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A method for extracting theophylline from theophylline mother liquor

A technology of theophylline and mother liquor, applied in organic chemistry and other fields, can solve problems such as waste, and achieve the effect of simple operation, low requirements, and rich pore size

Active Publication Date: 2016-05-18
雅安市云茶供应链管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is reported that the discharge of theophylline mother liquor from a factory with an annual output of 1,000 tons of caffeine is 12,000 tons. If it is not recycled, it will cause serious waste.
There is no report on the preparation process of theophylline in tea

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The invention provides a kind of preparation method of theophylline, comprises the following steps:

[0025] (1) Extraction of theophylline

[0026] Get theophylline mother liquor 2kg, the mass fraction of preparation its 8 times volume is the KCl solution of 3.0%, and the pH value of chlorine salt solution is adjusted to 2, when regulating the KCl solution pH value, the acid adopted is hydrochloric acid;

[0027] (2) Enrichment of theophylline

[0028] The combined extracts are adsorbed by p-hydroxybenzaldehyde adsorption resin column chromatography, and the p-hydroxybenzaldehyde adsorption resin is made by the following steps: chloromethylation reaction of styrene-divinylbenzene copolymer and chloromethyl ether , introduce the -CH2Cl active group, add dichloroethane, and swell for 14 hours; add the post-crosslinking agent p-hydroxybenzoic acid and ferric chloride under mechanical stirring, heat and reflux for 3 hours under ultrasonic conditions, cool to room temperat...

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PUM

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Abstract

The invention provides a method for extracting theophylline from theophylline mother liquor. The method comprises the following steps of (1) theophylline extraction: a chlorine salt solution is added into filtered theophylline mother liquor; (2) theophylline enrichment: the solution is subjected to a chromatographic adsorption by p-hydroxy benzaldehyde adsorption resin column, elution is carried out after the adsorption, eluant is collected, and then, pressure reduction concentration is carried out to obtain extract; and (3) purification: the extract is subjected to chromatography by an alumina column, then, elution is carried out, the eluant is collected, next, the pressure reduction concentration is carried out, concentrated liquid is subjected to refrigeration, crystallization and filtering drying, and a theophylline compound is obtained. According to the method, a large number of high-quality theophylline compounds can be obtained through four steps including acidic chloride salt solution extraction, p-hydroxy benzaldehyde adsorption resin enrichment, alumina column chromatography and crystallization. The conditions of the four steps are mild, the requirements are low, the preparation period is short, the technological process is simple, the operation is simple and convenient, the technical skill requirements on operating personnel are lower, and the method is suitable for industrial popularization.

Description

technical field [0001] The invention relates to a method for extracting theophylline from theophylline mother liquor, belonging to the technical field of organic chemistry. Background technique [0002] Theophylline is a methyl purine compound and an important component of tea. It can stimulate the central nervous system, dilate blood vessels, speed up blood circulation, enhance muscle contraction, and strengthen the heart. It is also a good diuretic, which can strengthen kidney function, facilitate urination, and excrete toxins and waste from the kidney as soon as possible. Therefore, tea can prevent kidney disease and stone disease. Theophylline's function is mainly to dissolve fat, and has the effect of eliminating indigestion and greasy. This is the reason why drinking tea can lose weight, and the effect is more significant. [0003] According to reports, the discharge of theophylline mother liquor from a factory with an annual output of 1,000 tons of caffeine is 12,00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D473/08
CPCC07D473/08
Inventor 黄帅
Owner 雅安市云茶供应链管理有限公司