A kind of germanium nanocluster, its preparation method and use

A nano-cluster, germanium dioxide technology, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the application limitations in the field of optical and optoelectronic devices, low fluorescence quantum yield, and no semiconductor metal clusters are seen. Cluster reporting, etc.

Active Publication Date: 2016-08-10
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
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Problems solved by technology

[0002] Silicon and germanium of the fourth main group, as indirect bandgap semiconductor materials, have been widely used in the field of microelectronics in the past few decades, but due to the extremely low fluorescence quantum yield at room temperature, their applications in the field of optical and optoelectronic devices has been limited
[0005] But so far, we have not seen reports of semiconductor metal clusters with fluorescent properties

Method used

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  • A kind of germanium nanocluster, its preparation method and use
  • A kind of germanium nanocluster, its preparation method and use
  • A kind of germanium nanocluster, its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Synthesize water-soluble germanium clusters as follows:

[0069] (1) Weigh 0.06g of sodium hydroxide and dissolve it in 10ml of water, and ultrasonically dissolve it to make a sodium hydroxide solution;

[0070] (2) Weigh 0.26g germanium dioxide (GeO 2 , purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 483702) was dissolved in the sodium hydroxide solution in step (1), and ultrasonically dissolved to obtain a germanium source solution;

[0071] (3) Dissolving the germanium source in a sodium hydroxide solution under ultrasonic radiation conditions to prepare a germanium source solution, and adjusting the pH value of the germanium source solution in step (2) to between 6 and 7 with dilute hydrochloric acid;

[0072] (4) Add 1.21g of cysteine ​​(purchased from Sigma Aldrich Shanghai Trading Co., Ltd., product number 30089-25G) into 9ml of ultrapure water, stir to fully dissolve cysteine, and prepare cysteine The aqueous solution; The concentration...

Embodiment 2

[0081] In this example, germanium clusters were prepared according to the same method as in Example 1, the only difference being that the amount of cysteine ​​used was 0.121 g.

[0082] According to the same characterization method in Example 1, the fluorescence spectrum of the germanium clusters obtained in this comparative example is very different from Example 1 by using a fluorescence spectrometer, the emission peak position is red-shifted to 530nm, and the excitation peak position is blue-shifted to 385nm. Using sodium fluorescein as a fluorescent standard substance to measure the fluorescence quantum yield of the germanium clusters obtained in this embodiment is above 20%, indicating that the proportioning concentration of cysteine ​​and germanium sources has a certain effect on the fluorescent properties of the synthesized clusters. Impact.

Embodiment 3

[0084] (1) Weigh 0.02g of potassium hydroxide and dissolve it in 10ml of water, and ultrasonically dissolve it to make sodium hydroxide solution;

[0085] (2) Weigh 0.026g germanium dioxide (GeO 2 , purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 483702) was dissolved in the sodium hydroxide solution in step (1), and ultrasonically dissolved to obtain a germanium source solution;

[0086] (3) Under the condition of ultrasonic radiation, dissolving the germanium source in a sodium hydroxide solution to prepare a germanium source solution, and adjusting the pH value of the germanium source solution in step (2) to 9 with dilute hydrochloric acid;

[0087] (4) Add 0.0605g of cysteine ​​(purchased from Sigma-Aldrich Shanghai Trading Co., Ltd., product number 30089-25G) into 9ml of ultrapure water, stir to fully dissolve cysteine, and prepare cysteine The aqueous solution; The concentration of the aqueous solution of cysteine ​​is 0.05mmol / ml;

[0088] (5) ...

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Abstract

The invention relates to a germanium fluorescent cluster, a preparation method of the germanium fluorescent cluster in aqueous solution and its application in biological imaging. The synthesis method uses germanium dioxide as germanium source, biomolecular cysteine ​​as protective agent, and sodium borohydride as reducing agent to prepare monomolecular-layer protected germanium nanoclusters with fluorescent properties. The raw materials used in the present invention are simple, easy to obtain, stable in nature, and non-toxic; the reaction process does not require the protection of high temperature and inert gas, and is simple and easy to operate; the obtained germanium quantum dots with emerald green or yellow fluorescence are in phase with the previously reported noble metal nanoclusters. It has a higher fluorescence quantum yield, and the cluster size is about 1nm. It has good water solubility and no cytotoxicity, and can be well applied to biological cell imaging.

Description

technical field [0001] The invention relates to a germanium nanocluster, its preparation method and application, in particular to a germanium nanocluster with strong fluorescence properties, its preparation method and its application in biological imaging. Background technique [0002] Silicon and germanium of the fourth main group, as indirect bandgap semiconductor materials, have been widely used in the field of microelectronics in the past few decades, but due to the extremely low fluorescence quantum yield at room temperature, their applications in the field of optical and optoelectronic devices has always been limited. In recent years, with the rapid development of nanotechnology, new breakthroughs have been made in the research of semiconductor materials silicon and germanium. When they are at the nanometer scale, due to the quantum confinement effect, they will transform into nanomaterials with direct band gaps, showing different characteristics. The unique physical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24C09K11/66G01N21/64
Inventor 聂广军李凤
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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