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Expanded bed adsorption matrix and preparation method thereof

An adsorption matrix and expanded bed technology, applied in the field of expanded bed adsorption, can solve the problems affecting adsorption matrix research, low acrylamide aqueous solution, difficult to embed weighting agent, etc., achieve controllable pore size and pore size distribution, and low cost , the effect of good biocompatibility

Active Publication Date: 2014-12-03
ZHEJIANG UNIV
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  • Description
  • Claims
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Problems solved by technology

During the formation of polyacrylamide gel microspheres, acrylamide monomers are polymerized under the action of crosslinking agents and initiators. Therefore, in order to increase the density of polyacrylamide gel microspheres, it is necessary to However, due to the low viscosity of the acrylamide aqueous solution, it is difficult to embed the weighting agent during polymerization, especially the denser weighting agent, such as stainless steel, tungsten carbide, etc.
This problem has not been well solved, and it directly affects the research on the preparation of expanded bed adsorption matrix with polyacrylamide as the basic material.

Method used

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  • Expanded bed adsorption matrix and preparation method thereof
  • Expanded bed adsorption matrix and preparation method thereof
  • Expanded bed adsorption matrix and preparation method thereof

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preparation example Construction

[0027] The preparation method of expanded bed adsorption matrix comprises the steps:

[0028] 1) Mix monomer acrylamide and cross-linking agent at a molar ratio of 40:1 to 30:1 to prepare a solution with a total mass concentration of 20% to 50%;

[0029] 2) Add the starch into deionized water, heat and stir until it becomes a paste, and prepare a transparent and uniform colloidal liquid, that is, a gelatinized starch solution. The mass concentration of the gelatinized starch solution is 5% to 10%; the gelatinized starch solution Add it to the acrylamide / crosslinking agent solution prepared in step 1), so that the mass ratio of the gelatinized starch solution to the acrylamide / crosslinking agent solution is 1:10 to 5:10; add weighting agent particles to increase the weight The mass ratio of the weighting agent particles to the acrylamide / crosslinking agent solution is 0.1-1.3:1, mix and stir evenly, and carry out ultrasonic dispersion at 20-35°C, so that the weighting agent par...

Embodiment 1

[0037] 1) acrylamide and crosslinking agent N, N'-methylenebisacrylamide are mixed in a molar ratio of 40:1 to prepare a solution with a total mass concentration of 20%;

[0038] 2) Add sweet potato starch to deionized water, heat and stir until it becomes a paste, and prepare a transparent and uniform colloidal liquid, the mass concentration of the gelatinized starch solution is 5%; add the gelatinized starch solution to the prepared acrylamide / crosslinking agent solution, the mass ratio of starch solution to acrylamide / crosslinking agent solution is 1:10; adding weighting agent titanium dioxide particles, the mass ratio of weighting agent particles to acrylamide / crosslinking agent solution is 1:5 , mix and stir evenly, carry out ultrasonic dispersion at 20°C, so that the weighting agent particles are evenly dispersed in the solution;

[0039] 3) At 0°C, add the initiator ammonium persulfate into the dispersed solution, the mass ratio of ammonium persulfate to acrylamide is ...

Embodiment 2

[0043] 1) acrylamide and crosslinking agent N, N'-methylenebisacrylamide are mixed in a molar ratio of 30:1 to prepare a solution with a total mass concentration of 50%;

[0044] 2) Add tapioca starch to deionized water, heat and stir until it becomes a paste, and prepare a transparent and uniform colloidal liquid, the mass concentration of the gelatinized starch solution is 10%; add the gelatinized starch solution to the prepared In the acrylamide / crosslinking agent solution, the mass ratio of starch solution to acrylamide / crosslinking agent solution is 5:10; adding weighting agent tungsten carbide particles, the mass ratio of weighting agent particles to acrylamide / crosslinking agent solution 1.3:1, mix and stir evenly, ultrasonically disperse at 35°C, so that the weighting agent particles are evenly dispersed in the solution;

[0045] 3) At 5°C, add the initiator ammonium persulfate into the dispersed solution, the mass ratio of ammonium persulfate to acrylamide is 5:100, s...

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Abstract

The invention discloses an expanded bed adsorption matrix and a preparation method thereof. The preparation method comprises the following steps: 1) dissolving acrylamide, a crosslinking agent and a water-soluble gelatinized starch colloid liquid in deionized water; 2) adding inorganic weighting agent particles into the mixed solution, and uniformly dispersing; 3) adding an initiator into the uniformly dispersed solution, adding the solution into a dispersing-agent-dissolved continuous phase (oil phase) to constitute a reversed phase suspension disperse system; 4) heating the reversed phase suspension disperse system to carry out polymerization reaction; 5) after the reaction is finished, removing the continuous phase, cleaning, and adding amylase to remove the water-soluble starch, thereby obtaining composite microspheres; and 6) filtering the composite microspheres, washing, and carrying out wet screening to finally obtain the expanded bed matrix using polyacrylamide as the base material. The expanded bed matrix has the advantages of favorable sphericity, higher density, larger pore size, reasonable particle size distribution, favorable mechanical strength, favorable biocompatibility, stable properties, low cost and the like.

Description

technical field [0001] The invention relates to the technical field of expanded bed adsorption, in particular to an expanded bed adsorption matrix and a preparation method thereof. Background technique [0002] Expanded bed adsorption technology is an integrated separation technology that integrates solid-liquid separation, enrichment and concentration, and initial purification in one unit operation, and can directly capture target products from fermentation broth or cell homogenate. The expanded bed adsorption matrix with excellent performance is the key to expanded bed adsorption, which directly affects the mass transfer and separation efficiency of the separation process. Special design is required for the expanded bed adsorption matrix, including a reasonable particle size distribution and a reasonable particle density distribution. At the same time, the flow rate of the expanded bed adsorption process is high, and the matrix needs to have a large pore size to facilitate...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08L33/26C08F251/00C08F220/56C08F2/32B01J20/26B01D15/08
Inventor 姚善泾鲁丹萍占晓勇林东强
Owner ZHEJIANG UNIV
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