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Tendon reinforcing repairing material and preparation method thereof

A technology of repair materials and composite materials, which is applied in the field of tendon-reinforced repair materials and its preparation, which can solve the problems of destroying the biocompatibility of the final product, inability to strengthen tendon repair, and limited ability of tissue regeneration, etc., to achieve the reduction of immunogen Safety and safety risks, increase anti-adhesion effect, and large coverage effect

Active Publication Date: 2015-05-27
SHAANXI RUISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is made of bovine tendon tissue as the base material. After the extraction process, the type I collagen with a protein purity of more than 95% is made by freeze-drying process with pores of 80-200 μm. Due to its low mechanical properties, it can only be used for covering Suturing the treated tendon during the operation cannot serve the purpose of tendon reinforcement and repair
Chinese patent application 200710068761.0 made absorbable polymer materials and collagen and other materials into two layers of membranes with large and small apertures, and then compounded to enhance mechanical properties. Although collagen materials can also provide scaffolding, they are easily degraded in the body. limited ability to regenerate tissue
Although this method realizes the cross-linking combination of collagen scaffolds and growth factors, the residual reagents of secondary cross-linking and the impact on scaffold materials will destroy the biocompatibility of the final product.

Method used

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  • Tendon reinforcing repairing material and preparation method thereof
  • Tendon reinforcing repairing material and preparation method thereof
  • Tendon reinforcing repairing material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Step 1. Raw material processing: Remove the subcutaneous tissue from the newborn cowhide, wash it with pure water, remove the epidermis and basement membrane, cut it to a thickness of 0.3mm, soak it in medical alcohol for 1 hour, and transfer it to 4°C normal saline Soak to obtain the treated skin and set aside;

[0042] Step 2. Preparation of the scaffold layer of the tendon reinforcement repair material: place the treated skin obtained in step 1 in an aqueous solution containing 0.5% Triton X-100, shake at 4°C for 4 hours; put it in a 0.5mol / L NaCl aqueous solution for later use Shake at room temperature for 32 hours; obtain the decellularized bovine dermal matrix, that is, the scaffold layer of the tendon-reinforced repair material;

[0043] Step 3. Preparation of the mechanical reinforcement layer of the tendon reinforcement repair material: prepare a polylactic acid solution with a mass volume ratio of 5%, and compound the polymer on one surface of the decellulariz...

Embodiment 2

[0056] Step 1. Raw material processing: Remove the subcutaneous tissue from the newborn cowhide, wash it with pure water, remove the epidermis and basement membrane, cut it to a thickness of 0.5mm, soak it in medical alcohol for 2 hours, and transfer it to 4°C normal saline Soak to obtain the treated skin and set aside;

[0057] Step 2. Preparation of scaffold layer of tendon reinforcement repair material: place the treated skin obtained in step 1 in an aqueous solution containing 1% Triton X-100, shake at 4°C for 8h; then place in 10mM EDTA aqueous solution and shake at room temperature for 32h Obtain the decellularized bovine dermis matrix, that is, the scaffold layer of the tendon reinforcement repair material;

[0058]Step 3. Preparation of the mechanical reinforcement layer of the tendon reinforcement repair material: prepare a polylactic acid solution with a mass volume ratio of 5%, and compound the polymer on one surface of the decellularized bovine dermis matrix scaffo...

Embodiment 3

[0062] Step 1. Raw material processing: Remove the subcutaneous tissue of the adult pigskin, wash it with pure water, remove the epidermis and basement membrane, cut it to a thickness of 0.8mm, soak it in medical alcohol for 2 hours, and then transfer it to 4°C Soak in normal saline, get the treated skin, and set aside;

[0063] Step 2. Preparation of the scaffold layer of the tendon reinforcement repair material: place the treated skin obtained in step 1 in an aqueous solution containing 0.1% SDS, shake at 25°C for 3h; then put it in a 0.5mol / L NaCl aqueous solution and shake at room temperature for 32h Obtain the decellularized porcine dermal matrix, that is, the scaffold layer of the tendon reinforcement repair material;

[0064] Step 3. Preparation of the mechanical reinforcement layer of the tendon reinforcement repair material: prepare a polycaprolactone solution with a mass volume ratio of 6%, and compound the polymer on one surface of the acellular porcine dermal matri...

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Abstract

The invention relates to a tendon reinforcing repairing material and a preparation method of the tendon reinforcing repairing material. The repairing material takes animal original dermis as the raw material and is prepared by steps of pretreatment, preparation of a holder layer, preparation of a mechanical reinforcing layer, and preparation of a tendon reinforcing repairing material. The tendon reinforcing material comprises the holder layer and the mechanical reinforcing layer, wherein the holder layer reserves the integrity of the structure and component of an extracellular matrix to the greatest degree, and due to the introduction of the mechanical reinforcing layer, the acellular dermal matrix has better mechanical property compared with the acellular dermal matrix prepared by the traditional technology, for the biocompatibility, mechanical strength and biological activity are improved and balanced. According to the requirements of different indications on materials, the preparation method can prepare membrane materials and curl materials in different thicknesses. The tendon reinforcing repairing material is widely applicable to repairing of acute and old tendon injury.

Description

technical field [0001] The invention belongs to medical biomaterial technology, and in particular relates to a tendon reinforcement repair material and a preparation method thereof. Background technique [0002] Tendon is a strong connective tissue connecting muscle and bone, mainly composed of collagen bundles and aponeurotic structures. Tendon injuries can be direct or indirect, both of which can seriously affect motor function. Tendon ruptures are often located in areas prone to tendon degeneration. Acute tendon rupture can be sutured directly; if the old tendon rupture is not treated in time in the early stage, it is easy to cause retraction of the tendon stump, adhesion and scar formation between the stump and the surrounding tissue, and it is difficult to fit after surgical scar removal and repair of the stump , so tenoplasty or augmentation repair is required. The aging situation in my country is intensifying, and the seriousness and late stage of old tendon ruptur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/50
Inventor 郜香黎姚阳
Owner SHAANXI RUISHENG BIOTECH
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