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Compound cefquinome antibacterial agent

A technology of cefquinome and antibacterial drugs, which is applied in the field of compound cefquinome antibacterial drugs, can solve the problems that the drug effect cannot be fully utilized, the drug dissolution rate is slow, and the bioavailability is poor, so as to maintain blood drug concentration and pharmacological effects , Improving bioavailability and taking convenience

Active Publication Date: 2015-02-18
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the use of cefquinome as an antibacterial drug is relatively common, and its commonly used dosage forms are powders, suspensions, etc. Although it can be absorbed from the gastrointestinal tract after oral administration, the absorption is not complete, and the dissolution rate of the drug is slow and the bioavailability is poor. etc. Insufficient, the water extract of Sophora flavescens has the defect of slow action, so that the water extract of Sophora flavescens and cefquinome are used alone, and the drug effect cannot be fully utilized

Method used

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Examples

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Embodiment 1

[0033] A compound cefquinome antibacterial drug, its dosage form is nanoemulsion, the weight percentage of nanoemulsion is composed of: Sophora flavescens aqueous extract 5.1 parts, EL40 (surfactant) 28 parts, ethanol (cosurfactant) 4 parts, 5.2 parts of cefquinome, 12 parts of soybean oil (oil), 45.7 parts of distilled water.

[0034] Accurately weigh 5.2g of cefquinome, 12g of soybean oil, 28g of EL40 and 4g of ethanol and stir evenly at room temperature (25°C), then slowly drop into it the aqueous solution in which the water extract of Sophora flavescens is dissolved. As the amount of aqueous solution increases, the viscosity of the system increases. When the amount of aqueous solution added makes the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of the system becomes thinner from the most viscous state. What is colorless and transparent compound cefquinome nanoemulsion, the amount of adding water at this moment is 45.7g, and the water ex...

Embodiment 2

[0036] A compound cefquinome antibacterial drug, its dosage form is nanoemulsion, the weight percent of nanoemulsion is composed of: Sophora flavescens aqueous extract 3.9 parts, EL40 (surfactant) 32 parts, 1,2-propanediol (cosurfactant ) 4 parts, cefquinome 8.7 parts, oleic acid (oil) 14 parts, distilled water 37.4 parts.

[0037] Its preparation method refers to embodiment 1.

Embodiment 3

[0039] A compound cefquinome antibacterial drug, its dosage form is nanoemulsion, the weight percentage of nanoemulsion is composed of: Sophora flavescens water extract 6.7 parts, RH40 (surfactant) 24 parts, glycerol (cosurfactant) 4 parts 6.7 parts of cefquinome, 13 parts of ethyl butyrate (oil), 45.6 parts of distilled water.

[0040] Its preparation method refers to embodiment 1.

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Abstract

The invention belongs to the technical field of medicines and provides a compound cefquinome antibacterial agent. The compound cefquinome antibacterial agent comprises the effective ingredients of cefquinome and radix sophorae flavescentis aqueous extract, the dosage form is an oil-in-water type nanoemulsion, the nanoemulsion comprises the following materials in parts by weight: 1-15 parts of the radix sophorae flavescentis aqueous extract, 15-40 parts of a surfactant, 0-20 parts of a cosurfactant, 1-20 parts of cefquinome, 1-20 parts of oil, and 20-70 parts of distilled water. The nanoemulsion is uniform in distribution, transparent in system, excellent in stability, relatively low in surface tension, excellent in mobility and convenient in eating, the nanoemulsion is rapidly devoured by reticuloendothelial cells after being taken, so that the medicine takes effects quickly, the constant blood concentration and the pharmacological effect are maintained, the bioavailability of the medicine is improved, the effect of the medicine is enhanced, and the amount of the medicine used and the use times are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound cefquinome antibacterial drug. Background technique [0002] Cefquinome, whose English name is Cefquinome, is white, off-white to light yellow powder, molecular formula C 23 h 24 N 6 o 5 S 2 ·H 2 SO 4 , molecular weight 626.69. [0003] Cefquinome, highly stable to β-lactamase; strong antibacterial activity, against Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteriaceae (Escherichia coli, Salmonella, Klebsiella, Citrobacter , Serratia marcescens) have a strong killing effect, and also have a good killing effect on many methicillin-resistant Staphylococci and Enterobacteriaceae; broad antibacterial spectrum, strong antibacterial activity, suitable for parenteral administration . [0004] It is mainly used in the clinical treatment of respiratory system infection of pigs and cattle caused by sensitive bacteria, mastitis of ...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/107A61P31/04A61K31/546
CPCA61K9/0002A61K9/0053A61K9/1075A61K31/546A61K36/489A61K2236/30A61K2236/331A61K2300/00
Inventor 孙江宏阮心洁李敏杨震豪
Owner HENAN SOAR VETERINARY PHARMA
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