Pharmaceutical composition capable of killing drug-resistant aspergillus fumigatus and method for killing drug-resistant aspergillus fumigatus

A technology of drug-resistant Aspergillus fumigatus and composition, applied in the field of microorganisms, can solve problems such as long
CN104474550AInactive Publication Date: 2015-04-01GUANGXI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGXI MEDICAL UNIVERSITY
Publication Date
2015-04-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a pharmaceutical composition capable of killing drug-resistant aspergillus fumigatus and a method for killing drug-resistant aspergillus fumigatus, and belongs to the technical field of microorganism. The pharmaceutical composition is prepared from citral and an antifungal drug, wherein the antifungal drug comprises amphotericin B, voriconazole and itraconazole. The method for killing drug-resistant aspergillus fumigatus comprises the steps of preparing the composition, preparing a spore suspension, determining the drug MIC (Minimal Inhibitory Concentration) and carrying out a united drug sensitivity test. The pharmaceutical composition disclosed by the invention improves the antibacterial effect of the drug to the drug-resistant strain, reduces the toxic or side effects of the antifungal drug and is an ideal pharmaceutical composition for treating antifungal drug resistant aspergillus fumigatus infection.
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Description

technical field

[0001] The invention belongs to the technical field of microorganisms, and in particular relates to a pharmaceutical composition for killing drug-resistant Aspergillus fumigatus and a method for killing drug-resistant Aspergillus fumigatus. Background technique

[0002] With the acceleration of population aging, the sharp increase in patients with malignant tumors, AIDS, organ transplantation, and diabetes has led to the development of a large number of interventional diagnosis and treatment technologies and the use of broad-spectrum antibiotics and glucocorticoids. The current clinically acquired deep fungal infection is developing rapidly. and has become one of the leading causes of death in immunocompromised patients. Invasive pulmonary aspergillosis (IPA) caused by Aspergillus fumigatus is a common and fatal opportunistic infection in immunocompromised patients such as hematological malignancies, organ transplantation, and AIDS, with a mortality rate as h...

Claims

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