Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof

A technology of glycolic acid copolymers and micro-nano particles, applied in the field of biomedical applications, can solve problems such as poor stability, isomerization transformation, and limited applications, and achieve the effect of improving solubility and reducing side effects

Inactive Publication Date: 2014-01-22
NANJING NORMAL UNIVERSITY
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of resveratrol in water is only 0.0169mg / mL, and it will undergo isomerization transformation under ultraviolet light irradiation
Low water solubility and poor stability after ultraviolet irradiation greatly limit its application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof
  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof
  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Add polylactic acid-glycolic acid copolymer (4mg) and resveratrol (4mg) into the reaction flask, and add tetrahydrofuran (6ml) and acetone (4ml), after fully dissolving, add distilled water (10ml) under rapid stirring. Continue to stir the obtained mixture, quickly volatilize the organic solvent, then centrifuge and wash with deionized water to remove free resveratrol, remove the supernatant after centrifugation, collect the precipitate, and obtain the resveratrol-loaded polymer after drying. Lactic acid-glycolic acid copolymer micro-nanoparticles. After the product was dried, infrared detection was carried out, such as figure 1 shown. Utilize ultraviolet spectrophotometry to detect the drug release situation of this product in phosphate buffer solution, as image 3 Shown, after 107 hours, release 51%. The transmission electron microscopy data of the prepared micro-nanoparticles (the mass ratio of polylactic acid-glycolic acid copolymer to resveratrol is 1:1) is as f...

Embodiment 2

[0023] Add polylactic acid-glycolic acid copolymer (4mg) and resveratrol (0.4mg) into the reaction bottle, and add tetrahydrofuran (6ml) and acetone (4ml), after fully dissolved, add the water phase (10ml ). Continue to stir the obtained mixture, quickly volatilize the organic solvent, then centrifuge and wash with deionized water to remove free resveratrol, remove the supernatant after centrifugation, collect the precipitate, and obtain the resveratrol-loaded polymer after drying. Lactic acid-glycolic acid copolymer micro-nanoparticles. After the product was dried, infrared detection was carried out, such as figure 2 shown. Utilize ultraviolet spectrophotometry to detect the drug release situation of this product in phosphate buffer solution, as Figure 4 Shown, after 107 hours, release 49%. The transmission electron microscopy data of the prepared resveratrol-loaded polylactic acid-glycolic acid copolymer micro-nanoparticles (the mass ratio of polylactic acid-glycolic a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and a preparation method thereof. The micro-nano particles are composed of resveratrol and a carrier material poly(lactic-co-glycolic acid), the particle size is in micro-nano grade, and the mass ratio of poly(lactic-co-glycolic acid) to resveratrol is 1:0.1-1. A solution of the resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles is prepared by employing a simple rapid ' ' one-step phase separation ' ' method, and is subjected to centrifugation drying, the micro-nano particles are collected. The operation technological route is simple, less in energy consumption and none in pollution, and provides new thinking for safer and more efficient application of resveratrol to clinic and preparation of poly(lactic-co-glycolic acid) novel composite materials.

Description

technical field [0001] The invention relates to a method for preparing resveratrol-loaded polylactic acid-glycolic acid copolymer micro-nano particles by a phase separation method, and its application in the field of biomedicine. Background technique [0002] Nano-drug delivery system refers to the use of nano-carriers (in a broad sense, particles with a size below 1000nm) to coat and transport drugs, so as to achieve the purpose of controlling drug release. Compared with the free drug, the nano-microspheres encapsulating the drug can enhance the therapeutic effect and prolong the half-life of the drug, thereby enhancing the bioavailability of the drug. [0003] Polylactic acid-glycolic acid copolymer, which is a copolymer formed by polymerizing glycolic acid and lactic acid in a certain proportion, has been approved by the US FDA and is currently considered to be one of the most mature in vivo degradable polymers. Polylactic acid-glycolic acid copolymer has excellent bioco...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/52A61K9/51A61K31/05A61K47/34A61P35/00A61P31/04A61P39/06A61P9/00A61P5/30
Inventor 沈健毛春苗静静宋幼超刘鹏程
Owner NANJING NORMAL UNIVERSITY
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com