Preparation method of nifedipine tablet
A technology for nifedipine and dipine tablets, applied in the field of nifedipine tablets, can solve the problem that the particle size of nifedipine raw materials is not easy to control, and achieve the effects of improving the dissolution rate and ensuring product quality
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[0015] Example 1
[0016] Per 10,000 pieces prepared
[0017] (1) The raw material nifedipine is ultra-finely pulverized with a jet mill to a particle size D50 of less than 1μm; other raw materials, magnesium stearate, microcrystalline cellulose, carboxymethyl starch and compressible starch, are processed by a universal high-speed pulverizer After crushing, use a vortex vibrating sieve to pass through a 120-mesh sieve; weigh the sieved raw and auxiliary materials, and take 500g of the raw and auxiliary materials nifedipine; take 20g of magnesium stearate, 200g of microcrystalline cellulose, and 750g of compressible starch. 570g of carboxymethyl starch is reserved.
[0018] (2) Preparation of adhesive: (per ten thousand pieces): 400ml of 1-3% hydroxypropyl methylcellulose 30% ethanol solution, 25ml of polysorbate-80, and 10g of sodium lauryl sulfate for adhesive Agent
[0019] (3) Transfer 500 g of nifedipine to the fluidized bed, and set the fan frequency to make the material in a g...
Example Embodiment
[0024] Example 2
[0025] Per 10,000 pieces prepared
[0026] (1) The raw material nifedipine is ultra-finely pulverized with a jet mill to a particle size D50 of less than 10μm; other raw materials, magnesium stearate, microcrystalline cellulose, carboxymethyl starch and compressible starch, are used in a universal high-speed pulverizer After crushing, use a vortex oscillating sieve to pass through a 120-mesh sieve; weigh the sieved raw and auxiliary materials, take 500g of the raw and auxiliary materials, nifedipine, and use a jet mill for ultrafine pulverization to a particle size of less than 1-10μm; take hard 20g magnesium fatty acid, 166.6g microcrystalline cellulose, 625.05g compressible starch, 528.35g carboxymethyl starch, spare;
[0027] (2) Preparation of adhesive: (per ten thousand pieces): 800ml of 1-3% hydroxypropyl methylcellulose 30% ethanol solution, add 45ml of polysorbate-80, add 30g of sodium lauryl sulfate for adhesive Agent
[0028] (3) Transfer 500 g of nifedi...
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