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Preparation of molecular imprinting release controlled drug carrier through taking metal and organic gel as pore-foaming agent

An organogel and molecular imprinting technology, which is applied in the field of -BTC) metals, can solve the problems of inability to specifically recognize template molecules and holes without template molecule configurations, and achieve easy operation, simple preparation process, and obvious imprinting effect Effect

Active Publication Date: 2015-06-10
嘉兴慧泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No-imprinting polymers (NIP) that do not add template molecules during synthesis do not have template molecule configuration holes and cannot specifically recognize template molecules

Method used

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  • Preparation of molecular imprinting release controlled drug carrier through taking metal and organic gel as pore-foaming agent
  • Preparation of molecular imprinting release controlled drug carrier through taking metal and organic gel as pore-foaming agent
  • Preparation of molecular imprinting release controlled drug carrier through taking metal and organic gel as pore-foaming agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] To confirm that Fe 3+ -The role of BTC metal-organic gels in the synthesis of levofloxacin molecularly imprinted polymers. We prepared two levofloxacin molecularly imprinted polymers, one based on Fe 3+ - BTC metal-organic gel as porogen levofloxacin molecularly imprinted polymer, the other is Fe-free 3+ -BTC metal-organic gel was used as porogen levofloxacin molecularly imprinted polymer, and scanning electron microscope analysis was carried out on the two polymers to characterize the morphological characteristics and nitrogen adsorption analysis of the particles. The specific operation steps were as follows:

[0026] with Fe 3+ -BTC metal-organic gel is the porogen levofloxacin molecularly imprinted polymer preparation method:

[0027] a. template molecule levofloxacin 0.99% (both mass percent), functional monomer methacrylic acid 1.88%, initiator azobisisobutyronitrile 0.16%, crosslinking agent ethylene glycol dimethacrylate 17.41 %, gel ligand trimesic acid 1.83 ...

Embodiment 2

[0037] Experimental study on equilibrium adsorption of levofloxacin with Fe 3+ -Specific adsorption performance of levofloxacin molecularly imprinted polymer with BTC metal-organic gel as porogen to imprinted molecule levofloxacin, in order to investigate the specificity of imprinted polymer to levofloxacin To determine the recognition ability, the adsorption isotherms of levofloxacin-imprinted polymers and non-imprinted polymers in the range of 0-10 mmol / L were determined. The specific operation steps are as follows:

[0038] a. Synthesize with the above-mentioned method (embodiment 1) with Fe 3+ -BTC metal-organic gel is the levofloxacin molecularly imprinted polymer MIP of porogen, and the synthesis of non-imprinted polymer NIP is the same as levofloxacin except that the template molecule levofloxacin is not added. Synthesis of Molecularly Imprinted Polymers.

[0039] b. Weigh 20.0 mg of dry levofloxacin molecularly imprinted polymer and non-imprinted polymer respectivel...

Embodiment 3

[0046] Drug Release Experiments A model for studying the kinetics of drug release from levofloxacin molecularly imprinted polymers. In order to investigate the drug release model, the total amount of drug released by levofloxacin molecularly imprinted polymers and non-imprinted polymers within a certain period of time was determined. The specific operation steps are as follows:

[0047] a. Synthesize with the above-mentioned method (embodiment 1) with Fe 3+ -BTC metal-organic gel is the levofloxacin imprinted polymer MIP of the porogen, and the synthesis of the non-imprinted polymer NIP is the same as the levofloxacin molecule except that the template molecule levofloxacin is not added. Synthesis of imprinted polymers.

[0048] b. Soak the synthesized levofloxacin molecularly imprinted polymer and non-imprinted polymer in pH 7.40 phosphate buffer solution of levofloxacin, then wash twice with double distilled water, and dry at room temperature; Weigh the drug-loaded levoflo...

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Abstract

The invention relates to preparation of a molecular imprinting release controlled drug carrier through taking metal and organic gel as a pore-foaming agent, in particular to a levofloxacin release controlled molecular imprinting polymer material which takes ferric iron and trimesic acid (Fe<3+>-BTC) metal and organic gel as the pore-foaming agent and a preparation method thereof. The raw materials comprise, by mass, 0.66-1.3% of levofloxacin, 18-27% of ethyldiol methacrylate, 1.7-2.5% of methacrylic acid, 0.14-0.16% of azodiisobutyronitrile, 4.8-5.5% of ferric nitrate, 1.6-1.9% of the trimesic acid and 63-73% of absolute ethyl alcohol, wherein the mass ratio of the ferric nitrate to the trimesic acid is three to one. According to the preparation of the molecular imprinting release controlled drug carrier through taking metal and organic gel as the pore-foaming agent, the slow-release controlling effect of the MIP carrier is good, compared with the release time (5 h) of a non-imprinting polymer-drug, the MIP carrier can release the levofloxacin for more than 16 h, the physical and chemical properties are stable, and therefore a foundation is laid for the molecular imprinting technique to be applied to a drug delivery system.

Description

technical field [0001] The invention relates to a molecularly imprinted controlled-release drug carrier with a metal-organic gel as a porogen and a preparation method thereof. Specifically, ferric-trimesic acid (Fe 3+ -BTC) Levofloxacin controlled-release molecularly imprinted polymer material with metal-organic gel as porogen. The polymer has a large specific surface area and specific adsorption performance, and the drug release time can reach 18 h. The release model is a zero-order release model. Background technique [0002] Molecular imprinting technique (MIT), also known as molecular imprinting technique, is a technique developed on the basis of simulating the interaction of enzyme-substrate and receptor-antibody in nature to synthesize a preselective stationary phase. Molecular imprinting polymers (Molecular imprinting polymers, MIP) use molecular imprinting technology to synthesize a polymer with specific recognition properties. The basic principle is to dissolve the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/26A61K47/32
Inventor 黄艳萍马丽刘照胜
Owner 嘉兴慧泉生物科技有限公司
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