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Preservative liquid for corpses, tissue and dissections, and application method thereof

A technology for preserving liquids and corpses, which is applied in the field of antiseptic preservation liquids for corpses, tissues and anatomies, and achieves the effects of less harm to the environment and human health, less irritation, and convenient application

Active Publication Date: 2014-10-15
民政部一零一研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the shortcomings of the existing body (corpse) preservatives based on formaldehyde and peroxide, further improve the performance of the existing antiseptic preservation solution, and adapt to the antiseptic preservation requirements of various environments and regions, it is urgent to develop a high-efficiency, A low-toxic, environmentally friendly antiseptic preservation solution for corpses, tissues and anatomies. By soaking or arterial perfusion of the corpse, suction and injection of the body cavity, etc., it can effectively prevent the growth and spread of pathogenic microorganisms in the corpse, and control the autolysis and corruption of the corpse. Development to benefit medical anatomical research or embalming preservation of funeral home remains

Method used

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  • Preservative liquid for corpses, tissue and dissections, and application method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1: immersion anticorrosion preservation experiment

[0022] After each mouse was intraperitoneally injected with 10 mL of the antiseptic preservation solution of the present invention in the specimen bottle, it was soaked in the antiseptic to observe the antiseptic effect of the mice. Spanish Complucad preservative was used as the control, and sterilized saline was used as the blank control. Experimental mice were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences, male, strain: KM, weighing 29-34 g.

[0023] The mice were soaked and preserved for 12 months (2010-2011), and the mice using the antiseptic preservation solution of the present invention had normal color, good elasticity, no corruption phenomenon in appearance, no mold growth, and the preservation solution was slightly yellow and clear; The body of the mice treated with Complucad preservative was transparent and showed severe atrophy; the mice in the normal ...

Embodiment 2

[0024] Embodiment 2: Injection antisepsis experiment on laboratory rats

[0025] After the three groups of experimental rats were killed, the preservative was injected into the heart at a dose of 25mL / 100g, placed in a cool, ventilated and dry place, stored at room temperature for 30 days, and the antiseptic effect was observed. On the 3rd day, 7th day, 14th day, and 30th day of the experiment, one rat was taken for dissecting, and the skeletal muscle, intestine, heart, lung, liver, kidney, brain and other tissues were cut out respectively, fixed, paraffin sectioned, and retrieved. Xylin-eosin staining, microscope observation and photography. In this experiment, FineFIX preservative was used as control (FineFIX is a new formalin-free fixative patented by Italian Milestone for morphological research), and sterilized saline was used as blank control. The experimental rats are clean grade Wistar rats, purchased from the Experimental Animal Center of the Academy of Military Medic...

Embodiment 3

[0029] Example 3: Anti-corrosion experiment of medical school remains

[0030] Select an adult male corpse (about 60Kg) in a medical university, arterially perfuse and inject about 25,000 mL of the antiseptic preservation solution of the present invention into the chest and abdominal cavity, place it in an environment at 4°C, and closely observe the results of the antiseptic experiment. After 50 days, there was no obvious corruption or odor from the appearance of the remains. The heart, liver, spleen, lung, kidney, stomach, large intestine, small intestine, and skin were taken out, wrapped in paraffin, sectioned, stained with HE, and observed through a high-power microscope. It can be seen from the figure that using the antiseptic preservation solution of the present invention can basically maintain the inherent shape and structure of each cell and tissue of the human body.

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Abstract

The invention provides a preservative liquid for corpses, tissue and dissections and an application method thereof. The preservative liquid mainly comprises 0.5 to 2% by mass of glutaraldehyde, 0.3 to 3% by mass of thymol, 0.5 to 3% by mass of sodium benzoate, 0.1 to 1% by mass of sodium citrate (or citric acid), 0.5 to 3% by mass of mannitol (or D-sorbitol), 40 to 65% by volume of ethanol, 5 to 15% by volume of glycerol, 1 to 5% by volume of organic acid, 0 to 1% by volume of essence and 14 to 54% by volume of water. The preservative liquid can realize preservation and fixation of corpses, tissue and dissections via a soaking or perfusion method and exerts anticorrosive, preservative, disinfecting and stink-removing effects. According to results of animal experiments of the preservative liquid in a laboratory, on-site experiments in a mortuary house, etc., the preservative liquid has high efficiency bacteriostatic performance, safety and low toxicity and is applicable to preservation of corpses, tissue and dissections in medical teaching and scientific research and funeral services.

Description

technical field [0001] The invention relates to the antiseptic preservation technology of corpses in the field of human anatomy teaching and scientific research and in the field of funerals, in particular to an antiseptic preservation solution for corpses, tissues and anatomical objects and a method for using the same. Background technique [0002] Understanding the structure of the human body, exploring the mysteries of the human body, and the needs of modern funeral services are inseparable from the research of autopsy and tissue cells, requiring a set of scientific embalming and preservation techniques for corpses, tissues, and organs. After the death of a person or animal, if the body is not embalmed and fixed, autolysis and decay of the tissue will occur soon. Civil affairs funeral service units also often use corpse embalming technology when carrying out international transportation of corpses and preservation of remains. [0003] Commonly used corpse preservation met...

Claims

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Application Information

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IPC IPC(8): A01N1/00
Inventor 李玉光杨德慧李伯森周雪媚王永阔姜思朋孟浩单云官
Owner 民政部一零一研究所
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