Hydrothermal preparation method of nano-titania coating on surface of magnesium alloy intravascular stent

A nano-titanium oxide, magnesium alloy blood vessel technology, applied in metal material coating process, coating and other directions, can solve the problem that titanium oxide coating does not have specific surface area and porosity, magnetron sputtering equipment is complex and expensive, and it is difficult to achieve load-bearing. drug function and other issues, to achieve the effects of good blood compatibility, strong binding force, and excellent corrosion resistance

Active Publication Date: 2013-10-02
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, electroless plating is a method of using a strong reducing agent in a solution containing metal ions to reduce metal ions to metal and deposit them on the surface of the material to form a dense coating. However, considering the toxic effect of Ni element on the human body, this coating is not suitable. Applied to biological materials; coatings prepared by micro-arc fluorination generally have more defects and poor compactness; magnetron sputtering equipment is more complicated and expensive, and amorphous titanium dioxide is generally obtained under low temperature conditions, which requires heat treatment Transform it into anatase or rutile phase with good hemocompatibility
In addition, the titanium oxide coatings prepared by the above methods do not have high specific surface area and porosity, and it is difficult to realize the drug loading function.

Method used

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  • Hydrothermal preparation method of nano-titania coating on surface of magnesium alloy intravascular stent
  • Hydrothermal preparation method of nano-titania coating on surface of magnesium alloy intravascular stent
  • Hydrothermal preparation method of nano-titania coating on surface of magnesium alloy intravascular stent

Examples

Experimental program
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Effect test

Embodiment 1

[0021] On the surface of the electropolished Mg-Zn-based alloy vascular stent, a nano-flaky titanium oxide coating is prepared, and the preparation steps are as follows:

[0022] (1) Drop hydrofluoric acid into absolute ethanol, stir until mixed evenly, then add tetrabutyl titanate, stir until mixed evenly to form solution A, and the molar concentration of hydrofluoric acid in solution A is 0.2mol· L -1 , the molar concentration of tetrabutyl titanate in solution A is 0.1mol L -1 ;

[0023] (2) Stir and mix ammonium fluoride and deionized water evenly to form solution B, the molar concentration of ammonium fluoride in solution B is 0.2mol L -1 , mix and stir solution A and solution B evenly to form solution C, the volume ratio of solution A and solution B is 60:1, and the molar concentration of ammonium fluoride in solution C is 3.3mmol L -1 ;

[0024] (3) Put the electropolished magnesium alloy stent into solution C, and react with it under the condition of 170°C for 10 h...

Embodiment 2

[0029] On the surface of the electropolished Mg-Zn-based alloy vascular stent, a nano-flaky titanium oxide coating is prepared, and the preparation steps are as follows:

[0030] (1) Drop hydrofluoric acid into absolute ethanol, stir until mixed evenly, then add tetrabutyl titanate, stir until mixed evenly to form solution A, and the molar concentration of hydrofluoric acid in solution A is 0.1mol· L -1 , the molar concentration of tetrabutyl titanate in solution A is 0.2mol L -1 ;

[0031] (2) Stir and mix sodium fluoride and deionized water evenly to form solution B. The molar concentration of sodium fluoride in solution B is 0.1mol L -1 , mix and stir solution A and solution B evenly to form solution C, the volume ratio of solution A and solution B is 30:1, and the molar concentration of sodium fluoride in solution C is 3.3mmol L -1 ;

[0032] (3) Put the electropolished magnesium alloy stent into the solution C, and react it with water heat at 100°C for 24 hours; take ...

Embodiment 3

[0034] Prepare a nano-sheet titanium oxide coating on the surface of the electropolished Mg-Re-based alloy vascular stent, and the preparation steps are as follows:

[0035] (1) Drop hydrofluoric acid into absolute ethanol, stir until it is evenly mixed, then add tetrabutyl titanate, and stir until it is evenly mixed to form solution A. The molar concentration of hydrofluoric acid in solution A is 0.4mol· L -1 , the molar concentration of tetrabutyl titanate in solution A is 0.3mol L -1 ;

[0036] (2) Stir and mix potassium fluoride and deionized water evenly to form solution B. The molar concentration of potassium fluoride in solution B is 0.4mol L -1 , mix and stir solution A and solution B evenly to form solution C, the volume ratio of solution A and solution B is 150:1, and the molar concentration of potassium fluoride in solution C is 2.6mmol L -1 ;

[0037] (3) Put the electrolytically polished magnesium alloy stent into solution C, and react it with water heat at 20...

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Abstract

The invention discloses a hydrothermal preparation method of a nano-titania coating on surface of a magnesium alloy intravascular stent. The preparation method comprises the following steps: uniformly mixing absolute ethyl alcohol and hydrofluoric acid, and then adding tetrabutyl titanate for blending to obtain solution A, wherein the concentration of hydrofluoric acid in the solution A is 0.1-0.4 mol/L, and the concentration of tetrabutyl titanate is 0.1-0.3 mol/L; dissolving fluoride salt in deionized water to obtain solution B, wherein the concentration of fluoride salt in the solution B is 0.1-0.4 mol/L; then uniformly mixing the solution A and the solution B to obtain solution C; placing the magnesium alloy intravascular stent after processing into the solution C, and taking out after a hydrothermal reaction so as to obtain the nano-titania coating. The method has the advantages of being environment-friendly, convenient to process, easily-obtained, low in price, and the like; the bonding force of the obtained sheet nano-titania coating and the magnesium alloy intravascular stent is high, and the nano-titania coating has good corrosion resistance and blood compatibility, the coating is large in porosity and specific area, the dimensions are uniform and controllable, and the nano-titania coating is suitable for intravascular stent medicine carrying.

Description

technical field [0001] The invention belongs to the technical field of surface coating coating, and in particular relates to a hydrothermal preparation method of a nano-titanium oxide coating on the surface of a magnesium alloy vascular stent. Background technique [0002] Magnesium and magnesium alloys have good mechanical properties, biocompatibility and degradability, and have become a research hotspot in degradable vascular stent materials in recent years. However, the corrosion resistance of magnesium and its alloys is poor, especially in Cl - A faster corrosion rate exists in the physiological environment, therefore, its degradation rate in the in vivo environment must be rationally controlled so that it maintains its mechanical integrity for a specific period of time and its biocompatibility is improved by surface treatment. [0003] Titanium oxide can effectively prevent the charge transfer between biological factors and materials in the body, reduce the adsorption ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C26/00
Inventor 关绍康侯树森王利国朱世杰任晨星
Owner ZHENGZHOU UNIV
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