Preservative liquid for corpses, tissue and dissections, and application method thereof

A technology for preserving liquids and corpses, which is applied in the field of antiseptic preservation liquids for corpses, tissues and anatomies, and achieves the effects of less harm to the environment and human health, less irritation, and convenient application

Active Publication Date: 2014-10-15
民政部一零一研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the shortcomings of the existing body (corpse) preservatives based on formaldehyde and peroxide, further improve the performance of the existing antiseptic preservation solution, and adapt to the antiseptic preservation requirements of various environments and regions, it is urgent to develop a high-efficiency, A low-toxic, environmentally friendly antiseptic preservati

Method used

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  • Preservative liquid for corpses, tissue and dissections, and application method thereof

Examples

Experimental program
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Example Embodiment

[0021] Example 1: Soaking and anticorrosive preservation experiment

[0022] After intraperitoneally injecting 10 mL of the antiseptic preservation solution of the present invention into each mouse in the specimen bottle, soak in the antiseptic to observe the antiseptic effect of the mice. The Spanish Complucad preservative was used as a control, and sterilized saline was used as a blank control. The experimental mice were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences, male, strain: KM, weighing 29-34 g.

[0023] The mice were soaked and preserved for 12 months (2010-2011). The mice using the antiseptic preservation solution of the present invention have normal color, good elasticity, no corruption, no mold growth, and the preservation solution is slightly yellow, clear and transparent; use The mice with Complucad preservative were transparent and had severe atrophy; the mice in the normal saline control group had turned black, moldy, an...

Example Embodiment

[0024] Example 2: Laboratory rat injection antiseptic experiment

[0025] After the three groups of experimental rats were sacrificed, they were injected with preservatives into the heart at a dose of 25 mL / 100 g, placed in a cool, ventilated and dry place, and stored at room temperature for 30 days to observe the antiseptic effect. On the 3rd, 7th, 14th, and 30th days of the experiment, one rat was taken for dissection, and skeletal muscle, intestine, heart, lung, liver, kidney, brain and other tissues were cut out, fixed, and paraffin sectioned. Wood-Eosin staining, microscope observation and photographing. This experiment uses FineFIX preservative as a control (FineFIX is a new formalin-free fixative patented by Milestone, Italy for morphological research), and sterilized normal saline is used as a blank control. The experimental rats were clean-grade Wistar rats, purchased from the Experimental Animal Center of the Academy of Military Medical Sciences, male, weighing about 1...

Example Embodiment

[0029] Example 3: Antiseptic experiment of medical school body

[0030] In a medical university, an adult male body (weight about 60Kg) was selected, arterial perfusion and chest and abdominal cavity injection of the antiseptic preservation solution of the present invention about 25000mL, placed in an environment of 4 ℃, closely observe the results of the antiseptic experiment. After 50 days, the remains showed no obvious corruption and no smell from the appearance. The heart, liver, spleen, lung, kidney, stomach, large intestine, small intestine and skin were taken separately, wrapped in paraffin and sectioned, stained with HE, and observed by high power microscope. It can be seen from the figure that the use of the antiseptic preservation solution of the present invention can basically maintain the inherent morphology and structure of various cells and tissues of the human body.

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Abstract

The invention provides a preservative liquid for corpses, tissue and dissections and an application method thereof. The preservative liquid mainly comprises 0.5 to 2% by mass of glutaraldehyde, 0.3 to 3% by mass of thymol, 0.5 to 3% by mass of sodium benzoate, 0.1 to 1% by mass of sodium citrate (or citric acid), 0.5 to 3% by mass of mannitol (or D-sorbitol), 40 to 65% by volume of ethanol, 5 to 15% by volume of glycerol, 1 to 5% by volume of organic acid, 0 to 1% by volume of essence and 14 to 54% by volume of water. The preservative liquid can realize preservation and fixation of corpses, tissue and dissections via a soaking or perfusion method and exerts anticorrosive, preservative, disinfecting and stink-removing effects. According to results of animal experiments of the preservative liquid in a laboratory, on-site experiments in a mortuary house, etc., the preservative liquid has high efficiency bacteriostatic performance, safety and low toxicity and is applicable to preservation of corpses, tissue and dissections in medical teaching and scientific research and funeral services.

Description

technical field [0001] The invention relates to the antiseptic preservation technology of corpses in the field of human anatomy teaching and scientific research and in the field of funerals, in particular to an antiseptic preservation solution for corpses, tissues and anatomical objects and a method for using the same. Background technique [0002] Understanding the structure of the human body, exploring the mysteries of the human body, and the needs of modern funeral services are inseparable from the research of autopsy and tissue cells, requiring a set of scientific embalming and preservation techniques for corpses, tissues, and organs. After the death of a person or animal, if the body is not embalmed and fixed, autolysis and decay of the tissue will occur soon. Civil affairs funeral service units also often use corpse embalming technology when carrying out international transportation of corpses and preservation of remains. [0003] Commonly used corpse preservation met...

Claims

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Application Information

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IPC IPC(8): A01N1/00
Inventor 李玉光杨德慧李伯森周雪媚王永阔姜思朋孟浩单云官
Owner 民政部一零一研究所
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