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Preparation method of moisture-proof traditional Chinese medicine coated film

A film coating, traditional Chinese medicine technology, applied in pharmaceutical formulations, drug delivery, oil/fat/wax inactive ingredients, etc., can solve the problems of high energy consumption, serious environmental pollution, flying dust, etc., to improve drug quality, chemical Stable properties and the effect of improving stability

Inactive Publication Date: 2015-05-06
刘桐言
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coating process of the sugar coating layer takes a long time, consumes a lot of energy, dust is flying, the environment is polluted seriously, the labor intensity is high and the operation is mostly based on experience, which affects the quality of the tablet and the health of the workers
The main raw materials of sugar-coated tablets are simple syrup and talcum powder. The sugar-coated layer itself is unstable, has poor moisture resistance, heat resistance, and cold resistance, and is easy to change color. Improper storage is prone to fission
In addition, the amount of talcum powder in the sugar-coated tablet accounts for 35% of the weight of the tablet core, and the micropowdered silica gel is cold in nature and contains traces of asbestos. After taking it, it will cause potential harm to the health of the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Take 32g of hydroxypropylmethylcellulose, 6g of triethyl citrate, 8g of xylitol, 7ml of castor oil, 805ml of Tween, 14g of dextrin, 6g of micronized silica gel, 10g of corn protein, and 1% food coloring solution Add 8ml, 360ml of distilled water at 42±1°C, and 95% ethanol to 1000ml.

[0017] 2. Production process (dosage as 1):

[0018] ①Use distilled water at 42±1°C to dissolve hydroxypropylmethylcellulose and triethyl citrate with ethanol for later use, and add castor oil and Tween-80 to the ethanol solution of triethyl citrate for later use;

[0019] ②After mixing the liquid described in step 1 evenly, add dextrin, micronized silica gel and corn gluten through an 80-mesh sieve in turn, then add food coloring solution, stir evenly, pass through the colloid mill for 5 times and set aside;

[0020] ③Sieve out the fine powder, fragments and debris in the tablet, put the tablet in the coating pan and preheat it to 48±2°C, spray the coating material on the tablet, and ...

Embodiment 2

[0024] 1. The film coating formula is: 38g of hypromellose, 7g of triethyl citrate, 6g of xylitol, 5ml of castor oil, 807ml of Tween, 17g of dextrin, 8g of micronized silica gel, 7g of corn protein, Add 6ml of 1% food coloring solution, 400ml of distilled water (47±1°C), and 95% ethanol to 1000ml.

[0025] 2. The coating process is the same as in Example 1.

Embodiment 3

[0027] 1. The film coating formula is: 38g of hypromellose, 7g of triethyl citrate, 6g of xylitol, 5ml of castor oil, 807ml of Tween, 17g of dextrin, 8g of micronized silica gel, 7g of corn protein, Add 6ml of 1% food coloring solution, 400ml of distilled water (47±1°C), and 95% ethanol to 1000ml.

[0028] 2. The coating process is the same as in Example 1.

[0029] The Ganmaoqing tablet made by the process of the present invention and the Ganmaoqing tablet made by the sugar-coating process are sampled and tested, and the appearance results are as follows:

[0030] Sugar-coated tablets: uneven surface, uniform color, bright and bright.

[0031] Film-coated tablets: complete shape, firm coating, consistent thickness, uniform color, good finish, but the color is slightly duller than sugar-coated tablets. Sugar-coated tablets will fade, burst, dissolve, and disintegrate for more than 60 minutes under direct infrared radiation at 70-80°C and -5°C.

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Abstract

The invention discloses a preparation method of a moisture-proof traditional Chinese medicine coated film, which relates to a coating technology of the traditional Chinese medicine and belongs to the medicinal preparation field. The moisture-proof traditional Chinese medicine coated film comprises the following components: 30-40 parts of hydroxypropyl methyl cellulose, 5-8 parts of triethyl citrate, 6-10 parts of xylitol, 4-8 parts of castor oil, 4-8 parts of tween-80, 14-18 parts of dextrin, 6-10 parts of aerosol, 6-10 parts of zein, 5-10 parts of 1% of artificial food coloring solution, 350-420 parts of distilled water (40-50 DEG C) and balance of ethanol with 95% of concentration; wherein weight unit of solid is gram, and volume unit of liquid is milliliter. The moisture-proof traditional Chinese medicine coated film has the beneficial effect of stable chemical property of a film forming substance, inertia to an enzyme system, no physiological toxicity and no usage of cane sugar; the coated film has the advantages of moisture resistance, heat resistance, cold resistance and abrasion resistance which are better than that of the sugar coated tablets, so that the stability of the coated film is increased, and storage period is prolonged.

Description

technical field [0001] The invention relates to a coating process of traditional Chinese medicine, which belongs to the field of pharmaceutical preparations, in particular to a method for preparing moisture-proof film coating of traditional Chinese medicine. Background technique [0002] The chemical composition contained in traditional Chinese medicine is complex, whether it is biologically active ingredients such as alkaloids, glycosides, volatile oils, amino acids, etc., or non-biologically active ingredients such as sugars, proteins, pigments, resins, inorganic salts, etc., most of them have strong hygroscopicity. sex. Due to the strong moisture-absorbing, volatile, or ingredients that can cause taste and smell discomfort in the contained plants, sugar-coating layers were generally used to isolate the exchange of substances inside and outside the tablet. Some patients are not suitable to take too much sugar-coated tablets, and sugar-coated tablets are prone to moisture ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/44A61K9/38
Inventor 刘桐言
Owner 刘桐言
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