Flurbiprofen double-layer osmotic pump controlled-release tablet and preparation method thereof

A technology of osmotic pump controlled release and flurbiprofen, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery. problems such as large fluctuations

Active Publication Date: 2014-05-28
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary oral preparations are frequently taken, with large fluctuations in blood drug concentration, large side effects such as gastrointestinal reactions, and high patient compliance, which is not conducive to clinical treatment

Method used

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  • Flurbiprofen double-layer osmotic pump controlled-release tablet and preparation method thereof
  • Flurbiprofen double-layer osmotic pump controlled-release tablet and preparation method thereof
  • Flurbiprofen double-layer osmotic pump controlled-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Tablet prescription:

[0025] Drug-containing layer:

[0026] Flurbiprofen 200mg

[0027] Polyoxyethylene 100mg

[0028] Sodium chloride 45mg

[0029] Mannitol 45mg

[0030] Magnesium Stearate 4mg

[0031] Boost layer:

[0032] Polyoxyethylene 200mg

[0033] Sodium chloride 50mg

[0034] Semi-permeable membrane envelope prescription:

[0035] Cellulose acetate 15mg

[0036] Polyethylene glycol 1.5mg

[0037] Solution prescription for dissolving coating material:

[0038] Acetone 500ml

[0039] Distilled water 15ml

[0040] Preparation Process:

[0041] Pass the prescribed amount of medicine, polyoxyethylene with a molecular weight of 200,000, sodium chloride, mannitol, and magnesium stearate through an 80-mesh sieve, and mix evenly; pass the prescribed amount of polyoxyethylene and sodium chloride with a molecular weight of 4,000,000 80-mesh sieve, mix evenly, use No. 12 punch twice to pressurize to get the tablet core. Dissolve cellulose acetate and poly...

Embodiment 2

[0043] Tablet prescription:

[0044] Drug-containing layer:

[0045] Flurbiprofen 200mg

[0046]Polyvinylpyrrolidone 150mg

[0047] Mannitol 50mg

[0048] Magnesium Stearate 4mg

[0049] Boost layer:

[0050] Polyoxyethylene 150mg

[0051] Sodium chloride 50mg

[0052] Semi-permeable membrane envelope prescription:

[0053] Cellulose acetate 15mg

[0054] Polyethylene glycol 3mg

[0055] Solution prescription for dissolving coating material:

[0056] Acetone 500ml

[0057] Distilled water 15ml

[0058] Preparation Process:

[0059] Pass the prescribed amount of medicine, polyvinylpyrrolidone, mannitol, and magnesium stearate through a 80-mesh sieve, and mix evenly; pass the prescribed amount of polyoxyethylene and sodium chloride with a molecular weight of 7,000,000 through an 80-mesh sieve, mix evenly, and use Press the No. 12 punch twice to get the tablet core. Dissolve cellulose acetate and polyethylene glycol with an average molecular weight of 2000 in aceton...

Embodiment 3

[0061] Tablet prescription:

[0062] Drug-containing layer:

[0063] Flurbiprofen 200mg

[0064] Sodium Alginate 200mg

[0065] Mannitol 50mg

[0066] Micronized silica gel 5mg

[0067] Magnesium Stearate 4mg

[0068] Boost layer:

[0069] Polyoxyethylene 150mg

[0070] Sodium chloride 50mg

[0071] Semi-permeable membrane envelope prescription:

[0072] Cellulose acetate 15mg

[0073] Polyethylene glycol 1mg

[0074] Solution prescription for dissolving coating material:

[0075] Acetone 500ml

[0076] Distilled water 10ml

[0077] Preparation Process:

[0078] Pass the prescribed amount of medicine, sodium alginate, mannitol, micropowder silica gel, and magnesium stearate through an 80-mesh sieve, and mix evenly; pass the prescribed amount of polyoxyethylene and sodium chloride with a molecular weight of 7,000,000 through an 80-mesh sieve, and mix Evenly, use the No. 12 punch to press twice to get the tablet core. Dissolve cellulose acetate and polyethylene gl...

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Abstract

The invention belongs to the technical field of pharmaceutic preparations, and discloses a flurbiprofen double-layer osmotic pump controlled-release tablet and a preparation method thereof. The flurbiprofen double-layer osmotic pump controlled-release tablet comprises flurbiprofen and a pharmaceutically acceptable polymer, and consists of a tablet core and a controlled-release coat coating the tablet core and having medicine-releasing holes, wherein a medicine layer comprises 200mg of flurbiprofen, 10-90mg of osmotic active substance, 100-300mg of suspension and 3-10mg of lubricant; a boosting layer comprises 100-200mg of sweller and 10-50mg of osmotic active substance; a semipermeable coat comprises 10-20g of semipermeable high molecular material, 0.5-3g of water-soluble pore-foaming agent and a proper amount of an organic solvent; the weight of the coat is 6-12% that of the tablet core; 1-2 medicine-releasing holes are drilled in one side of the medicine layer of the coated tablet by using laser or a mechanical drill. The flurbiprofen double-layer osmotic pump controlled-release tablet can effectively adjust constant-speed medicine release to obtain steady blood concentration, thereby reducing the medicine taking times and improving patient compliance, and has the characteristics of few medicine taking times, convenience in taking, lasting effect and stable therapeutic effect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to flurbiprofen double-layer osmotic pump controlled-release tablets and a preparation method thereof. Background technique [0002] Flurbiprofen (Flurbiprofen) is a new type of non-steroidal anti-inflammatory analgesic with high potency and low toxicity, and its chemical name is (±)-2-(2-fluoro-4-biphenyl)-propionic acid. For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, soft tissue diseases such as sprains and strains, and mild to moderate pain such as dysmenorrhea and postoperative pain, toothache, trauma pain and other pain . [0003] Flurbiprofen acts as an anti-inflammatory and analgesic by inhibiting the activity of prostaglandin synthase cyclooxygenase. Flurbiprofen introduces a fluorine atom into the molecular structure. The unique properties caused by the fluorine atom make it have a stronger effect among similar drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K9/32A61K9/36A61K9/44A61K31/192A61P29/00
Inventor 潘卫三彭俊杰刘韵潘昊
Owner SHENYANG PHARMA UNIVERSITY
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