Nano-emulsion containing perillaldehyde, citral and nystatin and preparation method of nano-emulsion

A technology of nystatin and nanoemulsion, applied in antifungal agents, antibacterial drugs, pharmaceutical formulations, etc., can solve problems affecting bioavailability, achieve good skin permeability, and prolong metabolic time

Active Publication Date: 2015-02-18
YANGLING XHOPE ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since perillaldehyde, citral and nystatin are insoluble

Method used

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  • Nano-emulsion containing perillaldehyde, citral and nystatin and preparation method of nano-emulsion
  • Nano-emulsion containing perillaldehyde, citral and nystatin and preparation method of nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Accurately weigh 4.5g of hydrogenated castor oil polyoxyethylene ether, 1.0g of ethanol (in which 0.1g of perillaldehyde, 0.1g of citral, and 50IU of nystatin are dissolved), 0.5g of olive oil, and stir manually at room temperature of 20°C Mix it well, then slowly add distilled water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil type Nanoemulsion, continue to drop and constantly stir, when system suddenly thins out, what produce now is O / W type colorless transparent perillaldehyde, citral, nystatin nanoemulsion, claim its weight as 10.0g.

Embodiment 2

[0038] Accurately weigh 4.5g of castor oil polyoxyethylene ether, 0.5g of ethanol (in which 0.05g of perillaldehyde, 0.05g of citral, and 60IU of nystatin are dissolved), 0.5g of isooctyl palmitate, and at room temperature of 22°C, Stir manually to mix it well, then slowly add distilled water to it, and stir manually while adding water. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal or oil. Water-type nano-emulsion, continue to drop and stir continuously, when the system suddenly becomes thinner, what is produced at this time is the O / W type light yellow transparent perillaldehyde, citral, and nystatin nano-emulsion, which weighs 10.00 g.

Embodiment 3

[0040] Accurately weigh castor oil polyoxyethylene ether 3.0g, 1,3-butanediol 1.0g (wherein dissolve perillaldehyde 0.025g, citral 0.025g, nystatin 70IU), myristyl isopropyl ester 0.44g, in At room temperature of 23°C, stir it manually to mix it evenly, then slowly add distilled water to it, and stir manually while adding water. The viscosity of the system is small at the beginning. Liquid crystal state or water-in-oil nanoemulsion appears, continue to drop and stir continuously, when the system suddenly becomes thinner, the O / W type light yellow transparent perillaldehyde, citral, nystatin nanoemulsion will be produced , which weighs 10.0g.

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Abstract

The invention discloses a nano-emulsion containing perillaldehyde, citral and nystatin. The nano-emulsion is prepared from the following raw materials by weight percent: 13.60-29.66% of a surfactant, 3.10-7.20% of oil, 0.01-2.00% of perillaldehyde, 0.01-2.00% of citral, 0.01-1.00% of nystatin, and the balance of distilled water, wherein the sum of the percentages by weight of the raw materials is 100%. The nano-emulsion can achieve better skin permeability, improves the solubility of perillaldehyde, citral and nystatin, increases the bioavailability of perillaldehyde, citral and nystatin, and further has the slow release property to prolong the metabolism time of the drum in vivo and give full play of the efficacy.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of antimicrobial medicine, in particular to a transparent and stable perillaldehyde, citral and nystatin nanoemulsion and a preparation method thereof. Background technique [0002] Perillaldehyde, citral, and nystatin have good antibacterial activity against Escherichia coli, Proteus, Membranobacter enteritidis, Staphylococcus, Candida albicans, Aspergillus niger, Trichophyton rubrum and Epidermophyton flocculus, etc. And can inhibit the growth of fungal spores or mycelium, perillaldehyde, citral and nystatin have obvious synergistic inhibitory effect on bacterial growth. It can be used for the treatment of fungal infections or other bacterial infections. Therefore, it is often used clinically for skin, nails, toenails, digestive tract, tinea, warts, angular cheilitis, otitis externa and vaginal infections. It has special effects on treating athlete's foot. Since perillal...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/107A61P31/04A61P31/10A61K31/11
CPCA61K9/1075A61K31/11A61K31/7048A61K47/44A61K2300/00
Inventor 刘兵兵李靠兴
Owner YANGLING XHOPE ANIMAL PHARMA
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