Space-induced efficient bifidobacterium bifidum and application thereof as well as preparation method of capsule preparation of space-induced efficient bifidobacterium bifidum

Abstract

The invention relates to a space-induced efficient bifidobacterium bifidum and application thereof as well as a preparation method of a capsule preparation of the space-induced efficient bifidobacterium bifidum. Bifidobacterium bifidum is strict anaerobic bacteria; the active microbial agents of the bifidobacterium bifidum are difficultly produced; and the viable organism is sensitive to acid, alkali and heat, so that inactivation is easily caused by storage and oral administration. The invention provides a bifidobacterium bifidum (Bifidobacterium bifidum) S7-T5 which can be applied to preparation of a medicine and a health-care product for adjusting balance of intestinal flora. The oxygen-resistant characteristics, the acid-resistant characteristics and the salt-tolerant characteristics of the bifidobacterium bifidum disclosed by the invention are obviously improved; and the bifidobacterium bifidum has stable hereditary and industrial characteristics. A living bacterium capsule preparation produced by the strain S7-T5 disclosed by the invention can improve digestion, adjust intestinal flora balance, treat diarrhea and dyspepsia by clinical verification, can be applied to bifidobacterium bifidum health-care products and bifidobacterium bifidum medicine, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to a strain of Bifidobacterium bifidum with high efficiency of space mutagenesis, its application and a preparation method of a capsule preparation. Background technique [0002] Bifidobacterium bifidum, Latin scientific name Bifidobacterium bifidum , a type species of the genus Bifidobacterium. Bifidobacterium Orla-Jensen is an anaerobic Gram-positive bacillus isolated from the feces of breast-fed infants by French scholar Tissier in 1899. The ends are often forked, hence the name Bifidobacterium. Bifidobacterium is a physiological bacterium in the human gastrointestinal tract. It is a beneficial bacterium. It is inseparable from the health of the human body. The most common distribution is in breast-fed infants. Bifidobacterium not only has many benefits for infants and young children, such as nutrition, immunity and anti-infection, but also has anti-allergy, anti-tumor, ...

AI Technical Summary

Problems solved by technology

Although "replenishment of live bacteria in vitro" avoids the unsafe problems brought about by the method of "proliferation of live bacteria in vivo", bifidobacteria are a strict anaerobic bacteria, and the production of live bacteria preparations is difficult, and due to the impact of live bacteria on Sensitive to acids, bases, and heat, making preservation and oral inactivation prone

At the same time, the mutant strains of bifidobacterium induced by conventional mutagenesis are unstable, which causes greater difficulties in the production of live bacterial preparations

Images