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In-situ gel for enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and in situ gel, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve adverse disease outcomes, affect drug efficacy, and offset efficacy and other problems, to achieve the effect of good drug effect, reducing the number of doses, and slow drug release

Inactive Publication Date: 2013-11-13
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the impact of animal illness on appetite and drinking desire, and the unpleasant taste of most drug powders or their aqueous solutions, the administration of drinking water or condiments (orally) is restricted; the administration of ordinary injections requires multiple repetitions of a course of treatment, and frequent injections of Baoding animals are time-consuming. It is troublesome, and it is easy to cause animal stress, which can offset the curative effect or even aggravate the disease, affect the efficacy of the drug, and is not conducive to the outcome of the disease

Method used

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  • In-situ gel for enrofloxacin injection and preparation method thereof
  • In-situ gel for enrofloxacin injection and preparation method thereof
  • In-situ gel for enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 10% enrofloxacin in situ gel for injection

[0026]

[0027] Preparation method: Take an appropriate amount of water for injection, heat it to 50-70°C, add enrofloxacin, dissolve it with an appropriate amount of sodium hydroxide solution, add the prescribed amount of benzalkonium bromide, stir evenly, and cool; the selected gel matrix and carboxymethyl cellulose sodium on the above liquid surface, and refrigerated at about 4°C for more than 24 hours to obtain a clear, lump-free, uniformly dispersed solution, constant volume, hydrochloric acid to adjust the pH value, filtered through a microporous membrane, and stirred evenly , repackage, vested.

[0028]The prepared in situ gel was evaluated in vitro, including gelation temperature, gelation time, thermal reversibility, release rate, viscosity, pH value, etc. The measurement methods of each item are as follows, the measurement results are shown in Table 1, and the in vitro release results are shown in the accompanyi...

Embodiment 2

[0036] 10% enrofloxacin in situ gel for injection

[0037]

[0038] Preparation method: Take an appropriate amount of water for injection, heat to 50-70°C, add enrofloxacin and carbomer, (dissolve with an appropriate amount of sodium hydroxide solution, add the prescribed amount of benzyl alcohol, stir evenly, and cool; Sprinkle the gum base and povidone K-30 on the above liquid surface, and refrigerate at 4°C for more than 24 hours to obtain a clear, lump-free, and evenly dispersed solution. Constant volume, adjust the pH value with hydrochloric acid, filter through a microporous membrane, and stir Uniform, sub-packaged, vested. The in vitro performance evaluation method is the same as in Implementation 1. The results are shown in Table 1, and the in vitro release results are shown in the accompanying drawings.

Embodiment 3

[0040] 10% enrofloxacin in situ gel for injection

[0041]

[0042]

[0043] Preparation method: Take an appropriate amount of water for injection, heat it to 50-70°C, add enrofloxacin, dissolve it with an appropriate amount of sodium hydroxide solution, add the prescribed amount of benzalkonium bromide, stir evenly, and cool; the selected gel matrix And methyl cellulose, povidone K-30 sprinkled on the above liquid surface, refrigerated at 4 ℃ for more than 24h, to obtain a clear, no lump, uniformly dispersed solution, constant volume, hydrochloric acid to adjust the pH value, microporous membrane filtration After that, stir evenly, divide into packages, and get it. The in vitro performance evaluation method is the same as that in Implementation 1. The results are shown in Table 1, and the in vitro release results are shown in the accompanying drawings.

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PUM

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Abstract

The invention belongs to the field of special pharmaceutical preparations for animals, and relates to an in-situ gel preparation for enrofloxacin injection and a preparation method thereof. The preparation comprises the following components in parts by weight: 5.0-20.0 parts of enrofloxacin, 14.5-32.5 parts of P407, 0.5-10.5 parts of P188, 25.0-90.0 parts of water, 0.01-10.0 parts of a high molecular retardant, 0.01-3.0 parts of a preservative and appropriate amount of a pH adjustor. The preparation provided by the invention is a freely flowing liquid at room temperature, and forms a semi-solid gel through dosage by intramuscular injection or subcutaneous injection, so that the preparation is just delivered once in a course of treatment. The preparation has the advantages of stable property, long lasting time for delivery, exact curative effect, strong animal adaptability, no toxic and side effects and adverse reaction and the like, and is simple to prepare and convenient to delivery. The preparation provided by the invention has broad-spectrum antibacterial effect, and can be used as a medicine for preventing and treating diseases of animals such as pigs, sheep, dogs, cats and cattle.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to an in-situ gel for enrofloxacin injection with a suitable phase transition temperature and a preparation method thereof. Background technique [0002] Enrofloxacin, also known as ethyl ciprofloxacin, chemical name: 1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-7-(4-ethyl- 1-piperazinyl)-3-quinolinecarboxylic acid is a third-generation fluoroquinolones for animals. Developed by Bayer AG of Germany, it was first listed in New Zealand in 1987, and it was successfully developed and put into use in my country in 1993. [0003] Enrofloxacin inhibits and kills a wide range of pathogenic microorganisms, and has good antibacterial effects on Gram-negative bacteria, positive bacteria, mycoplasma and chlamydia. Sensitive bacteria include Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolyticus, Vi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/496A61K47/34A61P31/04
Inventor 余祖功耿智霞郭凡溪田静
Owner NANJING AGRICULTURAL UNIVERSITY
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