Photochemical reaction synthesis for isoflavones

A technology of isoflavones and bromoisoflavones, applied in the field of heterocyclic compounds, can solve the problems of complex operation, complex reaction process, and use, and achieve the effects of mild reaction conditions, low production cost, and simple process
CN103265518AInactive Publication Date: 2013-08-28SHAANXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Publication Date
2013-08-28
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention belongs to the technical field of heterocyclic compounds, and particularly relates to a heterocyclic compound with an unhydrogenated heterocycle, a six-membered cycle, and an oxygen atom used as the only heterocyclic atom for being fused with other cycles. The invention provides a novel method for photochemical reaction synthesis for isoflavones. The process of the novel method comprises the following steps of: adding (substituted) 3-(dimethylamino)-1-(2-hydroxylphenyl) propyl-2-alkene-1-ketone, substituted aromatic hydrocarbon and iodine elementary substance in a solvent; reacting under ultraviolet irradiation; performing reduced pressure distillation to recover the solvent after the reaction; and obtaining the compounds disclosed by the invention, namely, isoflavone pure products, via column chromatography separation and purification. The medicinal isoflavones of ipriflavone, formononetin, isoflavoues aglycone, genistein, puerarin and the like are prepared by applying the method, a new technical route is provided for industrialized production for the medicines aforementioned, and a series of novel isoflavone compounds with potential physiological activity are prepared simultaneously.
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Description

technical field

[0001] The invention belongs to the technical field of heterocyclic compounds, and specifically relates to a heterocyclic compound containing a six-membered ring without hydrogenation, which has an oxygen atom as the only ring heteroatom and is fused with other rings. Background technique

[0002] Isoflavones are phenolic compounds based on benzochromone rings formed by cyclization of cinnamoyl-CoA side chains during the metabolism of phenylalanine in plants. The 3-phenyl derivatives are isoflavones, which belong to plants secondary metabolites. Modern pharmacological studies have shown that isoflavones play a role in the cardiovascular system, endocrine system, central nervous system, immune system and anti-tumor, anti-oxidation and free radical scavenging effects, estrogen-like effects, anti-inflammatory and anti-allergic effects, antibacterial and antiviral effects etc. have obvious pharmacological effects. For example, formononetin that can prevent and ...

Claims

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