Preparation method of calcium titanate nanofibers with one-dimensional hollow porous structure
A nanofiber and porous structure technology is applied in the manufacture of hollow filaments, preparation of spinning solutions, and artificial filaments of inorganic raw materials to achieve the effects of low cost, simple process and good biocompatibility.
Active Publication Date: 2017-02-01
ZHEJIANG UNIV
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Problems solved by technology
The hollow porous calcium titanate nanofiber drug carrier can maintain the drug concentration in a certain range to achieve drug sustained release function, but there is currently no research report on using calcium titanate nanofiber as a drug carrier material
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[0024] The method of the present invention will be described in further detail below in conjunction with the examples.
[0025] 1) Weigh 0.8169g of butyl titanate and 1.0087g of citric acid and dissolve them in 9ml of ethanol;
[0026] 2) After stirring and dissolving, add 0.5668g of calcium nitrate to the mixed solution of butyl titanate and citric acid prepared in step 1);
[0027] 3) Under slow stirring, add 3ml of dimethylformamide solution dropwise to the mixed solution of butyl titanate, citric acid and calcium nitrate prepared in step 2);
[0028] 4) Under slow stirring, add nonionic surfactant 0.1512gF127 to the mixed solution prepared in step 3);
[0029] 5) In the state of slow stirring, add 0.39g of polyvinylpyrrolidone to the mixed solution prepared in step 4), and stir for 4 hours to obtain a stable light yellow transparent sol;
[0030] 6) Put the sol prepared in step 5) into the syringe of the electrospinning device, and collect one-dimensional calcium titanat...
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Abstract
The invention discloses a preparation method of a one-dimensional hollow porous structure calcium titanate nanofiber. The method adopts a sol-gel method combined with electrostatic spinning, ethyl alcohol is taken as a solvent for dissolving titanium ions and calcium ions, dimethylformamide is taken as an auxiliary solvent for dissolving polyvinylpyrrolidone, and citric acid is utilized as an inhibitor for inhibiting the hydrolysis of titanium; by regulating and controlling the technological parameters of electrostatic spinning and utilizing a phase separation effect and a subsequent heating processing technology, the synthesis of the one-dimensional hollow porous structure calcium titanate nanofiber is realized. The preparation method is simple in technological process, easy to control and low in cost; the prepared one-dimensional hollow porous structure calcium titanate nanofiber has good crystallinity, and the diameter distribution of the fiber is 220-480 nm.
Description
technical field [0001] The invention relates to a method for preparing calcium titanate nanofibers with a one-dimensional hollow porous structure, belonging to the field of inorganic non-metallic materials. Background technique [0002] In recent decades, researchers have devoted a lot of effort to the development of high-performance drug-controlled release carrier materials. Among them, the application of porous inorganic materials, such as silicon dioxide, hydroxyapatite, and calcium phosphate, as drug-controlled release carriers has excited This kind of material has many advantages, such as high drug loading capacity, controllable release characteristics, good biocompatibility and so on. [0003] Calcium titanate is an inorganic non-metallic material with a typical perovskite structure and has good biocompatibility; at present, the research on calcium titanate in biomedicine mainly focuses on calcium titanate as a biological coating for Improve the adhesion strength of h...
Claims
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IPC IPC(8): D01F9/08D01F1/08D01D1/02D01D10/02A61K47/02
Inventor 韩高荣张秋红李翔任召辉沈鸽
Owner ZHEJIANG UNIV