Unlock instant, AI-driven research and patent intelligence for your innovation.
Application of depside derivatives
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of use and medicine, applied in the field of depsidic acid derivatives, can solve the problems of flatulence, diarrhea, hypoglycemia, cardiotoxicity, etc., and achieve the effects of reducing fasting blood sugar, improving lipid metabolism, and good hypoglycemic and lipid-lowering activities
Inactive Publication Date: 2014-03-26
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
View PDF2 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0040] Take 100 grams of Baixue tea (purchased from Fuqintang, Guandu District, Kunming City, Yunnan Province), heat and reflux 3 times with 1.2 liters of absolute ethanol for 1 hour each time, filter, recover the ethanol, and obtain 14.3 grams of Baixuecha extract I powder.
[0041] Get 10 grams of white snow tea extract I and dissolve it in an appropriate amount of methanol, and through silica gel (200-300 mesh) column chromatography, CHCl 3 -CH 3 OH gradient elution gave flaky acid (compound 1, 460 mg) and choic acid (compound 2, 500 mg).
[0042] Squamatic acid (compound 1, squamatic acid): C 19 h 18 o 9 ; White powder, soluble in dimethyl sulfoxide, insoluble in methanol, ethanol. ESI-MS: m / z389.1[M-H] - ; 1 H NMR (C 5 D. 5 N,300MHz): δ7.02(1H,s,H-5′),6.55(1H,s,H-5),3.90(3H,s,OMe-4),2.81(3H,s,Me-8 '), 2.61 (3H, s, Me-8), 2.57 (3H, s, Me-9'); 13 C NMR (C 5 D. 5 N, 75MHz): 114.5(C-1), 166.9(C-2), 104.5(C-3), 162.4(C-4), 104.9(C-5), 144.0(C-6), 163.0(C -7), 21.2...
Embodiment 2
[0046] Take 100 grams of Baixue tea, heat and reflux twice with 1.0 liter of anhydrousmethanol, each time for 3 hours, filter, recover methanol, and obtain 12.4 grams of Baixue tea extract II powder. The content of capric acid in the obtained Bai Xue tea extract II is 19.2wt%, and the content of flaky acid is 19.1wt%.
Embodiment 3
[0048] Take 100 grams of Baixue tea, heat and reflux twice with 1.0 liter of 50% ethanol for 1 hour each time, filter, recover methanol, and obtain 5.3 grams of Baixue tea extract III powder. The content of capric acid in the obtained Bai Xue tea extract III is 3.0wt%, and the content of flaky acid is 2.6wt%.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention provides application of compounds or pharmaceutically acceptable salts shown as the general formula I, and application of pharmaceutical compositions and plant extract products both containing the compounds or the pharmaceutically acceptable salts. The compounds or pharmaceutically acceptable salts of the general formula I, the pharmaceutical compositions and the plant extract products are capable of increasing the transcription of lipoproteinlipase in adipocyte in cell level, thereby improving lipid metabolism. Therefore, the compounds or pharmaceutically acceptable salts of the general formula I, the pharmaceutical compositions and the plant extract products are applicable to prepare medicines for treating II type diabetes and hypertriglyceridemia.
Description
technical field [0001] The present invention relates to the use of a depsipepsic acid derivative shown in general formula I, in particular to a depsipsic acid derivative shown in general formula I and a composition containing the depsipsic acid derivative in the preparation of prevention or treatment with increased Use in medicine for diseases related to the transcription of lipoproteinlipase in adipocytes. Background technique [0002] Diabetes mellitus is mainly caused by a series of metabolic disorders of sugar, protein, fat, water and electrolytes caused by the absolute deficiency of insulinsecretion or the relative deficiency of insulinsecretion caused by the decreased sensitivity of target tissue cells to insulin. . At present, diabetes is generally divided into two types, type 1 diabetes and type 2 diabetes, and 90% of diabetes is type 2 diabetes. Type 2 diabetes also has strong genetic and environmental factors, and shows significant heterogeneity. The pathogene...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
