Method for preparing gelatin/nano-silver/chitosan derivative composite film

A technology of chitosan derivatives and composite films, applied in the interdisciplinary field of polymer chemistry and biochemistry, and in the field of biomaterials, to achieve good sterilization, low price, and good biocompatibility

Inactive Publication Date: 2014-06-04
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the application of gelatin in the field of biomacromolecular materials is mainly limited to surface coating agents, fillers or crosslinking agents, etc., and gelatin is used as the main raw material to prepare nano-silver by in situ reduction and will be applied to the research and application of self-assembled thin films. rarely reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of gelatin aqueous solution: Take 4g of gelatin particles in a beaker, add 30mL of deionized water into the beaker, stir and heat up to 70°C and keep it warm for 1 hour to prepare a gelatin aqueous solution with a mass concentration of 11.8%.

[0031] (2) Preparation of gelatin / nano-silver sol: Pour 30mL of the gelatin aqueous solution prepared in step (1) into a 50mL three-necked flask, add 0.5g silver nitrate powder into the three-necked flask, heat up to 95°C and keep stirring for 1 hour .

[0032] (3) Preparation of gelatin / nano-silver film: immerse the quartz plate in a mixed solution of concentrated sulfuric acid and hydrogen peroxide with a volume ratio of 7:3, after 3 hours, take it out and rinse it with deionized water; then immerse it in step (2) The gelatin / nano-silver sol prepared at 65°C for 1 hour, took out and blotted the excess gelatin / nano-silver sol on the surface, and cooled at room temperature for 10 minutes.

[0033] (4) Preparation...

Embodiment 2

[0035] (1) Preparation of gelatin aqueous solution: Take 8 g of gelatin particles in a beaker, add 32 mL of deionized water into the beaker, stir and heat up to 80 °C and keep it warm for 1 hour to prepare a gelatin aqueous solution with a mass concentration of 20%.

[0036] (2) Preparation of gelatin / nano-silver sol: Pour 30mL of the gelatin aqueous solution prepared in step (1) into a 50mL three-necked flask, add 0.6g of silver nitrate powder into the three-necked flask, heat up to 95°C and keep stirring for 1 hour .

[0037] (3) Preparation of gelatin / nano-silver film: immerse the quartz plate in a mixed solution of concentrated sulfuric acid and hydrogen peroxide with a volume ratio of 7:3, after 3 hours, take it out and rinse it with deionized water; then immerse it in step (2) The gelatin / nano-silver sol prepared at 60°C for 2 hours, took out and blotted the excess gelatin / nano-silver sol on the surface, and cooled and stood at room temperature for 20 minutes.

[0038] ...

Embodiment 3

[0040] (1) Preparation of gelatin aqueous solution: Take 4 g of gelatin granules in a beaker, add 60 mL of deionized water into the beaker, stir and heat up to 65 °C and keep it warm for 2 hours to prepare a gelatin aqueous solution with a mass concentration of 6.25%.

[0041] (2) Preparation of gelatin / nano-silver sol: Pour 30mL of the gelatin aqueous solution prepared in step (1) into a 50mL three-necked flask, add 0.1g of silver nitrate powder into the three-necked flask, heat up to 90°C and keep stirring for 1 hour .

[0042] (3) Preparation of gelatin / nano-silver film: immerse the quartz plate in a mixed solution of concentrated sulfuric acid and hydrogen peroxide with a volume ratio of 7:3, after 3 hours, take it out and rinse it with deionized water; then immerse it in step (2) The gelatin / nano-silver sol prepared at 60°C for 3 hours, took out and blotted the excess gelatin / nano-silver sol on the surface, and cooled and stood at room temperature for 15 minutes.

[0043...

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PUM

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Abstract

The invention provides a method for preparing a gelatin/nano-silver/chitosan derivative composite film. The composite film is prepared by the following steps: by taking gelatin as a main raw material, heating to raise the temperature for dissolving gelatin particles, preparing gelatin/nano-silver sol through an in-situ reduction method, and preparing a gelatin/nano-silver film by adopting a self-assembling method in the solution; assembling a chitosan derivative macromolecule on the surface of the gelatin/nano-silver film by further adopting an electrostatic self-assembling method, and thus preparing the gelatin/nano-silver/chitosan derivative antibacterial composite film. The composite film has high biocompatibility and high antibacterial and bactericidal performance and is environment-friendly. Moreover, because the main raw material is gelatin, the composite film is rich in source, low in price, and good in film-forming property and has wide application prospects in aspects such as human skin, medical antibiosis and hemostatic materials. Meanwhile, the composite film is simple in preparation process and low in equipment requirement.

Description

technical field [0001] The invention belongs to the interdisciplinary fields of biological materials, polymer chemistry and biochemistry, and discloses a preparation method of a gelatin / nanometer silver antibacterial composite film modified by chitosan derivatives. Background technique [0002] As an extract of animal collagen tissue, gelatin is a natural macromolecule and biomacromolecular material, which has good biocompatibility, non-antigenicity, hemostasis, and promotion of tissue healing. my country's gelatin resources are rich in reserves, wide in sources, and low in price. Due to gelatin's good reactivity, film-forming properties, coagulation properties, biocompatibility, degradability, green environmental protection and renewable properties, it has become a popular resource in recent years. To become a research hotspot in the field of biomacromolecular materials science. At present, the application of gelatin in the field of biomacromolecular materials is mainly lim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L89/00C08L5/08C08K3/08A61L27/40A61L27/60A61L27/54A61L15/32A61L15/28A61L15/44
Inventor 李立东夏碧华
Owner UNIV OF SCI & TECH BEIJING
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