Phenylethyl resorcinol lipid nanoparticle as well as preparation method and use thereof

A technology of phenylethylresorcinol lipid and phenylethylresorcinol, which is applied in the field of phenethylresorcinol lipid nanoparticles and its preparation, can solve the problem of the stability of phenylethylresorcinol In order to avoid problems such as poor performance, the preparation method is simple and controllable, the stability is high, and the moisturizing effect is increased.

Active Publication Date: 2015-04-22
苏州纳康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the above-mentioned technical problems, the present invention provides a kind of phenylethylresorcinol lipid nanoparticle and its preparation method and application, and its purpose is to pr

Method used

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  • Phenylethyl resorcinol lipid nanoparticle as well as preparation method and use thereof
  • Phenylethyl resorcinol lipid nanoparticle as well as preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh 12g caprylic / capric triglyceride, 5g acetylated monoglyceride, 3g butyl octanyl salicylate, 5g laureth-23, 10g steareth-21, 5g PEG-30 dimer Hydroxystearate, 5g PEG-40 Stearate, 1g Steareth-2,3g 1,3-Butanediol, 1g Diethylhexylsyrylidenemalonate and Caprylic / Capric Triglycerides Esters, 0.1g disodium EDTA, stirred at 65°C to form a transparent solution, added 4g of phenylethylresorcinol, the stirring speed was 300rpm, and the stirring time was 6min, added 45.9g of deionized water in the same temperature water bath, 300rpm / min stirred for 8 min, and then cooled to obtain light yellow translucent phenylethylresorcinol lipid nanoparticle solids. The particle size of the phenylethylresorcinol lipid nanoparticle solids was measured by a laser particle size analyzer to be about 334nm.

Embodiment 2

[0026] Weigh 5g glyceryl monostearate, 10g butyl octanol salicylate, 5g caprylic / capric triglyceride, 5g sorbitan olivate, 5g polysorbate-80, 5g PEG-30 dimer Hydroxystearate, 3g C14-22 Alcohol and C12-20 Alkyl Glucoside, 5g Laureth-23, 5g PEG-40 Stearate, 4g Ethoxydiethylene Glycol, 3g 1,3-Butanediol, 1g of hydroxytoluene, 0.1g of disodium EDTA, stirred at 70°C to form a transparent solution, added 3g of phenylethylresorcinol, the stirring speed was 400rpm, and the stirring time was 6min, and 40.9g of deionized water in the same temperature water bath was added. 300rpm / min stirs 8min, after cooling obtains light yellow translucent phenylethyl resorcinol lipid nanoparticle solid, and this phenylethylresorcinol lipid nanoparticle solid measures its particle diameter by laser particle size analyzer and is about 225nm.

Embodiment 3

[0028] Weigh 12.5g caprylic / capric triglyceride, 2.5g glyceryl monostearate, 3g acetylated monoglyceride, 5g vitamin E acetate, 8g steareth-21, 5g PEG-30 dipolyhydroxyhard Fatty acid esters, 2g Sorbitan Olivate, 3g Polysorbate-80, 3g Ceteth-25, 4g PEG-8 Caprylic / Capric Glycerides, 5g PEG-40 Stearate, 3g Coco Glucoside / Coco Alcohol, 3g 1,3-Butanediol, 2g Ceteth-6, 2g Steareth-2, 1g Tetrahydrocurcumin, stirred at 75°C to form Transparent solution, add 5g of phenylethylresorcinol, stirring speed is 350rpm, stirring time is 5min, add 31g of deionized water in the same temperature water bath, stir for 7min at 350rpm / min, after cooling to obtain light yellow translucent phenylethylresorcinol Resorcinol lipid nanoparticle solid, the particle size of the phenylethyl resorcinol lipid nanoparticle solid is about 65nm as measured by a laser particle size analyzer.

[0029] A kind of phenylethylresorcinol lipid nanoparticle provided by the present invention and its preparation method and...

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Abstract

The invention provides a phenylethyl resorcinol lipid nanoparticle as well as a preparation method and use thereof. The phenylethyl resorcinol lipid nanoparticle is composed of an active component phenylethyl resorcinol, lipid, an emulsifier, a co-emulsifier and a stabilizer; the phenylethyl resorcinol lipid nanoparticle is faint yellow and semi-transparent and has high light stability; the phenylethyl resorcinol lipid nanoparticle is transparent and blueing after being dispersed by hot water; the colour of the phenylethyl resorcinol lipid nanoparticle still cannot be changed after being illuminated for a month; the phenylethyl resorcinol lipid nanoparticle can be freely matched with cosmetic formulae; the preparation method of the phenylethyl resorcinol lipid nanoparticle is simple, controllable and good in repeatability; and in addition, after being applied to cosmetic formulae, the phenylethyl resorcinol lipid nanoparticle has the effects of whitening skin, improving skin touch and moisturizing.

Description

technical field [0001] The invention relates to the technical field of carrier systems in cosmetic preparation technology, and more specifically relates to phenethyl resorcinol lipid nanoparticles and its preparation method and application. Background technique [0002] The full name of phenylethyl resorcinol is 4-(1-phenylethyl)-1,3-resorcinol, which is a white crystalline solid with the molecular formula C 14 h 14 o 2 , molecular weight: 214.27g / mol, melting point: 78-82°C. Phenylethyl resorcinol has an excellent skin whitening effect, and its main function is to inhibit the rate-limiting enzyme tyrosinase, which is one of the most active tyrosinase inhibitors reported. In the analysis experiment of B16V melanocytes, phenylethyl resorcinol is the most effective in inhibiting melanin synthesis among all test compounds, and its IC 50 The value (50% inhibitory concentration) was 2uM; the MTT test carried out in B16V cells confirmed that the whitening effect of phenylethyl...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/34A61Q19/02A61Q19/00
Inventor 夏强
Owner 苏州纳康生物科技有限公司
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