A kind of nano-hydroxyapatite and preparation method thereof
A technology of nano-hydroxyapatite and phosphate, which is applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of cumbersome preparation process, unsuitable for large-scale production, expensive raw materials, etc., and achieve simple preparation method, Controllable shape, mild and controllable conditions
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0020] A preparation method of nano-hydroxyapatite, comprising the steps of:
[0021] (1) Natural mulberry silk was degummed by boiling 0.05% sodium carbonate solution for 30 minutes, and obtained pure mulberry silk fibroin fiber after repeating 3 times; the silk fibroin fiber was dissolved in a mixed solution of formic acid / calcium chloride, wherein The mass ratio of silk fibroin fiber and calcium chloride is 1:0.5, and magnetically stirred at room temperature for 3 hours to obtain a regenerated silk fibroin solution with a mass fraction of 5%. The regenerated silk fibroin solution is formed into a film, dried, washed with water, and then dried. Obtain regenerated silk fibroin film;
[0022] (2) will (NH 4 ) 2 HPO 4 Prepared into 0.5mol / L (NH 4 ) 2 HPO 4 aqueous solution, and adjust the pH value of the solution to 11 with ammonia water; put the regenerated silk fibroin film into 0.5mol / L (NH 4 ) 2 HPO 4 In an aqueous solution, aging at room temperature for 3 hours, f...
Embodiment 2
[0025] (1) Natural mulberry silk was degummed by boiling with 0.05% sodium carbonate solution for 30 minutes, and obtained pure mulberry silk fibroin fiber after repeating 3 times; The mass ratio of fibroin fiber and calcium nitrate is 1:1, and magnetically stirred at room temperature for 3 hours to obtain a regenerated silk fibroin solution with a mass fraction of 20%. The regenerated silk fibroin solution is formed into a film, dried, washed with water, and then dried to obtain a regenerated silk fibroin solution. silk fibroin film;
[0026] (2) put H 3 PO 4 Prepared into 0.1mol / L H 3 PO 4 aqueous solution, and adjust the pH value of the solution to 7 with ammonia water; put the regenerated silk fibroin film into 0.1mol / L H 3 PO 4 In the aqueous solution, stand at room temperature for aging reaction for 120 hours, filter, wash with deionized water and absolute ethanol for 10 minutes, and then dry at 120° C. for 1 hour to obtain nano-hydroxyapatite materials.
Embodiment 3
[0028] (1) Natural tussah silk was degummed by boiling in a sodium carbonate solution with a mass fraction of 0.5% for 30 minutes, and obtained pure mulberry silk fibroin fiber after repeating 3 times; the silk fibroin fiber solution was dissolved in hexafluoroisopropanol / calcium chloride In the mixed solution, wherein the mass ratio of silk fibroin fiber and calcium chloride is 20:1, magnetically stir at room temperature for 6h, obtain a regenerated silk fibroin solution with a mass fraction of 0.2%, form a film of the regenerated silk fibroin solution, and dry, Washing with water and drying to obtain regenerated silk fibroin film;
[0029] (2) will (NH 4 ) 2 HPO 4 Prepared into 0.2mol / L (NH 4 ) 2 HPO 4 aqueous solution, and the pH value of the solution was adjusted to 6 with hydrochloric acid; the regenerated silk fibroin film was placed in 0.2mol / L (NH 4 ) 2 HPO 4 In the aqueous solution, stand at room temperature for aging reaction for 24 hours, filter, wash with d...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| width | aaaaa | aaaaa |
| pore size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More