19results about How to "Gentle operation" patented technology

The invention discloses a multi-metal borate nano-particle as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of small molecules with alkyl chains, performing high-temperature thermal decomposition on an organic metal compound or a metal salt compound precursor and organic borate in a solvent, and then centrifuging, modifying, performing ultrafiltration, dialyzing and purifying to obtain the multi-metal borate nanoparticles. The preparation method disclosed by the invention has the characteristics of mildness, high efficiency and strong controllability. The multi-metal borate nanoparticles prepared by the preparation method disclosed by the invention have the advantages of monodisperse size, relatively high magnetic property and good biocompatibility. Therefore, the prepared multi-metal borate nanoparticles not only have multi-modal imaging functions such as magnetic resonance imaging, near-infrared two-region imaging, nuclear medicine imaging and magnetic particle imaging, but also can be used for various treatment means such as magnetocaloric therapy and boron neutron capture therapy; potential advantages are realized in biomedical applications such as magnetic targeting tumor treatment and imaging contrast agents, and high practical values are realized.

The invention relates to the field of nano-composite flame retardants, in particular to a preparation method of a nano-composite flame retardant with alkali metal silsesquioxane particles loaded on the surface of a carbon nano tube, which comprises the following steps: adding an organic solvent and the carbon nano tube into a reaction container, performing ultrasonic and mechanical stirring, adding alkali metal silsesquioxane powder into the reaction container, and performing stirring to obtain a nano-composite flame retardant; a grey black mixed solution is obtained; and carrying out suction filtration on the mixed solution, and drying the obtained filter cake to prepare the nano composite flame retardant with alkali metal silsesquioxane particles loaded on the surface of the carbon nano tube. The product prepared by the invention still presents a one-dimensional nanotube shape, the structure thermal stability of the product is good, the surface of the prepared nanotube is rough on the premise of keeping the one-dimensional nanotube microstructure, agglomeration among a plurality of nanotubes is effectively prevented, and the performance of the nanotube is improved. And the flame retardant is a nano composite flame retardant with dual excellent characteristics of the carbon nano tube and the metal silsesquioxane.

The invention relates to a pharmaceutical synthesis process of Tovorafenib (Tovorafenib). According to the synthesis process and the related preparation method of the chiral alpha-miscellaneous amine, prochiral ketone is directly reduced and aminated into optical pure chiral alpha-miscellaneous amine by a one-step method under a mild condition by utilizing a biocatalyst amine dehydrogenase, the defects of the existing catalysis technology can be overcome, the process route is simple, the reaction condition is mild, the yield is high, and the method is suitable for industrial production. The method has green synthesis advantages of step economy, atom economy and the like, and has the advantages of good stereoselectivity (ee value is as high as 99%) and the like. In the synthesis route, a method of condensing amino and carboxyl in an HATU and alkaline environment is mostly adopted, the operation is simple, the reaction yield is high, and the method is suitable for batch production.

This application discloses a method for the conversion of C4-C6 alkanes. In a reactor, a raw material containing hydrogen and C4-C6 alkanes is contacted with a catalyst and reacted to obtain a product containing small molecule hydrocarbons; the C4-C6 alkanes are selected from at least one of n-butane, isobutane, n-pentane, isopentane, and 2,3-dimethylbutane; the small molecule hydrocarbons are selected from at least one of ethane, propane, n-butane, and n-pentane; the catalyst is prepared by the following steps: (1) mixing clay and sol, spray drying to obtain microspheres with a diameter of 1-50 μm; (2) immersing the microspheres in an aqueous solution containing a noble metal precursor, drying I, calcining I, and treating with a hydrogen atmosphere to obtain a catalyst precursor; (3) mixing the catalyst precursor, molecular sieve, and additives, rolling to form spheres, drying II, calcining II, and reducing to obtain the catalyst.

