Method for preparing triiron tetraoxide nanometer particles

Abstract

The invention discloses a method for preparing triiron tetraoxide nanometer particles. A hyperbranched polymer is hydrophobically modified by fatty acyl chloride to prepare an amphiphilic hyperbranched polymer; and the highly dispersed triiron tetraoxide nanometer particles are prepared via a water / organic one-step solvothermal method by virtue of the micelle self-assembly effect of the amphiphilic hyperbranched polymer as a protective agent in a solution, the average particle size of the triiron tetraoxide nanometer particles is 8nm-35nm; the surfaces of the triiron tetraoxide nanometer particles are amphiphilically modified by virtue of encapsulation and dispersion effects of the amphiphilic hyperbranched polymer on the triiron tetraoxide nanometer particles, so that triiron tetraoxide nanometer particles are dispersed and stably exist in solvents with different degrees of polarity, at the same time, a plurality of active groups are given on the surface of the particles, the active groups provide possible sites for the secondary functionalization of particles and the application range of the triiron tetraoxide nanometer particles is extended.

Description

technical field

[0001] The invention relates to a method for preparing iron ferric oxide nanoparticles, belonging to the field of nanometer materials. Background technique

[0002] Magnetic nanoparticles refer to magnetic particles with a particle size between 1 and 100 nm. They are new functional materials that combine nanomaterials and magnetic materials. performance and become the focus of attention. Like other nanometer-sized materials, magnetic nanoparticles have the quantum size effect, small size effect, and surface effect of nanoparticles, and at the same time have the unique superparamagnetism of magnetic nanoparticles. These properties and characteristics determine that it has broad application prospects in the fields of hyperthermia treatment of tumors, targeted drug carriers, sewage treatment, catalyst carriers, cell separation, biosensors, and magnetic recording materials.

[0003] There are many kinds of magnetic nanoparticles, and Fe3O4 nanoparticles have gr...

Examples

Embodiment 1

[0027] Dissolve 6.0 mL of oleoyl chloride in 60 mL of toluene, and dissolve 2 g of hyperbranched polyglycidyl ether in 80 mL of pyridine. The obtained oleoyl chloride toluene solution is dropped dropwise into the pyridine solution of hyperbranched polyglycidyl ether. After stirring at 30°C for 48 hours, The excess solvent was removed by rotary evaporation at 80°C, and the excess oleoyl chloride was removed by washing with chloroform to obtain amphiphilic hyperbranched polyglycidyl ether.

[0028] Take (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O 0.784g was dissolved in 20mL deionized water, 0.5g amphiphilic hyperbranched polyglycidyl ether was dissolved in 10mL chloroform, and under rapid stirring, the amphiphilic hyperbranched polyglycidyl ether solution was slowly added dropwise to (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 1g NaOH was dissolved in 10mL ethanol, and the resulting NaOH solution was added dropwise to the above Fe 2...

Embodiment 2

[0035] Take 1.0 mL of oleoyl chloride and dissolve in 80 mL of toluene, and dissolve 1 g of amino-terminated hyperbranched polymer in 100 mL of pyridine. The obtained oleoyl chloride toluene solution is dropped dropwise into the pyridine solution of amino-terminated hyperbranched polymer, and after stirring at 25 ° C for 40 h, The excess solvent was removed by rotary evaporation at 80°C, and the excess oleoyl chloride was removed by washing with acetone to obtain an amphiphilic amino-terminated hyperbranched polymer.

[0036] FeSO 4 ·7H 2 O 1.112g was dissolved in 40mL deionized water, 1g amphiphilic amino-terminated hyperbranched polymer was dissolved in 20mL ethanol, and under rapid stirring, the amphiphilic amino-terminated hyperbranched polymer solution was slowly added dropwise to FeSO 4 ·7H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 2g KOH was dissolved in 20mL n-butanol, and the resulting KOH solution was added dropwise to the above Fe 2+ In...

Embodiment 3

[0038] Dissolve 5.0 mL of oleoyl chloride in 40 mL of diethyl ether, and dissolve 2 g of hyperbranched polyglycidyl ether in 50 mL of methanol. The obtained oleoyl chloride diethyl ether solution is dropped dropwise into the methanol solution of hyperbranched polyglycidyl ether. After stirring at 50°C for 56 hours, Rotary evaporation at 50°C removes excess solvent, washes with ethyl acetate to remove excess oleoyl chloride, and vacuum-dries at 60°C for 12 hours to obtain amphiphilic hyperbranched polyglycidyl ether.

