Freeze-dried preparation for treating gynecological diseases as well as preparation method and application thereof

A technology of gynecological diseases and freeze-dried preparations, which is applied in the medical field, can solve the problems of lack of gynecological diseases, long-term cure, and female diseases, and achieve the effect of strong antibacterial and anti-inflammatory effects

Inactive Publication Date: 2014-07-16
舒泰经贸(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Because many people lack proper understanding of gynecological diseases, lack of health care for the body, and various bad living habits, etc., the physical health is deteriorating, causing some women to suffer from diseases that cannot be cured for a long time, which brings great harm to normal life and work. big inconvenience

Method used

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  • Freeze-dried preparation for treating gynecological diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Freeze-dried powder of the present invention is configured as:

[0031] Weigh 10g of human beta defensin and 600g stabilizer, add 10000ml of injection grade water, mix well, filter and sterilize, fill in 3.2ml in a vial with a half stopper and put it into a vacuum freeze dryer for 15 hours to freeze dry.

[0032] The process conditions of vacuum freeze-drying are as follows: pre-freeze the product, lower the temperature to -50°C, cool down for 4 hours, evacuate to 0.3mbar, heat and sublimate and dry for 15 hours, until the water in the product is completely sublimated .

[0033] Wherein the stabilizer formula is: 200g glycine, 300g protein hydrolyzate, 100g (10mM) phosphoric acid.

[0034] The configuration of basic liquid in the present embodiment is:

[0035] Basic liquid formula:

[0036] Hyaluronic Acid 21.22g

[0037] Methylpropanediol 106.1g

[0038] Honey Extract 318.3g

[0039] Sodium PCA 159.15g

[0040] Dissolved Protease 265.25g

[0041] 1,2 hexanedio...

Embodiment 2

[0047] Freeze-dried powder of the present invention is configured as:

[0048] Weigh 50g of human beta defensin and 650g of stabilizer, add 10000ml of injection grade water, mix well, filter and sterilize, fill in 3.2ml in a vial with a half-stopper and put it into a vacuum freeze dryer for 25 hours to freeze-dry.

[0049] The process conditions of vacuum freeze-drying are: pre-freeze the product, lower the temperature to -50°C, cool down for 6 hours, vacuumize to 0.3mbar, heat and sublimate and dry for 20 hours, until the water in the product sublimates completely .

[0050] Wherein the stabilizer formula is: 200g trehalose, 300g sodium thiosulfate, 150g (15mM) sodium carbonate.

[0051] The configuration of basic liquid in the present embodiment is:

[0052] Basic liquid formula:

[0053] Hyaluronic Acid 26.75g

[0054] Honey Extract 214g

[0055] Sodium PCA 321g

[0056] Dissolving Protease 321g

[0057] 1,2 hexanediol 53.5g

[0058] Oat Beta Glucan 214g

[0059] ...

Embodiment 3

[0063] The freeze-dried powder is configured as follows: 100g human beta defensin, 600g stabilizer, add 10000ml injection grade water, mix evenly, filter and sterilize, fill in 3.2ml vials and half-stopper them, then put them into a vacuum freeze dryer to freeze-dry 35h. The process conditions of vacuum freeze-drying are: pre-freeze the product, lower the temperature to -50°C, cool down for 8 hours, vacuumize to 0.3mbar, heat and sublimate and dry for 25 hours, until the water in the product sublimates completely .

[0064] Wherein the stabilizer formula is: 200g sucrose, 300g vitamin D, 100g (10mM) potassium citrate.

[0065] The configuration of basic liquid in the present embodiment is:

[0066] Basic liquid formula:

[0067] Hyaluronic Acid 32.1g

[0068] Methylpropanediol 267.5g

[0069] Honey Extract 374.5g

[0070] Sodium PCA 214g

[0071] Dissolving Protease 321g

[0072] Oat Beta Glucan 374.5g

[0073] Soy Isoflavones 428g

[0074] Deionized water 10000ml. ...

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Abstract

The invention provides a freeze-dried preparation for treating gynecological diseases as well as a preparation method and an application thereof. The freeze-dried preparation for treating gynecological diseases includes gynecological disease treating freeze-dried powder and a gynecological disease treating basic solution, wherein the freeze-dried powder consists of the following components in percentage by mass: 0.1-8% of human beta-defensin and 1-15% of a stabilizer; the basic solution consists of the following components in percentage by mass: 0.01-0.4% of hyaluronic acid, 0.5-4% of methyl propanediol, 0.5-5% of a honey extract, 0.5-5% of PCA sodium, 0.5-5% of dissolved protease, 0.3-0.7% of 1,2-hexanediol, 1.5-6% of oat beta-glucan, 1-5% of soy isoflavone and the balance of de-ionized water or injection water. The freeze-dried preparation for treating gynecological diseases disclosed by the invention is suitable for sterilizing, diminishing inflammation, and treating such gynecological diseases as trichomoniasis, vaginal itching and swelling, fungus, gonococcus, bacterial cervicitis, chronic cervicitis, cervical erosion, papillary hyperplasia, pelvic inflammation and endometritis.

Description

technical field [0001] The invention relates to the medical field, in particular to a freeze-dried preparation for treating gynecological diseases, a preparation method and application thereof. Background technique [0002] Because many people lack proper understanding of gynecological diseases, lack of health care for the body, and various bad living habits, etc., the physical health is deteriorating, causing some women to suffer from diseases that cannot be cured for a long time, which brings great harm to normal life and work. Big inconvenience. Trichomoniasis, vulva itching and swelling, fungi, gonorrhea, bacterial cervicitis, chronic cervicitis, cervical erosion, papillary hyperplasia, pelvic inflammatory disease, endometritis, etc. are common gynecological diseases. At present, the extensive application of various traditional antibiotics in the treatment of gynecological diseases has brought a variety of drug-resistant microorganisms to women, and drug-resistant micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/19A61P31/04A61P29/00A61P33/02A61P31/10A61P15/00
Inventor 张晏万宇黄小妹陈凡
Owner 舒泰经贸(广州)有限公司
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