The application discloses a preparation method of defect-induced synthesis of porous carbon nanocomposites and application thereof in supercapacitors. The method uses DHPC as a carbon base to anchor Mn3O4. A large number of intrinsic defects on the surface of the DHPC optimize the local electron density distribution and surface performance, accelerate ion kinetics, provide abundant nucleation sites, and enhance the binding activity with Mn3O4. The microwave-assisted synthesis technology is used to realize the uniform dispersion of Mn3O4 nanoparticles on the DHPC, forming a three-dimensional porous network structure. The structure not only improves the conductivity of Mn3O4, but also promotes the rapid diffusion of electrolyte ions and electron transmission, simultaneously relieves the stress damage in the charging and discharging process, and significantly improves the electrochemical performance and cycle stability of the material. Compared with the prior art, the preparation method has the advantages of simple operation, low cost, environmental friendliness and the like.

The application discloses a method for preparing normal paraffin, comprising the following steps: contacting isomeric alkanes and hydrogen with a catalyst in a reactor, and reacting to obtain normal paraffin; the isomeric alkanes are selected from at least one of isobutane and isopentane; the catalyst is composed of a double-layer spherical carrier and a noble metal active component loaded on the surface of the double-layer spherical carrier; and the noble metal active component is selected from at least one of platinum, palladium and gold.

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a letemovir key intermediate. According to the method, 2, 6-difluorobenzonitrile is taken as an initial raw material, and the 2-bromine-6-fluoroaniline is synthesized through four steps of reaction including ammonolysis, diazotization bromination, amidation and Hofmann degradation. The method is simple to operate, mild in condition, excellent in yield and quality and suitable for industrial production.

The present invention relates to the technical field of cycloserine intermediate synthesis, and specifically discloses a synthetic method of S-3-chloro-D-alanine methyl ester hydrochloride. Comprise the following steps: S1, D-serine is added to methanol, cooled to 5-10 DEG C, thionyl chloride is added dropwise, after the dropwise addition is completed, the temperature is raised to 30-50 DEG C for reaction for 10-24h, then ethyl acetate is added to the reaction mixture, stirred and crystallized for 0.5-2.0h, and filtered by suction to obtain D-serine methyl ester hydrochloride; S2, the above-mentioned D-serine methyl ester hydrochloride is added to dichloromethane, then thionyl chloride is added dropwise, the temperature is raised to 30-50 DEG C for reaction for 10-24h, methanol is added, heated to reflux for 0.5-2.0h, cooled and crystallized, filtered by suction, dried, and S-3-chloro-D-alanine methyl ester hydrochloride is obtained. The present method has mild reaction conditions, high product yield and purity, simple operation, and is convenient for industrial production.

The invention provides a method for preparing nano calcium carbonate through amine cycle by capturing carbon dioxide through ferronickel slag, and belongs to the technical field of waste resource utilization and carbon dioxide capture and utilization. The method comprises the following steps: mixing ferronickel slag powder with an ammonium chloride solution, and performing leaching reaction to obtain a mixed solution; adding ammonium hydroxide into the mixed solution to adjust the pH value, and filtering to obtain a leaching solution; introducing the flue gas into an ammonia water absorption tower to prepare an ammonium bicarbonate solution; the ammonium bicarbonate solution and the leachate are subjected to a carbonization reaction, nano calcium carbonate is obtained, ammonia gas generated by the carbonization reaction is recycled to an absorption tower to be reused, and a closed amine circulation system is formed. According to the amine circulation method, efficient utilization of CaO in the ferronickel slag can be achieved, meanwhile, CO2 in the flue gas is captured, the purity of obtained nano calcium carbonate is larger than or equal to 93%, the whiteness is larger than or equal to 94%, the nano calcium carbonate has the advantages of being small in particle size, good in dispersity and high in additional value, and cooperative utilization of high-additional-value recycling of the ferronickel slag and carbon dioxide emission reduction is achieved.

