Method for reducing amide compounds

A technology of amine compounds and reduction of amides, which is applied in the preparation of organic compounds, preparation of amino compounds, chemical instruments and methods, etc., can solve the problems of post-processing troubles, high reaction costs, C-N bond breakage, etc. The effect of simple operation and mild reaction conditions
CN103435430BInactive Publication Date: 2015-02-18SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2015-02-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for reducing amide compounds, which reduces various amides through low valent tiron. Low valent tiron prepared by reducing titanium tetrachloride through magnesium powder is reacted with amide in tetrahydrofuran at 0 DEG C or normal temperature so as to obtain corresponding amine. The method has the advantages that the reaction condition is mild, reagent adopted is chip and easy to get, the method is convenient to operate, substrate has a wide applicable scope, functional group has good compatibility, the reaction is rapid, and the yield is high.
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Description

technical field

[0001] The invention relates to a new method for reducing amides. In the method, low-valent titanium reagent is used as a reducing agent to reduce various types of amides to obtain corresponding amine compounds. Background technique

[0002] Amide reduction is one of the important organic reactions, widely used in chemistry, biology, materials and other fields. The partial amide reduction method is widely used, but there are still many shortcomings.

[0003] The reduction of amides by catalytic hydrogenation is an earlier and more ideal and economical method. However, the reaction conditions are harsh, and the reaction is generally carried out at high temperature and high pressure (Angew. Chem. Int. Ed. 52 (2013) 2231-2234). Transition metal-catalyzed organosilicon reduction, high reaction temperature, mainly suitable for tertiary amides (J. Am. Chem. Soc. 132 (2010) 1770-1771), partly suitable for secondary amides (J. Am. Chem. Soc . 134 (2012) 11304–1130...

Claims

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