A kind of immune adjuvant of chicken infectious bursal disease live vaccine effervescent tablet

An immune adjuvant and bursal disease technology, applied in the direction of allergic diseases, organic active ingredients, plant raw materials, etc., can solve the problems of high mortality, large losses, and small chicks, so as to reduce the risk of infection and improve the use of Effect, effect of reducing stress response

Active Publication Date: 2015-09-30
浙江美保龙生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, this disease can lead to symptoms such as weight loss, slow growth, and skeletal muscle hemorrhage. Under the condition of poor sanitation, it is often accompanied by other diseases, and the mortality rate is further increased. The chicks are small and have poor disease resistance. Once the epidemic occurs, Then the infection is fast, the mortality rate is high, the mortality rate reaches more than 80%, and the loss is even greater, which brings huge economic losses to the chicken industry.

Method used

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  • A kind of immune adjuvant of chicken infectious bursal disease live vaccine effervescent tablet
  • A kind of immune adjuvant of chicken infectious bursal disease live vaccine effervescent tablet
  • A kind of immune adjuvant of chicken infectious bursal disease live vaccine effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the preparation of Chinese medicine polysaccharide and Chinese medicine flavone

[0027] a. Weigh 20 parts of Andrographis paniculata, 30 parts of Achyranthes bidentata, 20 parts of Poria cocos, 10 parts of Radix Radix, 10 parts of licorice, 30 parts of nettle, 20 parts of Vitex radix, and 30 parts of Astragalus membranaceus, chop and wash Soak in cold water overnight, then add purified water 15 times the weight of the raw material, take a water bath to 90°C, and keep it at 90°C, cook for 2 hours, and stir every 10 minutes during the cooking process;

[0028] b. Discard the dregs of the traditional Chinese medicine in a, collect the medicinal liquid, and centrifuge at 10,000 rpm for 10 minutes after cooling at room temperature, discard the precipitate, and collect the supernatant;

[0029] c. The supernatant in b is subjected to alcohol precipitation, the precipitation is the crude Chinese medicine polysaccharide, and the supernatant is the crude Chinese m...

Embodiment 2

[0034] Embodiment 2: the preparation of Chinese medicine polysaccharide and Chinese medicine flavone

[0035] Change the traditional Chinese medicine composition in step a of Example 1 to 10 parts of Andrographis paniculata, 20 parts of Achyranthes bidentata, 15 parts of Poria cocos, 25 parts of Radix Radix, 25 parts of licorice, 10 parts of nettle, 15 parts of Vitex japonica and 25 parts of Astragalus, other The step conditions are all the same as in Example 1.

Embodiment 3

[0037] Change the traditional Chinese medicine composition in step a of Example 1 to 30 parts of Andrographis paniculata, 40 parts of Achyranthes bidentata, 10 parts of Poria cocos, 30 parts of Radix Radix, 30 parts of licorice, 20 parts of nettle, 10 parts of Vitex japonica and 15 parts of Astragalus, other The step conditions are all the same as in Example 1.

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Abstract

The invention discloses an effervescent tablet immunologic adjuvant for a chicken infectious bursal disease live vaccine, which belongs to the technical field of veterinary biological products. The effervescent tablet immunologic adjuvant in each 1,000 ml of phosphate buffer comprises the following components: 30-80 g of traditional Chinese medicine polysaccharide, 20-50 g of traditional Chinese medicine flavonoid, 6-10 g of vitamins, 4-6 g of gelatin and 40-70 g of cane sugar. The effervescent tablet immunologic adjuvant disclosed by the invention has the advantages that the immunologic adjuvant has a heat resistant effect and is capable of improving the convenience for vaccine transportation, storage and the like; when a vaccine prepared from the immunologic adjuvant is adopted during inoculation, the stress reaction can be alleviated and the disease infection risk of chicken flocks is reduced; when the immunologic adjuvant is used for preparing the vaccine, the use effect of the live vaccine can be greatly improved and a neutralizing antibody is quickly produced.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and in particular relates to an immune adjuvant for chicken infectious bursal disease live vaccine effervescent tablet. Background technique [0002] With the rise of intensive poultry farming and the increase of international trade, poultry diseases are becoming more and more serious, resulting in high mortality of poultry, which seriously restricts the development of the poultry industry, causes serious losses to the world's poultry industry, and endangers economic development, food security and social stability. Chicken infectious bursal disease (Infection bursal disease, IBD) is a highly contagious disease of chickens and turkeys caused by infectious bursal virus (Infection bursal disease virus, IBDV). For young chickens at the age of one week, the virus mainly proliferates in the lymphocytes of the bursa of Fabricius, and causes varying degrees of damage to other immu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/484A61K9/46A61K39/39A61P37/04A61K31/593A61K31/525A61K31/51A61K31/375A61K31/355A61K31/715
Inventor 张秀文李阳闫艳丽刘雪王二先盛璐丝
Owner 浙江美保龙生物技术有限公司
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