The application discloses a synthesis method of chiral amino alcohol compounds. The synthesis method of the chiral amino alcohol compounds comprises the following steps: in the presence of a carbonyl reductase and a coenzyme, a carbonyl compound shown as formula II is subjected to a reduction reaction shown as formula I in an organic solvent and a buffer solution to obtain a conversion solution containing the chiral amino alcohol compound shown as formula I. 1 The application uses a racemic aziridine chiral compound as a starting material, and through enzyme reaction of recombined carbonyl reductase, a single configuration chiral amino alcohol is efficiently synthesized, an important intermediate with a high de value is obtained, and production cost is reduced.

The invention discloses a method for preparing a naphthodiazepine indole derivative, which comprises the following steps: adding tri (dibenzylideneacetone) dipalladium (0)-chloroform adduct, bis (2-diphenylphosphinophenyl) ether and alkali into a reactor, adding a certain amount of solvent under the protection of argon, and stirring for a period of time; the preparation method comprises the following steps: dissolving N-(4-methylbenzenesulfonyl)-1-(2-indolyl)-2-naphthylamine and methyl (1-arylpropyl-2-alkyne-1-yl) carbonate in a certain amount of solvent, adding into a reactor, reacting at room temperature, and detecting that the reaction is complete by TLC (Thin Layer Chromatography). And after the reaction is finished, filtering, concentrating filtrate under reduced pressure, and performing column chromatography to obtain a pure product of the naphthodiazepine indole derivative. According to the technical scheme, the method has the characteristics of diversified substrate raw material sources, simple synthesis steps, mild reaction conditions, simplicity and convenience in operation, good reaction selectivity, complex and diversified target compound structures, and the like, and the product further contains olefin and amino functional groups for further structural modification.

The present application relates to a kind of drug synthesis process of Tovorafenib.The synthesis process described in the present application, the preparation method of chiral alpha-heteroamine involved, using biological catalyst amine dehydrogenase, directly under mild conditions, one-step reduction amination of latent chiral ketone is into optical pure chiral alpha-heteroamine, it can overcome the deficiency of existing catalytic technology, process route is simple, reaction condition is mild, yield is high, has the advantages, such as step economy, atom economy and other green synthesis, and the advantages, such as good stereoselectivity (ee value is as high as 99%).The condensation method of amino and carboxyl in the synthesis route described in the present application is mostly under HATU and alkaline environment, simple operation, high reaction yield, suitable for batch production.

The invention relates to the technical field of concrete, in particular to a novel amphoteric super-slow-release polycarboxylic acid slump retaining agent and a preparation method thereof. The method comprises the following steps: mixing and dissolving an unsaturated polyether macromonomer with water, adding a pH regulator, a first part of acrylic acid and an acrylic acid derivative, stirring, adding a first part of a reducing agent and an initiator, dropwise adding a dropwise adding solution A and a dropwise adding solution B at the same time, and carrying out a heat preservation reaction after dropwise adding is completed. The initiator is a composite initiation system composed of peroxides and azo; the dropping liquid A comprises a second part of acrylic acid, unsaturated carboxylic ester and phosphate monomers, and the dropping liquid B comprises a second part of a reducing agent and a chain transfer agent. According to the method, ordered copolymerization of multiple functional monomers is realized through a composite initiation and step-by-step dropwise adding process, and the prepared slump retaining agent has excellent initial dispersity and super-long slump retaining capacity, and is suitable for long-distance transportation and long-time construction concrete engineering.

This application discloses a method for converting C4-C5 isoalkanes. The method includes the following steps: in a reactor, a feedstock containing hydrogen and C4-C5 isoalkanes is contacted with a catalyst and reacted to obtain a product containing small-molecule hydrocarbons; the C4-C5 isoalkanes are selected from isobutane and / or isopentane; the small-molecule hydrocarbons are selected from at least one of ethane, propane, and n-butane; the catalyst is prepared by the following steps: (1) mixing molecular sieves, surfactants, and adhesives, and spheroidizing to obtain a catalyst precursor; (2) mixing the catalyst precursor with a mixture containing a metal element precursor, water, an additive, and boehmite, spheroidizing, drying, and calcining to obtain the catalyst.