[0039] FeCl 2 4H 2 O 0.3976g was dissolved in 20mL deionized water, 0.5g amphiphilic hyperbranched polyglycidyl ether was dissolved in 10mL ethylene glycol, and under rapid stirring, the amphiphilic hyperbranched polyglycidyl ether solution was slowly added dropwise to FeCl 2 4H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 15mL concentration of 28% ammonia solution was added dropwise to the above Fe 2+ In the precursor solution, the obt...

technical field

[0001] The invention relates to a method for preparing iron ferric oxide nanoparticles, belonging to the field of nanometer materials. Background technique

[0002] Magnetic nanoparticles refer to magnetic particles with a particle size between 1 and 100 nm. They are new functional materials that combine nanomaterials and magnetic materials. performance and become the focus of attention. Like other nanometer-sized materials, magnetic nanoparticles have the quantum size effect, small size effect, and surface effect of nanoparticles, and at the same time have the unique superparamagnetism of magnetic nanoparticles. These properties and characteristics determine that it has broad application prospects in the fields of hyperthermia treatment of tumors, targeted drug carriers, sewage treatment, catalyst carriers, cell separation, biosensors, and magnetic recording materials.

[0003] There are many kinds of magnetic nanoparticles, and Fe3O4 nanoparticles have gr...

Examples

Embodiment 1

[0027] Dissolve 6.0 mL of oleoyl chloride in 60 mL of toluene, and dissolve 2 g of hyperbranched polyglycidyl ether in 80 mL of pyridine. The obtained oleoyl chloride toluene solution is dropped dropwise into the pyridine solution of hyperbranched polyglycidyl ether. After stirring at 30°C for 48 hours, The excess solvent was removed by rotary evaporation at 80°C, and the excess oleoyl chloride was removed by washing with chloroform to obtain amphiphilic hyperbranched polyglycidyl ether.

[0028] Take (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O 0.784g was dissolved in 20mL deionized water, 0.5g amphiphilic hyperbranched polyglycidyl ether was dissolved in 10mL chloroform, and under rapid stirring, the amphiphilic hyperbranched polyglycidyl ether solution was slowly added dropwise to (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 1g NaOH was dissolved in 10mL ethanol, and the resulting NaOH solution was added dropwise to the above Fe 2...

Embodiment 2

[0035] Take 1.0 mL of oleoyl chloride and dissolve in 80 mL of toluene, and dissolve 1 g of amino-terminated hyperbranched polymer in 100 mL of pyridine. The obtained oleoyl chloride toluene solution is dropped dropwise into the pyridine solution of amino-terminated hyperbranched polymer, and after stirring at 25 ° C for 40 h, The excess solvent was removed by rotary evaporation at 80°C, and the excess oleoyl chloride was removed by washing with acetone to obtain an amphiphilic amino-terminated hyperbranched polymer.

[0036] FeSO 4 ·7H 2 O 1.112g was dissolved in 40mL deionized water, 1g amphiphilic amino-terminated hyperbranched polymer was dissolved in 20mL ethanol, and under rapid stirring, the amphiphilic amino-terminated hyperbranched polymer solution was slowly added dropwise to FeSO 4 ·7H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 2g KOH was dissolved in 20mL n-butanol, and the resulting KOH solution was added dropwise to the above Fe 2+ In...

Embodiment 3

[0038] Dissolve 5.0 mL of oleoyl chloride in 40 mL of diethyl ether, and dissolve 2 g of hyperbranched polyglycidyl ether in 50 mL of methanol. The obtained oleoyl chloride diethyl ether solution is dropped dropwise into the methanol solution of hyperbranched polyglycidyl ether. After stirring at 50°C for 56 hours, Rotary evaporation at 50°C removes excess solvent, washes with ethyl acetate to remove excess oleoyl chloride, and vacuum-dries at 60°C for 12 hours to obtain amphiphilic hyperbranched polyglycidyl ether.

[0039] FeCl 2 4H 2 O 0.3976g was dissolved in 20mL deionized water, 0.5g amphiphilic hyperbranched polyglycidyl ether was dissolved in 10mL ethylene glycol, and under rapid stirring, the amphiphilic hyperbranched polyglycidyl ether solution was slowly added dropwise to FeCl 2 4H 2 O aqueous solution, mixed evenly to get Fe 2+ Precursor solution; 15mL concentration of 28% ammonia solution was added dropwise to the above Fe 2+ In the precursor solution, the obt...

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