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Preparation method for multi-amino-acid polymer/strontium-containing calcium sulfate composite material

A composite material, calcium sulfate technology, applied in medical science, prosthesis, etc., can solve the problem that it is difficult to meet the comprehensive requirements of biological activity and biomechanical properties, and achieve the effect of simple preparation process

Inactive Publication Date: 2015-05-13
贺灿辉
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, calcium sulfate degrades too fast, often completely degraded before new bone is formed, and a single inorganic material or a single organic material is difficult to meet the clinical comprehensive requirements for the bioactivity and biomechanical properties of bone repair materials

Method used

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specific Embodiment

[0008] Specific embodiment: The preparation process of the present invention is: mixing calcium sulfate (CS) and strontium nitrate according to Sr / (Ca+Sr) of 0.1% (mole fraction), stirring them evenly, and then washing with deionized water and drying Obtain strontium-doped calcium sulfate powder; add 6g alanine, 7g phenylalanine, 108g 6-aminocaproic acid, 6g proline, 12.5g gamma-aminobutyric acid, 2g lysine to the stirring and gas protection device Into the reaction flask, inject deionized water, turn on the stirring to dissolve and mix the various amino acids uniformly. The reaction flask is filled with nitrogen protection, and the reaction system is heated to 200°C. After dehydration is completed, the reaction system is heated to 220°C and 187g is added Doped with strontium calcium sulfate, dehydrated for 2h, then heated to 230°C and continued to react for 2h, after the reaction, continue to pass nitrogen until the system is cooled to room temperature, to obtain a strontium-do...

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Abstract

A preparation method for a multi-amino-acid polymer / strontium-containing calcium sulfate composite material belongs to the field of preparation of artificial bone-defect restoration materials. The preparation method aims at the problems that conventional calcium sulfate is too fast in degradation speed and is completely degraded before new bone is formed, and prepares the multi-amino-acid polymer / strontium-containing calcium sulfate composite material which has good biocompatibility and bone conductivity. The preparation method comprises employing alanine, phenylalanine, 6-aminocaproic acid, proline, gamma-aminobutyric acid, lysine and other multiple amino acids as raw materials, and performing in-situ combination with strontium-doped calcium sulfate, so as to prepare the multi-amino-acid polymer / strontium-containing calcium sulfate composite material. The multi-amino-acid polymer / strontium-containing calcium sulfate composite material prepared by the preparation method combines good mechanical properties of the amino acid polymer and good biocompatibility and bone conductivity of strontium-doped calcium sulfate, and has wide application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of materials for artificially repairing bone defects. Background technique [0002] In recent years, with the development of tissue engineering, the development of ideal artificial biomaterials to repair bone defects has become an important topic in the field of orthopedics and biomaterial science. Calcium sulfate (CS) has been used as a bone defect filling and repairing material for hundreds of years. Calcium sulfate has good biocompatibility, does not cause immune response, does not produce inflammatory response and foreign body stimulation to surrounding tissues, and can promote bone regeneration. However, the degradation rate of calcium sulfate is too fast, and it is often completely degraded before new bone is formed, and it is difficult for a single inorganic material or a single organic material to meet the clinical comprehensive requirements for the bioactivity and biomechanical properties of b...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/50
Inventor 贺灿辉
Owner 贺灿辉