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Paper chip and preparation method thereof

A technology of paper chip and filter paper, applied in the field of paper chip and its preparation, can solve the problems of high toxicity of SU-8 photosensitive adhesive, which limits the development and application of paper chip

Active Publication Date: 2013-12-11
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the high toxicity of the SU-8 photosensitive adhesive used, the further development and application of paper chips in the paper-based sensing analysis platform (μpad) is greatly limited.

Method used

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  • Paper chip and preparation method thereof
  • Paper chip and preparation method thereof
  • Paper chip and preparation method thereof

Examples

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Effect test

preparation example Construction

[0028] The invention provides a method for preparing a paper chip, comprising the following steps:

[0029] A) Soak the filter paper in the pre-polymerization solution, the pre-polymerization solution is a mixture of prepolymer and photoinitiator, the prepolymer contains acrylic acid functional group or methacrylic acid functional group, and the photoinitiator is Photoinitiators that can generate phenylcarbonyl radicals when excited by light;

[0030] B) Cover the surface of the infiltrated filter paper with a photolithography mask with a preset pattern, and then expose it to ultraviolet light;

[0031] C) Cleaning the exposed filter paper sheet with methanol to obtain a paper chip.

[0032] The invention applies photocatalytic free radical polymerization to the preparation of paper chips, replaces the traditional method of using SU-8 photosensitive adhesive to prepare paper chips, and establishes a novel and environment-friendly method for preparing paper chips.

[0033] f...

Embodiment 1

[0064] Using a filter paper sheet from Whatman chromatography paper, model number 3030-961, and a thickness of 0.34 mm, the filter paper sheet is soaked in a pre-polymerization liquid, and the pre-polymerization liquid is composed of polyethylene glycol diacrylate and 2-hydroxyl -2-Methyl-1-propyl-1-propanone is prepared by mixing at a volume ratio of 10:1.

[0065] Cover the surface of the wetted filter paper with a photolithographic mask with a dendritic pattern, and at the same time place a black paper under the filter paper, then place it under ultraviolet light for exposure, and the wavelength of the ultraviolet light is 365nm. The intensity of ultraviolet light is 15mJ / cm 2 , the exposure time is 3s.

[0066] Immerse the exposed filter paper in the methanol solution for 20 minutes, remove the unexposed pre-polymerization liquid, and obtain the following image 3 The paper chip A shown, image 3 Optical photograph of paper chip A prepared for Example 1 of the present i...

Embodiment 2

[0069] Adopt from Dongyang Industrial&Trading Co.,Ltd, model is 102, the filter paper sheet that thickness is 0.14mm, carries out the preparation of paper chip according to the step of embodiment 1, obtains as follows Figure 5 Paper chip B shown, Figure 5 Optical photograph of paper chip B prepared for Example 2 of the present invention. From Figure 5 As can be seen in , the paper chips B have different accuracies.

[0070] It can be known from Example 1 and Example 2 that the preparation method of the paper chip provided by the present invention does not depend on the selection of the thickness of the filter paper, and is not affected by the properties of the filter paper.

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Abstract

The invention provides a paper chip and a preparation method thereof. The preparation method comprises the following steps of: soaking a piece of filter paper in a prepolymer solution, wherein the prepolymer solution is a mixture of a prepolymer and a photoinitiator, the prepolymer contains an acrylic acid functional group or a methacrylic acid functional group, and the photoinitiator is capable of generating phenyl carbonyl free radicals under optical excitation; covering a photo-etched mask with default patterns on the surface of the soaked filter paper, and then placing the filter paper under ultraviolet light for exposure; cleaning the exposed filter paper by using methanol to obtain the paper chip. In the preparation method, the light-catalyzed free radical reaction between the prepolymer and the photoinitiator, in combination with a mask photo-etching technology, is used for constructing micro-fluid passages on a paper substrate. According to the preparation method, the environment-friendly prepolymer with good biocompatibility is mixed with the photoinitiator to prepare the prepolymer solution which replaces SU-8 photosensitive adhesive with high toxicity to serve as a fixed base material, and the characteristic of high accuracy of the mask photo-etching technology is combined, so that the environment-friendly paper chip and the preparation method thereof are developed.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a paper chip and a preparation method thereof. Background technique [0002] Microfluidic chip technology integrates the basic operation units such as sample preparation, reaction, separation and detection in the process of biological, chemical and medical analysis into a micron-scale chip, and automatically completes the entire analysis process. Chip is the core content of microfluidic chip technology. The substrate materials of traditional microfluidic analysis chips include silicon materials, glass quartz and organic polymers. The processing methods include photolithography, molding and hot pressing. From the perspective of substrate materials, "paper" as the substrate of the analysis platform has the advantages of low cost, strong applicability, biodegradability and good chemical properties. It has been widely used in various analysis systems. Compared with the tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D21H17/37B01L3/00G03F7/004G03F7/027
Inventor 李敬陈朝贵张晓伟汪尔康
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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