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A kind of porous hydroxyapatite bioceramic and preparation method thereof

A technology of hydroxyapatite and water-based hydroxyapatite is applied in the field of porous hydroxyapatite bioceramic and its preparation to achieve the effect of large compressive strength

Active Publication Date: 2016-02-03
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no porous hydroxyapatite bioceramic material well suited for bone tissue growth

Method used

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  • A kind of porous hydroxyapatite bioceramic and preparation method thereof
  • A kind of porous hydroxyapatite bioceramic and preparation method thereof
  • A kind of porous hydroxyapatite bioceramic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Add 100 g of deionized water, 1 g of polyacrylamide, 1 g of polyvinyl alcohol, and 5 g of hydroxyapatite powder into the ball mill tank, and after ball milling for 20 hours, water-based hydroxyapatite slurry is obtained;

[0025] 2) Fix the two ends of the mold with a polyester braided net with a diameter of 185 μm, and then use a polyester thread with a diameter of 165 μm to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0026] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification (that is, control the temperature and cooling rate at both ends of the mold by controlling the flow rate of liquid nitrogen at both ends of the mold, Realize the directional solidification of ice crystals, the same below), control the cooling rate to 5°C / min, and then freeze-dry the frozen green body in a freeze dryer;

[0027] 4) The drie...

Embodiment 2

[0029] 1) Add 95 g of deionized water, 0.5 g of polyacrylamide, 0.5 g of polyvinyl alcohol, and 35 g of hydroxyapatite powder into the ball mill tank, and after ball milling and mixing for 30 hours, water-based hydroxyapatite slurry is obtained;

[0030] 2) Fix nylon braided nets with a diameter of 530 μm at both ends of the mold, and then use nylon wires with a diameter of 510 μm to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0031] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification, control the cooling rate to 3°C / min, and then freeze-dry the frozen green body in a freeze dryer ;

[0032] 4) The dried body was sintered at 1300°C, and after sintering for 1 hour, it was cooled to room temperature with the furnace temperature to obtain a porous hydroxyapatite ceramic with a pore diameter of 500 μm and a lamellar oriented ...

Embodiment 3

[0034] 1) Add 105g of deionized water, 2g of polyacrylamide, 2g of polyvinyl alcohol, and 150g of hydroxyapatite powder into the ball mill tank, and after ball milling and mixing for 20 hours, water-based hydroxyapatite slurry is obtained;

[0035] 2) Fix the two ends of the mold with a polyester braided net with a diameter of 1060 μm, and then use a polyester thread with a diameter of 1050 μm to pass through the mesh holes at both ends, so that they are oriented in the mold;

[0036] 3) After injecting the water-based hydroxyapatite slurry into the mold, put it into a container filled with liquid nitrogen for low-temperature directional solidification, control the cooling rate to 0.5°C / min, and then freeze-dry the frozen green body in a freeze dryer ;

[0037] 4) The dried green body was sintered at 1250°C, and after sintering for 1.5 hours, it was cooled to room temperature with the furnace temperature to obtain a porous hydroxyapatite ceramic with a pore diameter of 1000 μm...

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Abstract

Disclosed are a porous hydroxyapatite bioceramic and a preparing method thereof. The porous hydroxyapatite bioceramics of the present invention has suitable pore diameters and distribution, porosity, pore-through situations, and pore surface morphology for bone tissue growth, and not only has large pores allowing a new bone to grow into, but also has abundant flake-shaped pores in pore walls, thus transferring osteogenesis. In the preparing method of the present invention, diameters and distribution of polymeric fibers are arranged appropriately in a die in advance, aqueous hydroxyapatite slurry is frozen and solidified by using orientated temperature field to make hydroxyapatite powder particulates to agglomerate and rearrange under of pushing and thrusting of an orientated grown ice crystal, a resulting ice block is frozen and dried to sublime the ice crystal before sintering is performed. The method can perform fine regulating may be performed on the porous microstructure. And porous hydroxyapatite prepared by the present invention has the high pore-through rate and the high porosity, suitable for bone tissue growth.

Description

technical field [0001] The invention relates to a porous hydroxyapatite bioceramic and a preparation method thereof. Background technique [0002] At present, there is still a lack of satisfactory bone substitute materials for the repair of long bone injuries and defects caused by trauma, inflammation, and tumor resection, which has become a medical problem that needs to be solved urgently. At present, the main clinical methods for repairing long bone injuries are autologous bone transplantation, allogeneic bone, allogeneic bone transplantation and artificial bone replacement. Autologous bone grafting is the "gold standard" for the treatment of bone defects, but when repairing large bone defects, it causes damage to the donor site tissue, the amount of bone donor is limited, and complications are prone to occur, making it difficult to achieve a satisfactory therapeutic effect. Although bone allograft and allograft bone transplantation can avoid damage to the donor site tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56
CPCA61L27/12A61L27/50A61L27/56A61L2400/08A61L2430/02
Inventor 周科朝黄智张斗李志友张妍陈良建
Owner CENT SOUTH UNIV
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