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A click chemically modified chitosan material suitable for 3D printing and its preparation method

A 3D printing and click chemistry technology, which is applied in the field of 3D printing materials and their preparation, can solve problems such as difficult to meet the mechanical strength of bone materials, and achieve the effects of controllable pore size distribution, improved performance, and high porosity

Active Publication Date: 2016-02-24
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Using chitosan alone as a 3D printing material is generally difficult to meet the mechanical strength required by bone materials

Method used

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  • A click chemically modified chitosan material suitable for 3D printing and its preparation method
  • A click chemically modified chitosan material suitable for 3D printing and its preparation method
  • A click chemically modified chitosan material suitable for 3D printing and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation method that the present invention applies:

[0050] 1. Add 2 parts by weight of 7% hydrogen bromide dropwise to 4 parts by weight of mPEG-1000, react at 10°C for 1 hour after the addition is completed, add an appropriate amount of xylene, heat up and reflux, and use a water separator to divide water at the same time, reduce Distill xylene under pressure, wash with acetone twice after cooling, and dry to obtain brominated polyethylene glycol mPEG-Br.

[0051] 2. Dissolve 1 part by weight of sodium azide in an appropriate amount of distilled water, then add the brominated polyethylene glycol obtained in step 1, react at 75°C for 21 hours, cool to 0°C, add appropriate amount of ether and potassium hydroxide, and separate The organic phase and the aqueous phase were extracted three times with excess ether, and the organic phases were combined. After drying overnight with anhydrous magnesium sulfate, it was filtered, and the diethyl ether was removed by rota...

Embodiment 2

[0063] The preparation method that the present invention applies:

[0064] 1. Add 5 parts by weight of 7% hydrogen bromide dropwise to 8 parts by weight of mPEG-2000, react at 10°C for 1 hour after the addition is completed, add an appropriate amount of xylene, heat up and reflux, and use a water separator to separate water at the same time, reduce Distill xylene under pressure, wash with acetone twice after cooling, and dry to obtain brominated polyethylene glycol mPEG-Br.

[0065] 2. Dissolve 2 parts by weight of sodium azide in an appropriate amount of distilled water, then add the brominated polyethylene glycol obtained in step 1, react at 75°C for 21 hours, cool to 0°C, add appropriate amount of ether and potassium hydroxide, and separate The organic phase and the aqueous phase were extracted three times with excess ether, and the organic phases were combined. After drying overnight with anhydrous magnesium sulfate, it was filtered, and the diethyl ether was removed by r...

Embodiment 3

[0074] Embodiment 3: As the optimization of the above-mentioned embodiments, polylactic acid-modified chitosan porous materials were prepared, and the raw materials included high-molecular-weight chitosan, polylactic acid with a low degree of polymerization, sodium azide, hydrogen bromide and propyne bromide.

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Abstract

The invention discloses a click chemistry modified chitosan material suitable for 3D printing. A chitosan combination comprises the raw material components by weight: 85-95 parts of a chitosan polymer, 2-8 parts of a low-polymerization-degree graft, 0.5-2 parts of an azidation reagent, 0.5-2 parts of an ethinylation reagent, and 2-5 parts of a halogenation reagent. The porous material formed by the chitosan combination and a printing method has the advantages of larger porosity, controllable pore size distribution, and certain strength; and a reaction of a modification process is mild and efficient.

Description

technical field [0001] The invention relates to a 3D printing material and a preparation method thereof, in particular to a 3D printing click chemically modified chitosan material and a preparation method thereof. Background technique [0002] 3D printing is a popular term for additive manufacturing technology. Generally, it refers to using a digital model to simulate a three-dimensional entity, using powdered metal or plastic and other bondable materials, and controlling the printing nozzle through a computer, which can control the outline of the entity layer by layer. It does not require traditional tools, fixtures and multiple processing procedures, and uses 3D design data to automatically, quickly and accurately manufacture parts of any complex shape under program control on one device, thereby realizing digital "free manufacturing" of design and manufacturing . This technology can realize the forming of many complex structural parts that were difficult to manufacture ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L87/00C08B37/08C08G81/00B29C67/00
Inventor 李志波王小实夏爽盛力符文鑫林学春马永梅孙文华徐坚董金勇李春成
Owner INST OF CHEM CHINESE ACAD OF SCI
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