Process for producing calcium carbonate employing nano-precipitation method

A nano-precipitation method, calcium carbonate technology, applied in the direction of calcium carbonate/strontium/barium, nanotechnology, nanotechnology, etc., can solve the problems of large size distribution of calcium carbonate powder, harsh and complex preparation conditions, and poor uniformity, and meet the preparation conditions Gentle and controllable, good biocompatibility, uniform size effect

Inactive Publication Date: 2015-03-25
ANHUI RUIYAN NEW MATERIAL TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the technologies have the problems of harsh and complex preparation conditions and high energy consumption. At the same time, the prepared calcium carbonate powder has a large size distribution and poor uniformity. It is urgent to develop new simple and low energy consumption preparation technologies and methods.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Arginine solution, 60mM calcium chloride solution, and 60mM sodium carbonate solution with a mass fraction of 2% were respectively configured; first, 40 mL of the arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form a mixed solution; Then, under the condition of stirring at 600rpm, the sodium carbonate mixed solution was added dropwise to 200mL of calcium chloride solution through a constant flow pump; after the dropwise addition was completed, continue to stir vigorously for 15min; after the reaction was completed, centrifuge at 3000rpm for 5min to collect The particles were precipitated and washed several times with absolute ethanol and deionized water; finally, they were dried overnight in a constant temperature oven at 60°C to collect nano calcium carbonate particle powder.

[0027] The nano-calcium carbonate particle powder is composed of nano-calcium carbonate with a diameter of 150-250nm, has a spherical shape, has a loose porous s...

Embodiment 2

[0029] Arginine solution, 40mM calcium nitrate solution, and 40mM sodium carbonate solution were respectively configured with a mass fraction of 2%; first, 40mL of the arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form a mixed solution; then , under the condition of stirring at 300rpm, then add the sodium carbonate mixed solution dropwise into 200mL calcium chloride solution through a constant flow pump; after the dropwise addition is completed, continue to stir vigorously for 15min; after the reaction is completed, centrifuge at 4000rpm for 3min to collect the particles Precipitated, washed several times with absolute ethanol and deionized water; finally placed in a constant temperature oven at 60°C to dry overnight to collect nano calcium carbonate particle powder.

Embodiment 3

[0031] Arginine solution, 60mM calcium nitrate solution, and 60mM sodium carbonate solution were respectively configured with a mass fraction of 1%; first, 40 mL of the arginine solution and sodium carbonate solution were mixed at a volume of 1:1 to form a mixed solution; then , under the condition of 500rpm stirring, then add the sodium carbonate mixed solution dropwise into 200mL calcium chloride solution through a constant flow pump; after the dropwise addition is completed, continue to stir vigorously for 15min; after the reaction is completed, centrifuge at 3500rpm for 5min to collect the particles Precipitated, washed several times with absolute ethanol and deionized water; finally placed in a constant temperature oven at 60°C to dry overnight to collect nano calcium carbonate particle powder.

[0032] The nano-calcium carbonate particle powder that embodiment 2 and 3 obtains all has the technical parameter identical with the nano-calcium carbonate particle powder that em...

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Abstract

The invention provides a process for producing calcium carbonate employing a nano-precipitation method, and belongs to the technical field of preparation methods of nano calcium carbonate particles. The process comprises the following processing steps: respectively preparing an arginine liquid, a calcium source liquid and a sodium carbonate liquid; mixing the arginine liquid with the sodium carbonate liquid to obtain a mixed liquid; dropwise adding the mixed liquid to the calcium source liquid under a vigorous stirring condition; further vigorously stirring after dropwise adding is ended; and centrifugally collecting particle sediments after reaction is ended; and washing, and drying the particle sediments with deionized water and absolute ethyl alcohol, so as to obtain nano calcium carbonate particle powder. The method has the advantages of simple preparation process, high laboratory operability, low production cost and high product yield. The process is suitable for laboratory research application and industrial production; and the prepared globular particles have the advantages of good dispersity, relatively large specific surface area and the like, and have great utilization potentiality in the fields of biomedicine and biological materials, such as control-released drug vectors and gene therapy vectors.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of nano calcium carbonate particles, in particular to a method for preparing spherical porous calcium carbonate particles. Background technique [0002] Calcium carbonate nano- or micron-sized particles or microspheres have extensive and important uses in the fields of coatings, medicine, and pharmacy. Moreover, calcium carbonate can be used as an inorganic material with good tissue compatibility and no side effects, and can be used as an excellent drug slow-release carrier and gene delivery carrier. [0003] Therefore, how to easily prepare nano-calcium carbonate with nanometer size and large loading capacity has become one of the focus issues of research. At present, there are many mature technologies to prepare and produce calcium carbonate powders with different structures and shapes, such as J.F.Chen, Y.H.Wang, F.Guo, X.M.Wang and C.Zheng (Synthesis of Nanoparticles with Novel Te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01F11/18B82Y30/00A61K47/02A61K47/18C12N15/63
CPCC01F11/18A61K47/02A61K47/183B82Y40/00C12N15/64
Inventor 王举孙益民芮定文
Owner ANHUI RUIYAN NEW MATERIAL TECH RES INST
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