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Potassium magnesium aspartate composition freeze-dried powder for injection

A technology of potassium magnesium aspartate and freeze-dried powder injection, which is applied in the direction of freeze-dried delivery, drug combination, powder delivery, etc., can solve the problem of not containing chitosan nanoparticles, so as to improve bioavailability and ensure safety Sexuality, the effect of reducing the frequency of use

Active Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no pharmaceutical dosage form containing chitosan nanoparticles clinically at present.

Method used

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  • Potassium magnesium aspartate composition freeze-dried powder for injection
  • Potassium magnesium aspartate composition freeze-dried powder for injection
  • Potassium magnesium aspartate composition freeze-dried powder for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 potassium magnesium aspartate composition freeze-dried powder for injection (with 2000)

[0022] 1. Prescription

[0023]

[0024] 2. Preparation process

[0025] (1) Weigh 850g of potassium magnesium aspartate, 160g of potassium hydroxide (the rest is used for pH adjustment), 70g of magnesium oxide, and 500g of chitosan nanoparticles, slowly add 7200mL of 70°C water for injection, and stir while adding until dissolved.

[0026] (2) Use KOH to adjust the pH to 8.0, add water for injection to the resulting solution to the full amount, then add 0.2 g of activated carbon and stir for 30 minutes, filter the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect intermediates The content is calculated as 1.0g per bottle (calculated as potassium magnesium aspartate).

[0027] (3) Fill according to the testing requirements, put it into a freeze dryer after half-tightening, cool down to -40°C±2°C...

Embodiment 2

[0028] Embodiment 2 Preparation of Potassium Magnesium Aspartate Composition Freeze-dried Powder for Injection (with 2000)

[0029] 1. Prescription

[0030]

[0031] 2. Preparation process

[0032] (1) Weigh 850g of potassium magnesium aspartate, 160g of potassium hydroxide (the rest is used for pH adjustment), 70g of magnesium oxide, and 500g of chitosan nanoparticles, slowly add 7200mL of 70°C water for injection, and stir while adding until dissolved.

[0033] (2) Use KOH to adjust the pH to 8.0, add water for injection to the resulting solution to the full amount, then add 0.2 g of activated carbon and stir for 30 minutes, filter the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect intermediates The content is calculated as 1.0g per bottle (calculated as potassium magnesium aspartate).

[0034] (3) Fill according to the test requirements, put it into a freeze dryer after half-tightening, cool down to -40°C±2°C, keep ...

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Abstract

The invention provides a potassium magnesium aspartate composition freeze-dried powder for injection, and belongs to the field of medicine and medicine preparation technology. The potassium magnesium aspartate composition freeze-dried powder comprises following raw material ingredients, by weight, 850 to 1700 parts of potassium magnesium aspartate, 164 to 328 parts of potassium hydroxide, 70 to 140 parts of magnesium oxide, 500 to 1000 parts of chitosan nanoparticle, and 4000 to 8000 parts of injection water. Advantages of the potassium magnesium aspartate composition freeze-dried powder are that: the potassium magnesium aspartate composition is made into freeze-dried powder for convenience in clinical application; the potassium magnesium aspartate composition is capable of prolonging medicine half-life period significantly, prolonging medicine action time, increasing medicine bioavailability, and reducing medicine use numbers of patient; the potassium magnesium aspartate composition freeze-dried powder injection is stable in properties, is convenient for carrying and transporting, and is capable of reducing dosage of the auxiliary materials, improving solubility of the main medicine ingredient, and ensuring clinical medication safety.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a freeze-dried powder injection of potassium magnesium aspartate composition for injection. Background technique: [0002] Aspartate is the precursor of oxaloacetate in the body and plays an important role in the Krebs cycle. At the same time, aspartic acid also participates in the ornithine cycle, promotes the metabolism of ammonia and carbon dioxide, makes it generate urea, and reduces the content of ammonia and carbon dioxide in the blood. Aspartic acid has a strong affinity for cells. After it combines with potassium ions and magnesium ions, it forms stable potassium salts and magnesium salts, so that aspartic acid becomes the carrier of potassium and magnesium ions and allows these two ions to enter the body cells. Inside. Potassium magnesium aspartate participates in the ornithine cycle, making NH3 and CO2 generate urea to achieve detoxification...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/08A61K47/36A61K9/19A61P1/16A61P31/12A61P35/00A61K31/198A61K33/00
Inventor 汪六一汪金灿林立
Owner HAINAN WEI KANG PHARMA QIANSHAN