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Hydrogel transdermal patch for preventing congealing cold blood stasis-type primary dysmenorrheal, and preparation method of hydrogel transdermal patch

A technology for primary dysmenorrhea and transdermal patch, which is applied in the directions of non-central analgesics, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve the problem of low bioavailability and first-pass effect. Gastrointestinal tract damage and other problems, to achieve the effect of improving bioavailability, facilitating drug transdermal, and good anti-dysmenorrhea effect

Active Publication Date: 2013-12-04
南京百草和康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the traditional Chinese medicines currently used to treat dysmenorrhea are mainly taken orally, and there are problems such as first-pass effect, damage to the gastrointestinal tract, and low bioavailability.

Method used

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  • Hydrogel transdermal patch for preventing congealing cold blood stasis-type primary dysmenorrheal, and preparation method of hydrogel transdermal patch
  • Hydrogel transdermal patch for preventing congealing cold blood stasis-type primary dysmenorrheal, and preparation method of hydrogel transdermal patch
  • Hydrogel transdermal patch for preventing congealing cold blood stasis-type primary dysmenorrheal, and preparation method of hydrogel transdermal patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A transdermal patch with anti-cold blood stasis type primary dysmenorrhea effect, comprising a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which comprises the following steps:

[0034] (1) Take 900g of angelica, 300g of Chuanxiong, 600g of red peony, 300g of cinnamon, 150g of cumin, 600g of Wulingzhi, 300g of myrrh, 900g of Puhuang, 300g of Corydalis, 300g of dried ginger, add 8 times the amount of water and soak for 12 hours, After decocting for 2 hours, pour out the decoction, continue to add 8 times the amount of water to decoct for 2 hours, collect the volatile oil parts with a volatile oil extractor during decoction, combine the two decoctions, and concentrate under reduced pressure at 50°C to obtain a concentration of 1 g Crude drug / ml concentrated solution 4600 ml, then add 95% ethanol to make the concentration of ethanol in the concentrated solution reach 80%, let it stand for 24 hours, take the supernatant ...

Embodiment 2

[0038] A transdermal patch with anti-cold blood stasis type primary dysmenorrhea effect, comprising a backing layer, a drug-containing matrix layer and an anti-adhesive layer, the preparation method of which comprises the following steps:

[0039] (1) Take 450g of angelica, 140g of Chuanxiong, 300g of red peony, 150g of cinnamon, 75g of cumin, 300g of Wulingzhi, 150g of myrrh, 450g of Puhuang, 150g of Corydalis, 150g of dried ginger, add 6 times the amount of water and soak for 10 hours, After decocting for 2 hours, pour out the decoction, continue to add 6 times the amount of water to decoct for 2 hours, use a volatile oil extractor to collect the volatile oil during decoction, combine two decoctions, and concentrate under reduced pressure at 50°C to obtain a concentration of 1 g 2300 ml of concentrated solution of crude drug / ml, then add ethanol with a concentration of 95% to make the concentration of ethanol in the concentrated solution reach 70%, let it stand for 24 hours, ...

Embodiment 3

[0042] Example 3 Blood circulation promoting and blood stasis removing test

[0043] 1 Experimental materials

[0044] 1.1 Experimental Animals SD female rats used in the experiment, weighing 200g±10g, were provided by the Experimental Animal Center (SPF level) of Nanjing Medical University (license number SCXK (Su) 2002-0031).

[0045] 1.2 Reagent Epinephrine hydrochloride solution, produced by Southwest Pharmaceutical Co., Ltd., batch number: 071101; sodium citrate, produced by Tianjin Biochemical Pharmaceutical Factory, batch number: 20071107

[0046] 1.3 Instrument LG-R-80 computerized blood viscosity tester, product of Beijing Shidi Scientific Instrument Company.

[0047] 2 Experimental methods

[0048] 2.1 Model preparation The normal group was fed routinely, and the rats in the model group and treatment group (attached with the patch prepared in Example 1 of the present invention) were placed in ice water at 0°C to 1°C for 5 minutes, once a day for seven consecutive d...

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Abstract

The invention discloses an external preparation (hydrogel transdermal patch) for preventing congealing cold blood stasis-type primary dysmenorrheal, and a preparation method of the hydrogel transdermal patch. The hydrogel transdermal patch comprises a back lining layer, a medicated substrate layer fixed on the back lining layer, and an anti-sticking layer covering the medicated substrate layer, wherein the medicated substrate layer comprises the following materials by weight: 20 to 60 parts of hydrogel substrate, 10 to 50 parts of volatile oil part, 20 to 70 parts of elution part, and 10 to 30 parts of transdermal penetration enhancer. The transdermal patch has the advantages that the active components are clean; the composition is scientific and reasonable; the drug loading capacity is relatively large; experiments show that the hydrogel transdermal patch is excellent anti-dysmenorrheal, anti-inflammatory and blood circulation activating activities, has a long-acting controlled release effect of slowly releasing medicine active ingredients for a long time, and is convenient to use, comfortable, and non-irritant and non-allergy to skin.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition and an external hydrogel patch, in particular to a traditional Chinese medicine composition transdermal patch capable of preventing and treating primary dysmenorrhea of ​​cold coagulation and blood stasis type and a preparation method thereof. Background technique [0002] Primary dysmenorrhea (PD) is the most common disease of female endocrine disorders. Its incidence rate is high, the lowest incidence rate is 33.19%, and the incidence rate in foreign countries is higher, with severe cases accounting for 15%. It affects the work and life quality of young women . Traditional medicine believes that the onset of dysmenorrhea is mainly caused by emotional injury, careless daily life or the harm of six evils, and is related to the fertile body, menstrual period, and the special physiological environment before and after menstruation. Its pathogenesis is mainly due to Chong Ren stasis or ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/70A61K47/38A61P15/00A61P29/00A61K35/24
Inventor 宿树兰段金廒钱大玮刘培成俊
Owner 南京百草和康医药科技有限公司
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