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A kind of injectable water-absorbing swelling bone cement and preparation method thereof

A water-swelling, bone cement technology, used in medical science, surgery, surgical adhesives, etc., can solve the problems of joint wear, high elastic modulus, high strength, etc., to reduce the elastic modulus, improve the strength, and improve the bonding strength. Effect

Inactive Publication Date: 2017-07-28
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide an injectable water-absorbing swelling bone cement, which solves the problem that the existing PMMA bone cement causes different degrees of wear and tear on the joints in the human body due to volume shrinkage, excessive strength, and high elastic modulus.

Method used

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  • A kind of injectable water-absorbing swelling bone cement and preparation method thereof
  • A kind of injectable water-absorbing swelling bone cement and preparation method thereof

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preparation example Construction

[0037] The preparation of the water-absorbing resin can also adopt the reverse phase suspension polymerization method or the reverse phase emulsion polymerization method.

[0038] According to requirements, the water-absorbent resin fiber can be cut to an aspect ratio of 0.5-3:1.

[0039] Step 2, preparation of injectable bone cement precursor:

[0040] Prepare methyl methacrylate-styrene copolymer by suspension polymerization method, specifically: measure methyl methacrylate and styrene at a volume ratio of 7:2-4, and use the mass-volume ratio of dispersant to methyl methacrylate Weigh the dispersant at 0.012g / 7ml, weigh the initiator according to the mass volume ratio of the initiator and methyl methacrylate to be 0.25g / 7ml, add the dispersant and initiator to the mixed solution of methyl methacrylate and styrene in sequence , react at 80°C for 2h, and dry at 80°C to obtain methyl methacrylate-styrene copolymer, wherein the dispersant is composed of polyvinyl alcohol, sodiu...

Embodiment 1

[0047] Step 1, preparing water-absorbent resin fibers:

[0048] Weigh 5.75g of sodium hydroxide, dissolve it in 25ml of distilled water, stir evenly, add 10ml of acrylic acid dropwise, react for 10min, add 0.9g of N-N methylenebisacrylamide, and wait until the N-N methylenebisacrylamide is completely dissolved , the solution was lowered to room temperature, and then 0.1 g of potassium persulfate was added, and after stirring for 3 minutes, the mixed solution was injected into a mold with a cylindrical cavity and an inner diameter of 1.0 mm with a syringe. Put it in a water bath, and after 30 minutes, when the temperature reaches 72°C, a gel-like water-absorbing resin is obtained. Dry in an oven at 70°C for 5 hours, cut the water-absorbent resin fibers into short fibers with a length of 2.0 mm, and obtain water-absorbent resin fibers with an inner diameter of 1.0 mm and an aspect ratio of 2:1.

[0049] Step 2, preparation of injectable bone cement precursor:

[0050] Measure ...

Embodiment 2

[0055] Step 1, preparing water-absorbent resin fibers:

[0056] Weigh 5.75g of sodium hydroxide, dissolve it in 20ml of distilled water, stir evenly, add 10ml of acrylic acid dropwise, react for 10min, add 0.9g of N-N methylenebisacrylamide, and wait until the N-N methylenebisacrylamide is completely dissolved , the solution was lowered to room temperature, and then 0.1 g of potassium persulfate was added, and after stirring for 3 minutes, the mixed solution was injected into a mold with a cylindrical cavity and an inner diameter of 0.5 mm with a syringe. Put it in a water bath, and after 40 minutes, when the temperature reaches 65°C, a gel-like water-absorbing resin is obtained. Dry in an oven at 65°C for 5.5 hours, cut the water-absorbent resin fibers into short fibers with a length of 0.5 mm, and obtain water-absorbent resin fibers with an inner diameter of 0.5 mm and an aspect ratio of 1:1.

[0057] Step 2, preparation of injectable bone cement precursor:

[0058] Measur...

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Abstract

The invention discloses an injectable water-absorbing and swelling bone cement, which comprises the following raw materials in percentage by weight: 0.002%-0.09% of methyl methacrylate monomers, 0.001%-0.0018% of N,N-Dimethyl-p-toluidine, 0.0015%-0.0045% of hydroquinone, 0.705%-66.6023% of methyl methacrylate-styrene copolymer, 0.12%-14.4014% of polymethyl methacrylate, 0.05%-9% of barium sulfate, 9.9%-90.1205% of water-absorbing resin fibers. The invention further provides a preparation method of the bone cement, and the preparation method specifically comprises the following step: mixing the prepared water-absorbing resin fibers with the injectable bone cement precursor to obtain injectable water-absorbing and swelling bone cement. The water-absorbing resin fibers in the injectable water-absorbing and swelling bone cement are increased in volume after absorbing water, the elastic modulus of the bone cement can be reduced, the volume contraction of PMMA bone cement in self polymerization can be offset, and the bone and prosthesis are firmly bonded.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical biological materials, and relates to an injectable water-absorbing swelling bone cement, and also relates to a preparation method of the bone cement. Background technique [0002] Bone cement is a biomaterial used to fill the gap between bone and implant or bone cavity and has self-setting properties. Because of its physical properties and its appearance and properties after solidification, it is quite similar to white cement for building decoration. so named. Bone cement has been widely used in clinical orthopedics since the first application of bone cement to fix the femoral prosthesis in the 1960s for the successful implementation of total hip replacement. Bone cement fixation can ensure the immediate stability of the prosthesis after surgery. There is no micromotion on the body interface, allowing early postoperative weight bearing. At present, bone cement is widely used in fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/04A61L24/00
Inventor 赵康陈磊汤玉斐吴子祥雷伟
Owner XIAN UNIV OF TECH
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