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Electrodeposition preparation method of a photocrosslinked bio-based coating

An electrodeposition, bio-based technology, used in coatings, electrolytic coatings, medical science and other directions, can solve the problems of biomedical materials application limitations, poor mechanical properties, etc., and achieve good biodegradability and good biocompatibility. Effect

Active Publication Date: 2016-05-25
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although such biomedical materials have good biological activity, due to their poor mechanical properties, it is difficult to meet the requirements as implant materials, and their clinical application as biomedical materials is greatly limited.

Method used

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  • Electrodeposition preparation method of a photocrosslinked bio-based coating

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Experimental program
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Effect test

Embodiment 1

[0043] A preparation method for electrodeposition of a photocrosslinked bio-based coating, the specific preparation steps are as follows:

[0044] (1) Synthesis of photosensitive amphiphilic ionic bio-based macromolecules: To synthesize chitosan photosensitive amphiphilic ionic bio-based macromolecules, 0.161g of chitosan, 0.633g of cinnamic acid and 0.212g of 1-ethyl -(3-Dimethylaminopropyl)carbodiimide hydrochloride was dissolved in 20mL methanesulfonic acid, stirred and reacted at 0°C for 28h, after the reaction was completed, the final reaction solution was dialyzed through a cellulose membrane to remove unreacted catalyst and Small molecules, freeze-dried to obtain products;

[0045] (2) Preparation of the photosensitive amphiphilic ionic bio-based macromolecule solution: dissolve the photosensitive amphiphilic ionic bio-based macromolecule synthesized in step (1) in N,N-dimethylformamide at a concentration of 5mg / mL chitosan photosensitive amphipathic ionic bio-based ma...

Embodiment 2

[0051] A preparation method for electrodeposition of a photocrosslinked bio-based coating, the specific preparation steps are as follows:

[0052] (1) Synthesis of photosensitive amphiphilic ionic bio-based macromolecules: Synthesis of polyglutamic acid photosensitive amphiphilic ionic bio-based macromolecules, 0.659g of polyglutamic acid, 1.933g of 7-amino-4-methyl Coumarin, 0.671g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 0.5g of 4-dimethylaminopyridine were dissolved in 150mL of dimethyl sulfoxide, stirred at 25°C 20h, after the reaction is completed, the final reaction solution is dialyzed through a cellulose membrane to remove unreacted catalysts and small molecules, and freeze-dried to obtain the product;

[0053] (2) Preparation of the photosensitive amphiphilic ionic bio-based macromolecule solution: dissolve the photosensitive amphiphilic ionic bio-based macromolecule synthesized in step (1) in the good solvent dimethyl sulfoxide, and the conce...

Embodiment 3

[0059] A preparation method for electrodeposition of a photocrosslinked bio-based coating, the specific preparation steps are as follows:

[0060] (1) Synthesis of photosensitive amphiphilic ionic bio-based macromolecules: Dissolve 2g of hyaluronic acid in 100mL of solvent water, add 10g of 7-amino-4-methylcoumarin, initiator 7g of 1-ethyl-(3-di Methylaminopropyl) carbodiimide hydrochloride, 12g N-hydroxysuccinimide, stirred at 4°C for 24h. The reaction solution is dialyzed through a cellulose membrane to remove unreacted catalysts and small molecular monomers, and freeze-dried to obtain photosensitive amphiphilic ionic bio-based macromolecules.

[0061] (2) Preparation of the photosensitive amphiphilic ionic bio-based macromolecule solution: the photosensitive amphiphilic ionic bio-based macromolecule in step (1) was prepared in a good solvent water with a concentration of 3 mg / mL;

[0062] (3) Preparation of self-assembled micelles and composite self-assembled micelles coat...

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Abstract

The invention provides an electrodeposition preparation method of a light-crosslinking bio-based coating. The preparation method comprises the following steps: preparing micellar particles and compound self-assembly micelles particles of coating functional factors from amphiphilic ionic biological macromolecules containing photosensitive groups in a self-assembly manner; forming a film on a medical metal surface by using a potentiostatic electrodeposition technology; carrying out crosslinking on the micellar particles by ultraviolet irradiation crosslinking reaction, so as to obtain a medical biological coating material based on a self-assembly micellar film. The method is simple and convenient to operate, mild in condition and wide in application range.

Description

technical field [0001] The invention relates to the technical field of combining polymer materials and medical biological coatings, in particular to an electrodeposition preparation method of biological-based coatings. Background technique [0002] Since the beginning of this century, with the rapid development of science and technology and productivity, people's quality of life has been continuously improved and their life expectancy has been extended. How to improve the recovery efficiency of patients in medical treatment has attracted the attention of the medical community and material workers. The rapid development of biomedical materials provides the possibility to realize this requirement. On the other hand, my country, as the world's most populous country that is heading towards an aging population, has an increasing demand for biomedical materials. [0003] Among all biomedical materials, biomedical metal materials are widely used in clinical medicine due to their ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D15/00A61L31/10A61L31/16
Inventor 刘晓亚孙家娣孟龙魏玮罗静
Owner JIANGNAN UNIV
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