New method for preparing thiabendazole

Abstract

The invention relates to a new method for synthesizing thiabendazole. Acetone and chlorine are taken as starting materials to synthesize chloroacetone, chloroacetone not subjected to separation can directly react with thiocarbamide to obtain 2-Amino-4-methylthiazole which is subjected to diazotization to obtain 4-methylthiazole, and 4-methylthiazole is oxidized to produce 4-thiazolecarboxylic acid, and finally, 4-thiazolecarboxylic acid reacts with o-phenylenediamine to obtain the target object thiabendazole. The thiabendazole is a broad-spectrum anthelmintic, can repel roundworms, hookworms, whipworms, pinworms, strongyloises stercoralis and trichinization, is also a broad-spectrum efficient disinfectant and is widely used as a fruit fresh-keeping agent and a bactericidal mildew inhibitor in various fields over the past decade in China.

Description

technical field

[0001] The invention relates to a drug synthesis method, in particular to a new synthesis method of a compound with the common name Thiabendazole, and belongs to the field of chemical synthesis. Background technique

[0002] Thiabendazole, also known as Thiabendazole and Tibendazole, or TBZ for short, is an excellent anti-mold preservative. It is mainly used for fruit and vegetable preservation, food antisepsis and daily necessities such as grain, cloth, decorative materials, etc. It has the characteristics of high efficiency, broad spectrum, low toxicity, and less residue, so it has been approved in the food additive standards of various countries in the world. Anti-mold and preservation of fruits and vegetables.

[0003] Have a lot of document patents to also publicly report the synthetic method of thiabendazole at present, as shown in following synthetic route: use lactic acid and o-phenylenediamine as starting raw material, first generate 2-hydroxyethylb...

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