Lanthanum rare-earth coordinated chitosan quaternary ammonium salt gynecological gel for external use and preparation method thereof

Abstract

The invention discloses a lanthanum rare-earth coordinated chitosan quaternary ammonium salt gynecological gel for external use and a preparation method thereof. The chitosan quaternary ammonium salt gynecological gel for external use is characterized in that lanthanum rare-earth metals and chitosan quaternary ammonium salt are connected through a coordination bond, wherein the molecular weight of the chitosan quaternary ammonium salt is above 14000; and the substitution degree of a quaternary ammonium group is 0.90-0.95. According to the invention, the rare-earth metals are coordinated on a chitosan quaternary ammonium salt matrix skeleton through a covalent bond, so that the excellent antibacterial property of a rare-earth compound is combined with the good property of a chitosan matrix; the sterilizing property of the chitosan quaternary ammonium salt is increased; a high-efficiency and steady multi-antibacterial material is prepared; the gel for external use disclosed by the invention has the good moisture-preserving, deodorizing, and multi-antibacterial effects; furthermore, the antibacterial spectrum is wide; the gel for external use does not have irritation to skin; normal flora and acid-base balance in a vagina cannot be influenced; drug dependence cannot be generated; and the rare-earth coordinated chitosan quaternary ammonium salt gynecological gel for external use disclosed by the invention can absorb and preserve moisture and has air permeability and good biological fitness and biodegradability.

Description

technical field [0001] The invention relates to a gel for external use in gynecology, in particular to a gel for external use in gynecology with lanthanide rare earth coordination chitosan quaternary ammonium salt. Background technique [0002] Gynecological inflammation is a common disease of women, such as female vulvitis, vaginitis, and cervicitis. Gynecological topical gel is widely used in the treatment of gynecological inflammation due to its advantages of non-adhesion to the wound surface, effective blocking of bacteria, and prevention of wound infection. Large, the skin is prone to allergic reactions, long-term use will not only cause certain damage to the body, but also the body will develop drug resistance, affecting the efficacy of the drug and the therapeutic effect, and the biological adaptability of the synthetic macromolecular gel matrix and biodegradability are poor, affecting its use as a gynecological external gel. [0003] Patent CN 102204880 A discloses...

AI Technical Summary

Problems solved by technology

Gynecological topical gel is widely used in the treatment of gynecological inflammation due to its advantages of non-adhesion to the wound surface, effective blocking of bacteria, and prevention of wound infection. Large, the skin is prone to allergic reactions, long-term use will not only cause certain damage to the body, but also the body will develop drug resistance, affecting the efficacy of the drug and the therapeutic effect, and the biological adaptability of the synthetic macromolecular gel matrix and biodegradability are poor, affecting its use as a gynecological external gel

[0003] Patent CN 102204880 A discloses a gynecological external-use disinfectant gel and its preparation method. The gel matrix itself does not contain bactericidal ingredients, and it needs to add bactericides or other surface active substances to have anti-inflammatory effects. Although It has a good bactericidal effect, but the bactericidal ingredients added in addition are likely to irritate the skin, and it is easy to affect the normal flora and acid-base balance in the vagina, and it is easy to cause drug dependence; patent CN 101926875 A discloses a treatment for gynecological inflammation The gel and its preparation method are prepared by using extracts extracted from various traditional Chinese medicines, borneol and auxiliary materials, etc., which require a variety of chemical reagents, which are easy to cause irritation to the skin, and the preparation process is various, and the onset is slow