, and the alcohol extract is obtained, which is set aside;

[0066] (2) According to the weight selected above, take safflower, Drynar...

Embodiment 3

[0069] Embodiment 3 granule preparation

[0070] The bulk drug of the pharmaceutical composition described in the present embodiment consists of:

[0071] Sanqi 100g, Epimedium 750g, Safflower 100g, Salvia 1000g, Drynaria 400g, Dipsacus 800g, Corydalis 100g, Achyranthes bidentata 550g.

[0072] In the pharmaceutical composition bulk drug of the present invention listed above, add conventional adjuvant, according to conventional process, make granule, specifically include:

[0073] (1) Take Panax notoginseng, Epimedium, Salvia miltiorrhiza, Dipsacus and Corydalis Corydalis according to the weight selected above, mix them, add 6 times the amount of 90% ethanol, reflux extraction once, each time for 2 hours, filter and combine Each filtrate is concentrated under reduced pressure below 60°C until it has no alcohol smell, and the alcohol extract is obtained, which is set aside;

[0074] (2) Take safflower, drynaria rhizome and Achyranthes bidentata three raw materials according t...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating femoral head necrosis and a preparation method thereof. The pharmaceutical composition disclosed by the invention comprises the following components in parts by weight: 1-5 parts of pseudo-ginseng, 5-20 parts of herba epimedii, 1-10 parts of carthamus tinctorius, 5-30 parts of the root of red-rooted salvia, 5-20 parts of drynaria rhizome, 5-20 parts of teasel root, 1-15 parts of corydalis tuber, and 1-15 parts of the root of bidentate achyranthes. The traditional Chinese medicine granules disclosed by the invention have the characteristics of definite curative effect, stable quality and the like, is convenient to carry and take, have the functions of invigorating the circulation of blood, dispersing blood stasis, tonifying kidneys and reinforcing bones, and are used for treating gore blockage, deficiency of kidneys and bone erosion; symptoms include pain of hip bone, especially at night, inhibited bending and stretching, and soreness and weakness of waist and knees; and the above symptoms appear in the early stage and the middle stage of femoral head necrosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation process thereof, in particular to a pharmaceutical composition for treating femoral head necrosis and a preparation process thereof. Background technique [0002] Femoral head necrosis is due to the interruption or damage of the blood supply of the femoral head blood vessels, resulting in the death of bone cells and bone marrow components and later repair, which further leads to structural changes in the femoral head and collapse of bone tissue, which in turn leads to bone destruction of the femoral head and hip joint damage. Peripheral pain, joint function decline or loss and other symptoms, is a common refractory disease. In recent years, due to the abuse of hormone drugs, drinking, trauma and other reasons, the incidence rate has been increasing year by year. [0003] Necrosis of the femoral head is a worldwide refractory disease. It occurs frequently in young and middle-aged p...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P19/08
Inventor 秦文杰李明花李琳王引珍王学智白水朋岳文明姚梅芬
Owner BEIJING ZHENDONG GUANGMING PHARMA RES INST
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