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Halloysite nano composite gel microspheres and preparation method thereof

A technology of nanocomposite and gel microspheres, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of complex carrier preparation process and high cost of carbon nanotube preparation , cytotoxicity and other issues, to achieve the effects of slowing down the drug release rate, good pH responsiveness, and slowing down the swelling rate

Active Publication Date: 2014-01-22
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recent studies have shown that the use of carbon nanotubes as drug release carriers still has the following problems: (1) it has certain side effects, can produce cytotoxicity, cause cell apoptosis and cause aspiration pneumonia; Surface modification under harsh conditions can introduce functional groups on the surface, thereby improving the dispersion stability of carbon nanotubes and loading target drug molecules. The carrier preparation process and process are complicated; (3) The cost of carbon nanotube preparation is high, The process is complex and expensive
However, like other clays, halloysite nanotubes are simply used as drug carriers, and there are also problems such as single surface functional groups, poor dispersion stability, and low drug loading efficiency.

Method used

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  • Halloysite nano composite gel microspheres and preparation method thereof
  • Halloysite nano composite gel microspheres and preparation method thereof
  • Halloysite nano composite gel microspheres and preparation method thereof

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Effect test

Embodiment 1

[0026] At 1000 rpm, halloysite was added to water to prepare a suspension with a concentration of 5%; at 1000 rpm, carboxymethyl chitosan was dissolved in water to prepare a suspension with a concentration of 3%. glue solution. The halloysite suspension was added into the carboxymethyl chitosan gel solution at 1000 rpm and stirred for 1 h, and then ultrasonically treated at a power of 100 w and a frequency of 60 kHz for 30 min. At 500 rpm, drop the mixed solution into 5% calcium chloride solution with a syringe, stir for 3 hours, filter the nanocomposite gel particles, rinse with distilled water, and vacuum dry to obtain halloysite nanocomposite gel microspheres . The nanocomposite gel microspheres have a diameter of 2-4 mm, hardly swell at pH=2, and have a swelling ratio of 50 at pH=6.8.

Embodiment 2

[0028] At 1000 rpm, halloysite was added to water to prepare a suspension with a concentration of 5%; at 1000 rpm, carboxymethyl chitosan was dissolved in water to prepare a suspension with a concentration of 3%. glue solution. Add the halloysite suspension into the carboxymethyl chitosan gel solution at 1000 r / min, add diclofenac sodium at the same time and stir for 1 hour, then ultrasonicate for 30 minutes at a power of 100w and a frequency of 60kHz. At 500 rpm, drop the mixed solution into 5% calcium chloride solution with a syringe, stir for 3 hours, filter the nanocomposite gel particles, rinse with distilled water, and vacuum dry to obtain halloysite nanocomposite gel microspheres . At pH=1.2, almost no drug was released, but at pH=6.8, the 24h drug release rate reached 85%.

Embodiment 3

[0030] At 1000 rpm, halloysite was added to water to prepare a suspension with a concentration of 7%; at 1000 rpm, quaternary ammonium chitosan was dissolved in water to prepare a suspension with a concentration of 3%. glue solution. At 1000 rpm, the halloysite suspension was added into the quaternary ammonium chitosan gel solution and stirred for 1 h, and then ultrasonically treated at a power of 100 w and a frequency of 60 kHz for 30 min. At 500 rpm, drop the mixed solution into 5% calcium chloride solution with a syringe, stir for 3 hours, filter the nanocomposite gel particles, rinse with distilled water, and vacuum dry to obtain halloysite nanocomposite gel microspheres . The nanocomposite gel microspheres have a diameter of 3-4 mm, hardly swell at pH=2, and have a swelling ratio of 46 at pH=6.8.

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Abstract

The invention discloses halloysite nano composite gel microspheres and a preparation method thereof. The microspheres comprise the following components in percentage by mass: 50-90% of halloysite and 10-50% of a chitosan derivative. The preparation method comprises the following steps: firstly, preparing the halloysite and the chitosan derivative into a suspension and a gel solution respectively; then adding the halloysite suspension into the chitosan derivative gel solution; and finally, after 2-4 hours of reaction at room temperature, preparing the nano composite drug-loaded gel microspheres through an ion-gel method. According to the halloysite nano composite gel microspheres and the preparation method thereof disclosed by the invention, the swelling rate and drug release rate of the microspheres can be reduced, and the halloysite nano composite gel microspheres have pH sensitivity and can be used as intestinal drug slow-release carriers.

Description

technical field [0001] The invention relates to nanomaterials used in the pharmaceutical field and a preparation method thereof, in particular to halloysite nanocomposite gel microspheres and a preparation method thereof. Background technique [0002] In recent years, in order to control the adverse reactions caused by some anticancer drugs and anti-inflammatory drugs when taken orally, and at the same time ensure that the active components of the drug reach the target location and maintain a stable blood concentration for a long time, many researchers combine drugs with Appropriate carriers are combined to form an effective drug controlled release system, which can control the release of drugs and improve the therapeutic effect. Currently, carriers for drug controlled release include materials such as carbon biomacromolecules, nanotubes, and clays. [0003] Due to their unique nanometer size and tubular structure, carbon nanotubes have become a research hotspot in the fiel...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/36A61K47/34A61K31/196A61K31/513
Inventor 汪琴张俊平王爱勤
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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