Preparation method of luminescence rare earth coordination polymer nanoparticles

Abstract

The invention relates to a preparation method of luminescence rare earth coordination polymer nanoparticles. The luminescence rare earth coordination polymer nanoparticles are obtained through a self-assembly one-step reaction of a biomolecular base, rare earth ions and a micro-molecular ligand by the method. The rare earth coordination polymer nanoparticles prepared in the invention have the characteristics of spherical and porous property, uniform size and composition, luminescence property of the rare earth ions, and good biocompatibility and hydrophilicity. Compared with common preparation methods of the rare earth nanoparticles, the method provided by the invention has the advantages of avoiding of the complex organic synthesis of the ligand, avoiding of an embedding / doping or surface modification / adsorption step, and simplicity. The prepared rare earth nanoparticles have good application prospects in the fields of luminescence display, molecule sensing, tracing imaging, drug delivery and the like.

Description

technical field [0001] The invention relates to a method for preparing luminescent rare earth coordination polymer nanoparticles. The prepared rare earth coordination polymer nanoparticles can be applied to luminescent display, molecular sensing, trace imaging, drug delivery, etc., and belong to luminescent nanoparticles technology field. Background technique [0002] Fluorescence detection and imaging technologies are widely used in life sciences, medicine, food, environment and many other fields. Traditional fluorescence analysis uses various organic dye molecules as luminescent markers. However, organic dye molecules are easily interfered by various non-specific fluorescence. (excitation light, scattered light and analyte background fluorescence), and dye molecules are prone to photobleaching and quenching effects, resulting in a decrease in fluorescence intensity. Rare-earth luminescent molecules with long luminescence lifetimes allow the use of time-resolved fluorescen...

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Problems solved by technology

Since these methods use non-solution homogeneous preparation, the uniformity of the shape of the prepared particles, the controllability of the size, and the dispersion in the aqueous solution are not ideal.

[0004] Chinese Patent Publication No. CN 1493647A, 2004, Yuan Jingli, Tan Mingqian, Ye Zhiqiang, Wang Guilan, a functional nano-rare earth fluorescent particle and its preparation and application, discloses a SiO 2 The particle preparation method of encapsulating rare earth complexes, the prepared particles have good uniformity and strong fluorescence intensity, and can be used for time-resolved fluorescence analysis, but the ligands of the rare earth complexes used need to be specially synthesized through organic reactions, and the ligand preparation is complex and not readily available

[0006] The present invention utilizes the molecular self-assembly of base molecules, rare earth ions and dipicolinic acid to synthesize spherical rare earth coordination polymer nanoparticles with uniform size, which has not been reported at home and abroad.

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