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Application of kigelia pinnata DC. ketone in preparing antibacterial drugs

A technology of antibacterial drugs and chandelier, which is applied in the field of medicine, can solve the problems of antibacterial drugs or health care products without chandelier tree ketone, and achieve the effect of large processing capacity, fast separation speed and simple operation

Inactive Publication Date: 2015-01-07
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through literature search, there has not been any chandelierone used in the preparation of antibacterial drugs or health care products in China

Method used

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  • Application of kigelia pinnata DC. ketone in preparing antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The dry roots of the chandelier tree are crushed, 1 kg is added to a supercritical extraction kettle, and liquid CO is introduced 2 , set the extraction pressure to 25MPa, and the temperature to 40°C. After reaching the above parameters, adjust the liquid CO 2 The flow rate is 4ml / g crude drug / min, 95% ethanol solution is used as entrainer, the amount of entrainer is 15% of the total extraction solvent, dynamic extraction is carried out for 50min, analysis is carried out at a pressure of 7.5MPa and a temperature of 40°C, and the obtained extract is dissolved in methanol , add a small amount of neutral magnesia to mix the sample, evaporate the solvent, put it on the magnesia column by dry method, gradient elution with petroleum ether-acetone 23:3, 15:3, 5:3, 2:3 mixed solvent, collect the eluate Concentrate under reduced pressure to obtain crude extract. Take petroleum ether, ethyl acetate, methanol, and water and mix according to 6:8:7:5. After mixing and layering, tak...

Embodiment 2

[0043] Tablet: Chandelier ketone 40g, starch 135g, chenodeoxycholate 25g, granulated, compressed into 1000 tablets. Dosage: Adults take 1 tablet at a time, 2 times a day.

Embodiment 3

[0045] Capsules: Chandelier ketone 40g, starch 135g, chitosan 25g, mix well, make 1000 capsules. Dosage: Adults take 1 capsule at a time, 2 times a day.

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Abstract

The invention discloses an application of kigelia pinnata DC. ketone obtained by separating from the dry roots of kigelia pinnata DC. in preparing antibacterial drugs. The preparation method of the kigelia africana ketone comprises the following steps: a, crushing the dry roots of kigelia pinnata DC., adding the obtained powder to a supercritical extraction kettle and performing supercritical CO2 extraction with ethanol as an entrainer; b, purifying the extract by virtue of neutral magnesium oxide column chromatography, performing gradient elution by use of a petroleum ether-acetone mixed solvent, collecting the eluate and performing vacuum concentration to obtain a crude extract; c, separating the crude extract by virtue of high-speed countercurrent chromatography, monitoring by use of an ultraviolet detector, collecting the target component, and refrigerating for crystalizing to obtain colorless kigelia pinnata DC. ketone crystals. The prepared kigelia pinnata DC. ketone can be applied to preparing the antibacterial drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to chandelierone, its preparation method and its application in the preparation of antibacterial drugs. Background technique [0002] Chandelier ketone is a quinone compound isolated from the root of Bignoniaceae (Bignoniaceae) pendant tree Kigelia pinnata DC. The molecular formula is C 19 h 30 o 4 , the molecular weight is 322.43, and the structural formula is [0003] [0004] Modern studies have shown that chandelierone has antimicrobial activity. The MIC against diphtheria bacteria is 50 μg / mL. The MIC for Staphylococcus aureus, Bacillus subtilis, Aspergillus flavus and Aspergillus niger is 100μg / mL. [0005] According to the literature search, there is no chandelierone used in the preparation of antibacterial drugs or health care products in China. Contents of the invention [0006] In order to meet the clinical needs, expand the variety of drugs, and better treat bacterial inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P31/04
CPCA61K31/343
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH