Medicine composition for assisting chemotherapeutics and application of medicine composition

A technology of pharmaceutical composition and chemotherapeutic drugs, applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical preparations containing active ingredients, etc., which can solve problems such as hematopoiesis, patient immunity, and hematopoietic system damage

Active Publication Date: 2015-05-13
BALAY BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chemotherapy can successfully kill cancer cells, it will not selectively kill normal cells at the same time, usually causing serious damage to the patient's immune and hematopoietic systems, resulting in the "death" of good cells and bad cells. Chemotherapy also affects the normal cells that generally prol

Method used

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  • Medicine composition for assisting chemotherapeutics and application of medicine composition
  • Medicine composition for assisting chemotherapeutics and application of medicine composition
  • Medicine composition for assisting chemotherapeutics and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Preparation method and HPLC analysis of Antrodia antrodia fruiting body extract

[0057] 1. The fruiting body of Antrodia camphorata used in the present invention complies with the specifications and standards of the CNS15654 draft, and the diameter of the mushroom body is about 13 cm. The surface can be clearly distinguished with the unique porous characteristics of the fruiting body of Antrodia camphorata with a dissecting microscope, and the dry weight of a single piece of mushroom body is About 6-15 grams.

[0058] 2. Preparation of Antrodia Antrodia Fruiting Body Extract

[0059] Please refer to figure 1 , illustrating the extraction and separation process of Antrodia antrodia fruiting body extract, the steps include: first, as in step S10, take the dry powder of Antrodia antrodia fruiting body, as in step S20, the first extraction process is 30 times the volume of 80-100 ℃ hot water Soak for 1 to 3 hours, as in step S30, use No. 1 filter paper ( #1)...

Embodiment 2

[0066] Embodiment 2: Antrodia camphorata fruiting body extract of the present invention adjuvant chemotherapy drugs (cisplatin and Gemza) to improve the animal experiment of lung cancer treatment effect

[0067] This experiment adopts LLC (Lewis Lung Carcinoma) / C57BL / 6 lung cancer animal model, and the animal used in the experiment is male C57BL / 6mice 8 weeks old, with a body weight of about 25 grams. The breeding environment provides a 12-hour light cycle (AM 7:00-PM 7:00), with proper temperature and humidity control, and sufficient supply of feed and drinking water. The cancer cell line used is mouse lung cancer cell LLC, cultured in Dulbecco's Modified eagle medium (DMEM medium) environment containing 10% heat-inactivated fetal bovine serium (FBS), 100unit / mL Penicillin-Streptomycin (P / S) . The LLC cells were harvested using 0.05% Trypsin-EDTA. Use FBS to dilute and adjust the cell concentration to 2×107 cells / mL, inject 0.1 mL of the adjusted cell concentration into the...

Embodiment 3

[0079] Example 3: Antrodia Antrodia fruiting body extract improves the effect of chemotherapy drugs (cisplatin and Gemza) on hair loss

[0080] The test method is the same as that in Example 2. The test mice terminated the experiment after three weeks of continuous administration, and the hair loss of the test mice in each group was observed and photographed. The test results showed that the CGC group was significantly more hair loss than the Normal group. In addition, the CGC group Hair loss is serious, and the CGCA group fed with Antrodia camphorata fruiting body extract can significantly improve the hair loss of the CGC group.

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Abstract

The invention discloses a medicine composition for assisting chemotherapeutics and an application of the medicine composition. An effective dose of antrodia camphorata sporocarp extract is obtained by hot water soaking, low polar solvent extraction and other steps and collocated with a pharmaceutically acceptable supporting agent to prepare the medicine composition; the medicine composition can be used for improving a treatment effect of the chemotherapeutics cisplatin and gemcitabine on a cancer; and at the same time, the medicine composition can improve side effects such as hair slipping, muscle degradation and atrophy, gastrointestinal injury and kidney inflammation injury in a process of treating the cancer.

Description

technical field [0001] The present invention relates to antrodia camphorata extract and its application, in particular to a pharmaceutical composition for adjuvant chemotherapy drugs and its application. Background technique [0002] Antrodia cinnamomea (or Antrodia cinnamomea) is a unique species of mushroom in Taiwan. It only grows on the camphor trees unique to Taiwan's middle and high altitude (400-2000 meters) mountainous areas. It is known by the aborigines to protect the liver and relieve alcohol. Use of precious mushrooms. Research results since 1995 have shown that the fruiting bodies of Antrodia Antrodia have various functions such as anti-inflammation, enhancing immunity and physical strength, anti-virus, anti-oxidation, anti-cancer and liver protection, and many documents directly use animal models (in vivo) Carry out anti-cancer research, including liver cancer, lung cancer, colorectal cancer and ovarian cancer, etc. It has been confirmed that the ethanol extra...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61K31/575A61K31/36A61P35/00A61P17/14A61P21/00A61P1/00A61P13/12
Inventor 翁丰岳刘文煌郭建良林佳祺
Owner BALAY BIOTECH
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