The application belongs to the field of medicine, and discloses a kind of benzimidazole compounds containing electrophilic warhead and a preparation method and application thereof.The application provides a series of novel benzimidazole compounds containing electrophilic warhead, which has good targeting to TSPO, and part of the compounds shows good antiproliferative activity to tumor cells, and has potential anti-tumor research and development value.The benzimidazole compounds containing electrophilic warhead and pharmaceutically acceptable salts thereof have great application prospect in preparing anticancer drugs.The application further discloses a preparation method of the benzimidazole compounds containing electrophilic warhead, which is simple in operation, mild in conditions and suitable for implementation.

The invention discloses an angelica sinensis leftover material carbon quantum dot fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of preparation of carbon quantum dot fluorescent probes. The preparation method comprises the following steps: crushing cleaned and dried angelica leftover materials into angelica powder, taking the angelica powder as a carbon source, mixing the angelica powder with a boric acid solution in distilled water, carrying out a hydrothermal reaction, and after the reaction is finished, filtering, dialyzing and freeze-drying to obtain the angelica leftover material carbon quantum dot fluorescent probe. The angelica sinensis leftover material carbon quantum dot fluorescent probe is nearly spherical monodisperse nanoparticles, is uniform in particle size distribution and stable in fluorescent property, can detect Fe < 3 + > with high selectivity, shows good correlation to Fe < 3 + > in a relatively wide concentration range, and has a good application prospect in the field of Fe < 3 + > detection.

The application discloses a boron-containing electrolyte salt and a preparation and application thereof, and the preparation method of the boron-containing electrolyte salt comprises the following steps: I, adding boric acid, A + HCO3 ‑ , and water into a reaction container, stirring and mixing, then adding salicylic acid, obtaining a boron-containing electrolyte salt reaction liquid after reaction, and obtaining a product, the boron-containing electrolyte salt, through post-treatment of the boron-containing electrolyte salt reaction liquid; the A + is a 1-ethyl-3-methyl imidazole cation or a 1,2,3,4-tetramethyl imidazoline cation. The boron-containing electrolyte salt can be applied to a capacitor electrolyte as an electrolyte additive. The application has the advantages that a novel boron-containing electrolyte salt structure which can be applied to a capacitor electrolyte as an electrolyte additive is provided, the boron electrolyte salt has a simple synthesis process route, mild reaction conditions, convenient operation, high product purity, high yield, and high industrial utilization value.

The invention relates to an antibiotic-free biological fermentation compound feed for poultry and a preparation method thereof, and belongs to the technical field of feeds, the feed takes a fermentation basic raw material as a carrier, plant extracts and chemical addition components are added, and the synergistic effects of resisting bacteria, diminishing inflammation, regulating intestinal flora, promoting nutrient absorption and improving the immunity of poultry are achieved in a biological fermentation synergistic manner; and antibiotic residues are avoided, so that the safety of poultry products is guaranteed.

The invention discloses a naphthalene ring derivative, a synthesis method and application, and provides a series of novel naphthalene ring derivatives substituted by different functional groups. Compared with the existing naphthalene ring derivative, the naphthalene ring derivative provided by the invention is a functional group substituted naphthalene ring, and is easily subjected to subsequent chemical conversion and further converted into a high-added-value compound. According to the efficient synthesis method of the naphthalene ring derivative, the substrate applicability is wide, raw materials are cheap, synthesis is easy, high temperature and use of a catalyst are not needed in the reaction process, and various substituent-substituted naphthalene ring compounds can be prepared. The reaction process is milder, the safety is high, the post-treatment difficulty is reduced, high temperature and high pressure are not needed, only visible light irradiation is needed, meanwhile, the use of expensive metal catalysts and organic photocatalysts is avoided, and the post-treatment difficulty is reduced. The method also has the advantages of simple operation, simple steps, high yield, large-scale synthesis and the like.