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Preparation method for calcite type calcium carbonate and sodium alginate hybrid particles

A technology of sodium alginate and hybrid particles, which is applied in the directions of non-active ingredient medical preparations, pharmaceutical formulations, and pharmaceutical sciences, can solve the problems of uneven particle size distribution of microspheres, long reaction time, environmental pollution, etc. Good biodegradability and biocompatibility, short reaction time, simple and easy preparation process

Inactive Publication Date: 2014-02-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microspheres prepared by these methods have a wide controllable range of particle size and are suitable for drug embedding. However, the particle size distribution of the prepared microspheres is relatively uneven, and organic solvents are often added during the reaction process, so the operation is relatively complicated. The reaction time is long, and it will cause some pollution to the environment

Method used

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  • Preparation method for calcite type calcium carbonate and sodium alginate hybrid particles
  • Preparation method for calcite type calcium carbonate and sodium alginate hybrid particles
  • Preparation method for calcite type calcium carbonate and sodium alginate hybrid particles

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0029] (1) Dissolve 5g of sodium alginate in 1000mL of distilled water at 70°C to obtain a 0.5g / L sodium alginate solution;

[0030] (2) Weigh 53g of anhydrous sodium carbonate into a 1L volumetric flask, add distilled water to prepare a 0.5mol / L sodium carbonate solution;

[0031] (3) Weigh 55.5g of anhydrous calcium chloride and add it to a 1L volumetric flask, add distilled water to prepare a 0.5mol / L calcium chloride solution;

[0032] (4) Take 20mL of the sodium alginate solution described in (1) and add it to a 100ml beaker. At the same time, take the same volume of the sodium carbonate solution described in (2) and add it to the beaker, and sonicate for ten minutes;

[0033] (5) Take 20ml of the calcium chloride solution described in (3), drop by drop into the mixture described in (4), and sonicate for one hour under the same conditions;

[0034] (6) Put the final mixture into a centrifuge, centrifuge at 8000r / min for ten minutes, and put the obtained particles into a ...

Embodiment 2

[0036] (1) Weigh 0.1g of diclofenac sodium drug powder into a 100ml volumetric flask, add distilled water to prepare a 1mg / ml diclofenac sodium aqueous solution;

[0037] (2) Take 10mL of the sodium alginate solution described in Example 1, and add it to No. 1, No. 2, No. 3, No. 4, No. 5, and No. 6 100ml beakers, and at the same time take the same volume of the sodium alginate solution in Example 1. Said sodium carbonate solution was added in 6 beakers, ultrasonic ten minutes;

[0038] (3) Take 10ml of the calcium chloride solution described in Example 1 and add it to No. 1, No. 2, No. 3, No. 4, No. 5 and No. 6 50ml beakers, and take 2ml, 4ml, 6ml, 8ml, Add 10ml of diclofenac sodium solution into No. 1, No. 2, No. 3, No. 4, and No. 5 beakers filled with calcium chloride solution, and also sonicate for ten minutes to make them evenly mixed;

[0039] (4) Add the mixed solution in the 6 beakers mentioned in (3) drop by drop into the corresponding numbered beaker in (2), and soni...

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Abstract

The invention relates to a preparation method for calcite type calcium carbonate and sodium alginate hybrid particles. The preparation method comprises the following steps: dissolving sodium alginate in a solvent at a temperature ranging from 70 DEG C to 80 DEG C to obtain a sodium alginate solution; preparing a sodium carbonate solution and a calcium chloride solution at the indoor temperature; adding the sodium alginate solution into the sodium carbonate solution and performing ultrasonic processing to obtain a mixed liquor; dripping the calcium chloride solution into the mixed liquor, and performing ultrasonic, centrifugation and drying processing to obtain the hybrid particles. The invention has the advantages that the preparation conditions are moderate, the preparation process is simple and easy to implement, and the obtained hybrid particles have uniform diameters.

Description

technical field [0001] The invention belongs to the field of preparation of hybrid granular materials, in particular to a method for preparing calcite type calcium carbonate-sodium alginate hybrid particles. Background technique [0002] Calcium carbonate is the main inorganic component of limestone, which is used in large quantities in the construction industry and is an important raw material for many industries. In addition, because of its good biological activity and biodegradability, non-toxicity and good biocompatibility, it has potential application prospects in pharmacy, biology and medicine. [0003] As we all know, sodium alginate and calcium ions can gel at room temperature to form a sodium alginate gel with an eggshell structure. Calcium alginate has good biocompatibility, bioadhesion and biodegradability, and more importantly, it also has the advantages of non-toxicity, pH sensitivity and mild preparation conditions. Sodium alginate gel microspheres are used as...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/02A61L15/28A61L15/18A61L15/42
Inventor 朱利民侯晓晓孙晓竹
Owner DONGHUA UNIV