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Gadolinium-doped zinc oxide nanoparticles and preparation method thereof

A technology of zinc oxide nanoparticles and particles, which is applied in the field of gadolinium-doped zinc oxide nanoparticles and its preparation, can solve the problem that the sensitivity is not as good as that of fluorescence imaging, and achieve the effects of simple operation, reduced product cost, and reduced biological toxicity

Inactive Publication Date: 2014-08-20
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Magnetic resonance imaging can image deep tissue, but is less sensitive than fluorescence imaging

Method used

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  • Gadolinium-doped zinc oxide nanoparticles and preparation method thereof
  • Gadolinium-doped zinc oxide nanoparticles and preparation method thereof
  • Gadolinium-doped zinc oxide nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve zinc methacrylate and gadolinium compounds in 100 ml of ethanol, and heat slightly to obtain a colorless and transparent solution, in which the concentration of zinc salt is about 0.1 mol / L; the molar ratio of gadolinium to zinc is 0.04. Add 0.3 g of azobisisobutyronitrile (AIBN) and 15 ml of methacrylic acid-monomethyl polyethylene glycol to the zinc methacrylate solution, heat and react together, the reaction temperature is 80 ° C, stir for 5 minutes Then add 0.3 g of azobisisobutyronitrile (AIBN) and 100 ml of 0.15 mol / L lithium hydroxide solution. The mixture was refluxed for 1 hour under the condition of heating and stirring, and purified by dialysis with deionized water to finally obtain an aqueous solution product.

Embodiment 2， Embodiment 3， Embodiment 4

[0021] Repeat Example 1, but the alkali solution is adjusted to sodium hydroxide, potassium hydroxide and calcium hydroxide respectively.

Embodiment 5

[0023] Dissolve zinc methacrylate and gadolinium compounds in 100 ml of ethanol, and heat slightly to obtain a colorless and transparent solution, in which the concentration of zinc salt is about 0.1 mol / L; the molar ratio of gadolinium to zinc is 0.08. Add 0.3 g of azobisisobutyronitrile (AIBN) and 15 ml of methacrylic acid-monomethyl polyethylene glycol to the mixed solution of zinc methacrylate and gadolinium, and heat the reaction together, the reaction temperature is 80°C After stirring for 5 minutes, add 0.3 g of azobisisobutyronitrile (AIBN) and 100 ml of 0.15 mol / L lithium hydroxide solution. The mixture was refluxed for 1 hour under the condition of heating and stirring, and purified by dialysis with deionized water to finally obtain an aqueous solution product.

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Abstract

The invention relates to gadolinium-doped zinc oxide nanoparticles and a preparation method thereof. The preparation method comprises the following steps: dissolving zinc methacrylate and a gadolinium compound in a solvent, heating to obtain a colorless transparent solution, adding 0.3g of azodiisobutyronitrile and 15ml of methacrylic acid-monomethyl polyethylene glycol ester, heating, stirring for 5 minutes, and adding 0.3g of azodiisobutyronitrile and 100ml of a 0.15mol / L alkali solution; performing reflux on a mixture under the conditions of heating and stirring for 1 hour, and dialyzing and purifying in de-ionized water to finally obtain a water solution product. The method has the advantages that cheap zinc materials with good biocompatibility are adopted, a gadolinium-doped zinc oxide nanoparticle product is directly synthesized by adopting a sol-gel method, the biological toxicity of the final product is reduced, the product cost is lowered, and the product has application prospect of magnetic resonance and fluorescent bifunctional imaging.

Description

technical field [0001] The invention relates to a zinc oxide nanoparticle and a preparation method thereof, in particular to a gadolinium-doped zinc oxide nanoparticle and a preparation method thereof. Background technique [0002] With the needs of biomedical research and diagnosis, the technology of bioimaging using nanomaterials has attracted more and more attention. Bioimaging techniques mainly include optical imaging, nuclear magnetic resonance imaging, ultrasound imaging and positron imaging. Since multifunctional imaging can provide more research and diagnostic information, a large number of researchers have invested in the preparation of multifunctional materials. [0003] The current fluorescence imaging (Fluorescence Imaging, FI) mainly uses organic fluorescent dyes or inorganic fluorescent nanomaterials for contrast imaging, which has the advantages of high sensitivity and short detection time. Traditional organic fluorescent dyes are prone to photobleaching and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/54
Inventor 何丹农张华娟程杰军朱君周涓许建荣
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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