Patella tissue engineering scaffold and its manufacturing material and preparation method

Abstract

A scaffold for patellar tissue engineering, wherein the scaffold is formed of magnesium, aluminum, zinc and zirconium, wherein the mass ratio of magnesium, aluminum, zinc and zirconium is: 85-95:0-6:0-4:0-4; The shape of the stent is consistent with that of the human patella, and the stent is formed by interweaving trabeculae, and a plurality of holes are formed between the trabeculae. The diameter of the holes is 0.1-0.8 mm, and the porosity of the holes is 30. ~80%. The above-mentioned support has the same shape as the human patella, and can be well matched with the patellofemoral articular surface of the human body or the artificial knee joint, which can reduce the wear of the patella tissue engineering support, thereby reducing the generation of wear debris, and the above-mentioned support The above-mentioned material is used, so the above-mentioned bracket can be degraded in the human body, and metal ions beneficial to the human body, such as magnesium ions, are produced after degradation. Therefore, the above-mentioned bracket does not produce wear debris that is harmful to the human body. In addition, a material for manufacturing the above bracket and a preparation method of the above bracket are also provided.

Description

【Technical field】 [0001] The invention relates to the technical field of biomedical tissue engineering, in particular to a material for manufacturing a patella tissue engineering support, a patella tissue engineering support and a preparation method thereof. 【Background technique】 [0002] Patella softening is the degenerative change of the articular cartilage of the patella due to damage, including swelling, fragmentation, detachment and corrosion of the cartilage surface of the patella. An effective treatment for patella softening is patellar replacement surgery. In the existing patella conversion surgery, the patella shell prosthesis is generally used for patella surface replacement. [0003] The material of the patella shell prosthesis is generally non-degradable materials such as polyethylene, and the common patella shell prosthesis includes anatomical type and dome cap type. The contact stress between the anatomical patellar shell prosthesis and the femoral component...

AI Technical Summary

Problems solved by technology

[0004] Due to the low contact stress between the anatomical patella shell prosthesis and the femoral prosthesis, and the high shear stress with the patella, while the dome-shaped patella shell prosthesis is not consistent with the shape of the normal patella, the patellar shell installed in the human body Prosthetics are prone to wear and tear

The patella shell prosthesis is made of non-degradable materials such as polyethylene, and the wear debris formed during the wear process may cause synovitis and metallization, which is harmful to the human body

Images