Preparation method and application of targeted multi-function double drug-loading liposome

Abstract

The invention belongs to the preparation and application technical field of the liposome and specifically discloses a preparation method and application of targeted multi-function double drug-loading liposome. The raw material for the targeted multi-function double drug-loading liposome comprises the basic film material phospholipid, polyethylene glycol modified phospholipid capable of prolonging the half-life period of the liposome medicine blood, phospholipid capable of having fluorescence imaging, phospholipid having targeted function, lipid-soluble drug and water-soluble drug treating the tumor and contrast agent capable of strengthening nuclear magnetism imaging signal. The medicine can solve the clinic use defect of the medicine with poor water solubility through the package of the phospholipid, the method of administration of the conventional medicine is changed by combining with the water-soluble drug, the targeting action is achieved for the tumor tissue for effectively restraining the tumor growth, reducing the production of the side reaction; the medicine action effect and the tumor change condition can be observed in real time through MRI and great clinical application value is achieved.

Description

Technical field [0001] The invention relates to the technical field of preparation and application of liposomes, and more particularly to a preparation method and application of a targeted multifunctional dual drug-loaded liposome. Background technique [0002] Liposomes composed of phospholipids are similar in composition and structure to biological cell membranes and have good biocompatibility. Liposomes contain a phospholipid bilayer and a hydrophilic core region, which can carry water-soluble and fat-soluble substances, which can improve many deficiencies in drug application. As a drug carrier, liposomes have been successfully used to carry various drugs. Including doxorubicin, cathepsin inhibitors, irinotecan, vinorelbine and osmanthus, diclofenac sodium, etc. [0003] Platinum drugs, including cisplatin, carboplatin, oxaliplatin, etc., can bind to DNA and hinder DNA replication and RNA translation, thereby promoting tumor cell death. It is often used in various cancer trea...

AI Technical Summary

Problems solved by technology

The preparation can cause many side effects, such as allergic reactions, nephrotoxicity and neurotoxicity, etc.

[0005] In clinical practice, paclitaxel and platinum drugs are often used in combination to treat non-small cell lung cancer. Because the preparation itself has no targeting and requires large doses of intravenous injection sequentially, it will cause many side effects at the same time.

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