Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof

A technology of glycolic acid copolymers and micro-nano particles, applied in the field of biomedical applications, can solve problems such as poor stability, isomerization transformation, and limited applications, and achieve the effect of improving solubility and reducing side effects

Inactive Publication Date: 2014-01-22
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of resveratrol in water is only 0.0169mg/mL, and it will undergo isomerization transformation under ul

Method used

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  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof
  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof
  • Resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1

[0017] Add polylactic acid-glycolic acid copolymer (4mg) and resveratrol (4mg) into the reaction flask, and add tetrahydrofuran (6ml) and acetone (4ml). After fully dissolving, add distilled water (10ml) under rapid stirring. Continue to stir the obtained mixture to quickly evaporate the organic solvent, and then centrifuge with deionized water to remove the free resveratrol. After centrifugation, the supernatant is removed and the precipitate is collected. After drying, the resveratrol-loaded polymer can be obtained. Lactic acid-glycolic acid copolymer micro-nano particles. After drying the product, perform infrared detection, such as figure 1 Shown. Use ultraviolet spectrophotometry to detect the drug release of the product in phosphate buffer, such as image 3 As shown, after 107 hours, 51% was released. TEM data of the prepared micro-nano particles (the mass ratio of polylactic acid-glycolic acid copolymer and resveratrol is 1:1) as Figure 5 Shown. The ...

Example Embodiment

[0022] Example 2

[0023] Add polylactic acid-glycolic acid copolymer (4mg) and resveratrol (0.4mg) into the reaction flask, and add tetrahydrofuran (6ml) and acetone (4ml). After fully dissolving, add the water phase (10ml) under rapid stirring. ). Continue to stir the obtained mixture to quickly evaporate the organic solvent, and then centrifuge with deionized water to remove the free resveratrol. After centrifugation, the supernatant is removed and the precipitate is collected. After drying, the resveratrol-loaded polymer can be obtained. Lactic acid-glycolic acid copolymer micro-nano particles. After drying the product, perform infrared detection, such as figure 2 Shown. Use ultraviolet spectrophotometry to detect the drug release of the product in phosphate buffer, such as Figure 4 As shown, after 107 hours, 49% was released. The TEM data of the prepared resveratrol-loaded polylactic acid-glycolic acid copolymer micro-nanoparticles (the mass ratio of polylactic acid-gly...

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Abstract

The invention relates to resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles and a preparation method thereof. The micro-nano particles are composed of resveratrol and a carrier material poly(lactic-co-glycolic acid), the particle size is in micro-nano grade, and the mass ratio of poly(lactic-co-glycolic acid) to resveratrol is 1:0.1-1. A solution of the resveratrol-supporting poly(lactic-co-glycolic acid) micro-nano particles is prepared by employing a simple rapid ' ' one-step phase separation ' ' method, and is subjected to centrifugation drying, the micro-nano particles are collected. The operation technological route is simple, less in energy consumption and none in pollution, and provides new thinking for safer and more efficient application of resveratrol to clinic and preparation of poly(lactic-co-glycolic acid) novel composite materials.

Description

technical field [0001] The invention relates to a method for preparing resveratrol-loaded polylactic acid-glycolic acid copolymer micro-nano particles by a phase separation method, and its application in the field of biomedicine. Background technique [0002] Nano-drug delivery system refers to the use of nano-carriers (in a broad sense, particles with a size below 1000nm) to coat and transport drugs, so as to achieve the purpose of controlling drug release. Compared with the free drug, the nano-microspheres encapsulating the drug can enhance the therapeutic effect and prolong the half-life of the drug, thereby enhancing the bioavailability of the drug. [0003] Polylactic acid-glycolic acid copolymer, which is a copolymer formed by polymerizing glycolic acid and lactic acid in a certain proportion, has been approved by the US FDA and is currently considered to be one of the most mature in vivo degradable polymers. Polylactic acid-glycolic acid copolymer has excellent bioco...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/51A61K31/05A61K47/34A61P35/00A61P31/04A61P39/06A61P9/00A61P5/30
Inventor 沈健毛春苗静静宋幼超刘鹏程
Owner NANJING NORMAL UNIVERSITY
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