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Preparation method of hydroxyapatite material doped with fluorine and potassium

A technology of potassium hydroxyapatite and calcium phosphate powder, which is applied in chemical instruments and methods, dental preparations, phosphorus compounds, etc., can solve the problems of large output and unreported research, achieve less impurities, simple preparation process, and enhanced The effect of medicine

Active Publication Date: 2014-10-01
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no method to prepare fluorine-doped potassium hydroxyapatite with high purity and large yield.
At present, most of the literature reports focus on the research on fluorine-doped hydroxyapatite, and there is no report on the preparation of fluorine-doped potassium hydroxyapatite.

Method used

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  • Preparation method of hydroxyapatite material doped with fluorine and potassium
  • Preparation method of hydroxyapatite material doped with fluorine and potassium
  • Preparation method of hydroxyapatite material doped with fluorine and potassium

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The preparation method of the present invention comprises the following steps:

[0040] 1) Press Ca(NO 3 ) 2 4H 2 O and H 3 PO 4 The molar ratio is 3:2 to weigh raw materials, Ca(NO 3 ) 2 4H 2 O was mixed with distilled water at a mass ratio of 1:10, and then H 3 PO 4 Mix with distilled water at a mass ratio of 1:45, and then add H 3 PO 4 Aqueous solution was added to Ca(NO 3 ) 2 The solution is mixed evenly to obtain a mixed solution, and the pH of the mixed solution is adjusted with NaOH solution so that the pH value of the mixed solution system is maintained at 8-10, and then the mixed solution is centrifuged, continuously washed, and suction filtered.

[0041] 2) Put the precipitate obtained in step 1) into a muffle furnace, heat and keep it at 200°C for 1 hour, take it out, grind it, then put it into a corundum crucible and raise the temperature to 1300°C at 10°C / min, and keep it warm for 2 hours , Take it out immediately, and make a white powder after...

Embodiment 2

[0046] The preparation method of the present invention comprises the following steps:

[0047] 1) Press Ca(NO 3 ) 2 4H 2 O and H 3 PO 4 The molar ratio is 3:2 to weigh raw materials, Ca(NO 3 ) 2 4H 2 O was mixed with distilled water at a mass ratio of 1:12, and then H 3 PO 4 Mix with distilled water at a mass ratio of 1:90, and then add H 3 PO 4 Aqueous solution was added to Ca(NO 3 ) 2 The solution is mixed evenly to obtain a mixed solution, and the pH of the mixed solution is adjusted with NaOH solution so that the pH value of the mixed solution system is maintained at 11-12, and then the mixed solution is centrifuged, continuously washed, and suction filtered.

[0048] 2) Put the product obtained in step 1) into a muffle furnace, heat and keep it at 150°C for 1.5 hours, take it out, grind it, then put it into a corundum crucible and raise the temperature to 1400°C at 10°C / min, and keep it warm for 0.5 hours, Take it out immediately, and after cooling, the white...

Embodiment 3

[0052] The preparation method of the present invention comprises the following steps:

[0053] 1) Press Ca(NO 3 ) 2 4H 2 O and H 3 PO 4 The molar ratio is 3:2 to weigh raw materials, Ca(NO 3 ) 2 4H 2 O was mixed with distilled water at a mass ratio of 1:14, and then H 3 PO 4 Mix with distilled water at a mass ratio of 1:80, and then add H 3 PO 4 Aqueous solution was added to Ca(NO 3 ) 2 The solution is mixed uniformly to obtain a mixed solution, and the pH of the mixed solution is adjusted with NaOH solution so that the pH value of the mixed solution system is maintained at 13-14, and then the mixed solution is centrifuged, continuously washed, and suction filtered.

[0054] 2) Put the precipitate obtained in step 1) into a muffle furnace, heat it at 100°C for 2 hours, take it out, grind it, then put it into a corundum crucible and raise the temperature to 1350°C at 10°C / min, and keep it warm for 1 hour , Take it out immediately, and make a white powder after cool...

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Abstract

The invention relates to a preparation method of a hydroxyapatite material doped with fluorine and potassium. The preparation method of the hydroxyapatite material doped with fluorine and potassium comprises the following steps: (1) uniformly mixing a Ca(NO3)2.4H2O aqueous solution with a H3PO4 aqueous solution to obtain a mixed solution, adjusting pH value of the mixed solution till sediment is generated, separating out the sediment and washing the sediment; (2) drying the sediment obtained by the step (1), calcining the sediment at the temperature of 1300-1500 DEG C, and then quickly cooling the sediment to prepare alpha-calcium phosphate powder; (3) dispersing the alpha-calcium phosphate powder prepared by the step (2) in an alkaline solution containing K<+> and F<->, standing and aging at 80-160 DEG C for more than 12 hours, separating out powder, and then washing and drying to prepare the hydroxyapatite material doped with fluorine and potassium. By virtue of the preparation method, the problems that potassium salt is easily dissolved in water and not easily doped in the hydroxyapatite are solved; nanocrystals of the prepared hydroxyapatite material doped with fluorine and potassium are small in grain size and high in crystal purity, so that the hydroxyapatite material doped with fluorine and potassium can be taken as a novel method with functions of treating hypersensitive dentin, desensitizing and repairing and is long-term and efficient in treatment on hypersensitive dentin.

Description

technical field [0001] The invention relates to the field of preparation of hydroxyapatite materials, in particular to a preparation method of fluorine-doped potassium hydroxyapatite materials. Background technique [0002] Fluoride has been widely used in biomedical materials, such as treating osteoporosis or enhancing the acid erosion resistance of teeth. It has been reported that fluoride ions promote mineralization and bone formation by stimulating the proliferation and differentiation of bone cells. Studies have shown that fluoride ions contain Fluorine hydroxyapatite has obvious high-temperature thermal stability and biological activity, and the lattice energy of hydroxyapatite materials in which fluoride ions are partially replaced or completely replaced by hydroxide ions improves the acid resistance of these hydroxyapatites. , In addition, fluorinated hydroxyapatite coatings can promote cell proliferation and bone growth, however, in practice, due to the difficulty o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K6/033A61K6/838
Inventor 殷海荣李思媛吴阳刘盼李艳肖
Owner SHAANXI UNIV OF SCI & TECH
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