Method for preparing beta-amino-carbonyl compound

A technology for aminocarbonyl compounds, applied in the field of preparation of β-aminocarbonyl compounds, can solve the problems of complex substrates, harsh reaction conditions, and long reaction time in the operation process, and achieve high atom economy, simple operation, and great application potential Effect
CN103467321AInactive Publication Date: 2013-12-25SHAANXI NORMAL UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Publication Date
2013-12-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for preparing a beta-amino-carbonyl compound. Aldehydes, ketones and amines are directly mixed under the condition of synergetic catalysis of titanocene dichloride and a ligand, and react at room temperature to obtain the beta-amino-carbonyl compound, wherein the ligand is salicylic acid or salicylic acid derivatives or structural analogues thereof. According to the method, the catalyst used in the method is low in cost, nontoxic and stable and effective to air and water, the reaction condition is mild, a solvent is not needed, the operation is simple, and the atom economy is high.
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Description

technical field

[0001] The present invention relates to the preparation method of β-aminocarbonyl compound. Background technique

[0002] β-Aminocarbonyl compounds are important structural units of many natural products, drugs, and synthetic intermediates. For example, 1,2-cyclopentanone bis-Mannich bases containing β-aminocarbonyl structural units have strong anti-inflammatory and anti-cancer activities. The Mannich reaction has always been the most basic and important reaction method for the construction of β-aminocarbonyl compounds. The three-component Mannich reaction has high atomic economy, simple operation, and environmental protection, and is the preferred way to prepare β-aminocarbonyl compounds. Many Bronsted acid or Lewis acid catalysts are used to catalyze the preparation of such compounds, such as sulfonic acid compounds, polymer-supported sulfonic acids, heteropolyacids, proline, FeCl 3 , InCl 3 、BiCl 3 、Bi(OTf) 3 , CeCl 3 , CAN, Yb(OPf) 3 , ZrOCl 2 , ...

Claims

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