Composite porous fiber with core-shell structure and preparation method of double-porous membrane

Abstract

The invention discloses a preparation method of high-conductivity hollow porous composite fibers which take a conductive polymer as a shell and a degradable polymer as a core and have core-shell structures, and a dual-pore structure membrane of the high-conductivity hollow porous composite fibers as well as an application of the dual-pore structure membrane in tissue engineering. The preparation method comprises the steps of preparing the degradable polymer, hollow fibers with porous surfaces and the dual-pore structure membrane through an electrostatic spinning method, preparing a degradable polymer / conductive high polymer, hollow porous composite fibers and a dual-pore structure membrane thereof through an in-situ polymerization method, and cleaning and drying to obtain the high-conductivity hollow porous composite fibers with the core-shell structures and the dual-pore structure membrane of the high-conductivity hollow porous composite fibers. The high-conductivity composite micron / nano-fiber dual-pore structure membrane prepared by the invention can be applied to nerve tissue engineering, has the advantages of high conductivity, high porosity, large pore size and good chemical stability, and has a practical value in nerve tissue engineering, and the preparation method of the membrane is simple and feasible.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a high-conductivity composite porous fiber with a core-shell structure with a conductive polymer as the shell and a degradable polymer as the core and a preparation method for the double-pore structure membrane. Background technique [0002] In vitro and in vivo experiments have shown that electrically active biomaterials can stimulate the regeneration of bone cells and nerve cells (Biomaterials2001; 22: 1055). So far, polypyrrole, polyaniline and other conductive polymers are widely studied as electroactive biomaterials that can be used as substrates. In particular, polypyrrole has shown potential in biomedical applications. Its unique electrical activity, conductivity and biocompatibility to mammalian cells make it ideal for nerve repair and guided nerve regeneration. Guide channel material (J.Biomed.Mater.Res.A2000, 50:574-583). However, due to the fragility, rigidity and non-b...

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Problems solved by technology

Therefore, the combination of electrospinning technology and in-situ polymerization method has not been seen so far to prepare electroactive polylactic acid / polypyrrole composite micro / nanofiber double-pore structure with large voids interwoven by composite fibers with core-shell structure. Film related reports

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