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Space-induced efficient bifidobacterium bifidum and application thereof as well as preparation method of capsule preparation of space-induced efficient bifidobacterium bifidum

A bifidobacterium bifidum and space mutagenesis technology, applied in the field of microorganisms, can solve the problems of storage and oral inactivation, difficulties in the production of live bacterial preparations, unstable mutant strains of bifidobacteria, etc., to achieve the treatment of indigestion, Effects of regulating the balance of intestinal flora and improving acid and salt tolerance

Active Publication Date: 2013-08-28
神舟太空产品高科技成果推广中心集团有限公司
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Problems solved by technology

Although "replenishment of live bacteria in vitro" avoids the unsafe problems brought about by the method of "proliferation of live bacteria in vivo", bifidobacteria are a strict anaerobic bacteria, and the production of live bacteria preparations is difficult, and due to the impact of live bacteria on Sensitive to acids, bases, and heat, making preservation and oral inactivation prone
At the same time, the mutant strains of bifidobacterium induced by conventional mutagenesis are unstable, which causes greater difficulties in the production of live bacterial preparations

Method used

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  • Space-induced efficient bifidobacterium bifidum and application thereof as well as preparation method of capsule preparation of space-induced efficient bifidobacterium bifidum
  • Space-induced efficient bifidobacterium bifidum and application thereof as well as preparation method of capsule preparation of space-induced efficient bifidobacterium bifidum
  • Space-induced efficient bifidobacterium bifidum and application thereof as well as preparation method of capsule preparation of space-induced efficient bifidobacterium bifidum

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Embodiment Construction

[0067] The present invention will be described in detail below in combination with specific embodiments.

[0068] A high-efficiency space mutagenesis Bifidobacterium bifidum (Bifidobacterium bifidum) S7-T5 described in the present invention was preserved on May 19, 2011 in the General Microbiology Center of China Microbiological Culture Collection Management Committee, the address is Beichen, Chaoyang District, Beijing No. 3, No. 1 Yard, West Road, Institute of Microbiology, Chinese Academy of Sciences, the deposit number is CGMCC No. 4886.

[0069] 1. Mutagenesis of Bifidobacterium bifidum:

[0070] Bifidobacterium bifidum with the preservation number CGMCC 1.2212 was used as the starting strain, and the number was S7-D5, which was divided into 2 parts, 1 part was stored at 4°C as a ground control strain, and 1 part was used as a carrying strain to carry the Shenzhou VII manned spacecraft Perform steric mutagenesis.

[0071] Second, the preparation and cultivation of bacter...

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Abstract

The invention relates to a space-induced efficient bifidobacterium bifidum and application thereof as well as a preparation method of a capsule preparation of the space-induced efficient bifidobacterium bifidum. Bifidobacterium bifidum is strict anaerobic bacteria; the active microbial agents of the bifidobacterium bifidum are difficultly produced; and the viable organism is sensitive to acid, alkali and heat, so that inactivation is easily caused by storage and oral administration. The invention provides a bifidobacterium bifidum (Bifidobacterium bifidum) S7-T5 which can be applied to preparation of a medicine and a health-care product for adjusting balance of intestinal flora. The oxygen-resistant characteristics, the acid-resistant characteristics and the salt-tolerant characteristics of the bifidobacterium bifidum disclosed by the invention are obviously improved; and the bifidobacterium bifidum has stable hereditary and industrial characteristics. A living bacterium capsule preparation produced by the strain S7-T5 disclosed by the invention can improve digestion, adjust intestinal flora balance, treat diarrhea and dyspepsia by clinical verification, can be applied to bifidobacterium bifidum health-care products and bifidobacterium bifidum medicine, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a strain of Bifidobacterium bifidum with high efficiency of space mutagenesis, its application and a preparation method of a capsule preparation. Background technique [0002] Bifidobacterium bifidum, Latin scientific name Bifidobacterium bifidum , a type species of the genus Bifidobacterium. Bifidobacterium Orla-Jensen is an anaerobic Gram-positive bacillus isolated from the feces of breast-fed infants by French scholar Tissier in 1899. The ends are often forked, hence the name Bifidobacterium. Bifidobacterium is a physiological bacterium in the human gastrointestinal tract. It is a beneficial bacterium. It is inseparable from the health of the human body. The most common distribution is in breast-fed infants. Bifidobacterium not only has many benefits for infants and young children, such as nutrition, immunity and anti-infection, but also has anti-allergy, anti-tumor, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A23L1/29A61K35/74A61K9/48A61P1/00C12R1/01A23L33/00A61K35/745
Inventor 赵恒
Owner 神舟太空产品高科技成果推广中心集团有限公司
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